Hadzic's Peripheral Nerve Blocks and Anatomy for Ultrasound-Guided Regional Anesthesia, 2nd

12. Interscalene Brachial Plexus Block


FIGURE 12-1. Needle insertion for interscalene brachial plexus block. The needle is inserted between palpating fingers that are positioned in the scalene groove (between anterior and middle scalene muscles). 1 = sternal head of the sternocleidomastoid muscle. 2 = clavicular head of the sternocleidomastoid muscle.

General Considerations

An interscalene block relies on the spread of a relatively large volume of local anesthetic within the interscalene groove to accomplish blockade of the brachial plexus. In our practice, we almost always use a low interscalene block technique, which consists of inserting the needle more caudally than in the commonly described procedure performed at the level of the cricoid cartilage. Our reasoning is that at the lower neck, the interscalene groove is more shallow and easier to identify, and the distribution of anesthesia is also adequate for elbow and forearm surgery. In addition, the needle insertion is more lateral, which makes puncture of the carotid artery less likely and performance of the block easier to master by trainees. Low approach to interscalene block is used in shoulder, arm, and forearm surgery. In our practice, the most common indications for this procedure are shoulder and humerus surgery and the insertion of an arteriovenous graft for hemodialysis.

Functional Anatomy

The brachial plexus supplies innervation to the upper limb and consists of a branching network of nerves derived from the anterior rami of the lower four cervical and the first thoracic spinal nerves. Starting from their origin and descending distally, the components of the plexus are named roots, trunks, divisions, cords, and, finally, terminal branches. The five roots of the cervical and the first thoracic spinal nerves (anterior rami) give rise to three trunks (superior, middle, and inferior) that emerge between the medial and anterior scalene muscles to lie on the floor of the posterior triangle of the neck (Figure 12-2). The roots of the plexus lie deep to the prevertebral fascia, whereas the trunks are covered by its lateral extension, the axillary sheath. Each trunk divides into an anterior and a posterior division behind the clavicle, at the apex of the axilla (Figure 12-3). The divisions combine to produce the three cords, which are named lateral, median, and posterior according to their relationship to the axillary artery. From this point on, individual nerves are formed as these neuronal elements descend distally (Figure 12-3 and Table 12-1).


FIGURE 12-2. Anatomy of the brachial plexus. The sternocleidomastoid muscle is removed and the brachial plexus Image is seen emerging between the scalene muscles. Image internal jugular vein. Image carotid artery. Image subclavian artery. Image Retracted pectoralis muscle. Image medial and lateral pectoral nerves. The number “1” also indicates the approximate level at which the block is performed where the roots of the muscles are emerging between the scalene muscles.


FIGURE 12-3. Functional organization of the brachial plexus and formation of the terminal nerves.


TABLE 12-1 Distribution of the Brachial Plexus

Distribution of Blockade

The interscalene approach to brachial plexus blockade results in anesthesia of the shoulder, arm, and elbow (Figure 12-4). Note that the skin over and medial to the acromion is supplied by the supraclavicular nerve, which is a branch of the cervical plexus. Supraclavicular nerves are usually blocked with the brachial plexus when an interscalene block is performed. This is because the local anesthetic invariably spills over from the interscalene space into the prevertebral fascia and blocks the branches of the cervical plexus. The classic interscalene block is not recommended for hand surgery due to potential sparing of the inferior trunk and the lack of blockade of the C8 and T1 roots.


FIGURE 12-4. Sensory distribution of the brachial plexus. The innervation is shown for didactic purposes; the exact extent of anesthesia with interscalane block varies considerably and often spares the hand.

Single-Injection Interscalene Block


A standard regional anesthesia tray is prepared with the following equipment:

• Sterile towels and gauze packs

• 2 × 20-mL syringes containing local anesthetic

• A 3-mL syringe and 25-gauge needle with local anesthetic for skin infiltration

• A 3.5-cm, 22-gauge, short-bevel insulated stimulating needle

• Peripheral nerve stimulator

• Sterile gloves; marking pen

Landmarks and Patient Positioning

The patient is in a supine or semi-sitting position with the head facing away from the side to be blocked (Figure 12-5). The arm should rest comfortably on the bed, abdomen, or arm-board to allow detection of responses to nerve stimulation. Removal of a cast (when present) can help to detect motor response, although removal is not essential because the responses to nerve stimulation are usually mixed (stimulation of trunks and divisions rather than specific nerves) and proximal motor response is adequate (e.g., deltoid, pectoralis).


FIGURE 12-5. Landmarks for the interscalene brachial plexus. White arrows: clavicle. Red arrows: posterior border of the sternocleidomastoid muscle. Blue arrow: external jugular vein. The palpating fingers are positioned lateral and posterior to the clavicular head of the sternocleidomastoid muscle in the space between anterior and middle scalene muscles. The scalene groove is often palpated just in front or behind the external jugular vein.

These are the primary landmarks for performing this block:

1. The clavicle

2. Posterior border of the clavicular head of the sternocleidomastoid muscle

3. External jugular vein (usually crosses the interscalene groove at the level of the trunks)

Maneuvers to Facilitate Landmark Identification

Identification of the interscalene groove can be made easier by performing the following steps:

• Ask the patient to reach for the ipsilateral knee with the limb to be blocked or passively pull the patient’s wrist inferiorly. This maneuver flattens the skin of the neck and helps identify both the scalene muscles and the external jugular vein.

• The sternocleidomastoid muscle can be accentuated by asking the patient to raise the head off the table (Figure 12-6).


FIGURE 12-6. Maneuver to extenuate the posterior border of the sternocleidomastoid muscle and external jugular vein by asking the patient to lift her head off of the table while looking away from the side to be blocked.

• The external jugular vein can be accentuated by asking the patient to perform a brief Valsalva maneuver.

• While palpating the interscalene groove, ask the patient to sniff forcefully. Sniffing tenses the scalene muscles, and the fingers of the palpating hand often fall into the interscalene groove.

The described landmarks should routinely be marked on the patient’s skin prior to performing the block.


• The proportions of the shoulder girdle, size of the neck, prominence of the muscles, and other anatomic features vary among patients. When in doubt, always perform a “reality check” and estimate three bony landmarks: the sternal notch, clavicle, and mastoid process. This helps identify the sternocleidomastoid muscle and its relations.


After cleaning the skin with an antiseptic solution, 1 to 3 mL of local anesthetic is infiltrated subcutaneously at the determined needle insertion site.


• During skin infiltration, care should be taken to infiltrate local anesthetic into the subcutaneous tissue plane only because the brachial plexus is very shallow at this location. A deeper needle insertion can result in deposition of local anesthetic into the plexus; this can result in nerve injury and/or make attempts at obtaining a motor response unsuccessful.

The fingers of the palpating hand should be gently but firmly pressed between the anterior and middle scalene muscles to shorten the skin-brachial plexus distance. The skin over the neck can be very mobile, and care should be taken to stabilize the fingers as well as to stretch the skin gently between the two fingers to ensure accuracy in needle advancement and redirection. The palpating hand should not be allowed to move during the entire block procedure to allow for precise redirection of the needle when necessary.


The goal is stimulation of the brachial plexus with a current intensity of 0.2–0.5 mA (0.1 ms). The following motor responses result in a similar success rate:

• Pectoralis muscle

• Deltoid muscle

• Triceps muscles

• Biceps muscle

• Any twitch of the hand or forearm

The needle is inserted 3–4 cm (approximately 2 fingerbreadths) above the clavicle and advanced at an angle almost perpendicular to the skin plane (Figure 12-7). The needle must never be oriented cephalad; a slight caudal orientation reduces a chance for an inadvertent insertion of the needle into the cervical spinal cord. The nerve stimulator should be initially set to deliver 0.8 to 1.0 mA (2 Hz, 0.1 ms). The needle is advanced slowly until stimulation of the brachial plexus is obtained. This typically occurs at a depth of 1 to 2 cm in most all patients. Once appropriate twitches of the brachial plexus are elicited, 25 to 35 mL of local anesthetic are injected slowly with intermittent aspiration to rule out intravascular injection.


FIGURE 12-7. Needle insertion for interscalene brachial plexus block. The needle is inserted between fingers positioned in the interscalene groove with a slight caudad orientation to decrease the chance of entrance in the cervical spinal cord. White arrow: insertion of the sternal head of the sternocleidomastoid muscle. Red arrows: posterior border of the sternocleidomastoid muscle. Blue arrow: external jugular vein. The insertion point for the block is often immediately posterior to the external jugular vein.

This “low-interscalene” approach differs from the classic description of the interscalene block, which uses the cricoid cartilage as a landmark. The principal advantage to the low approach is that the brachial plexus is more compact at the lower levels, and reliable coverage of the upper, middle, and lower trunks can be achieved with a single injection (Figure 12-8). In contrast, the classic approach may spare the lower trunk, which limits its use for forearm and elbow surgery.


FIGURE 12-8. Distribution of the mixture of local anesthetic and a radiopaque contrast after an interscalene brachial plexus injection. The arrows and the circle indicate “negative” contrast image of the roots of the brachial plexus.

When insertion of the needle does not result in upper extremity muscle stimulation, the following maneuvers can be used (Figure 12-9):


FIGURE 12-9. Maneuvers to obtain a motor response of the brachial plexus during electric nerve localization. When the motor response is not obtained on the initial needle pass, the needle is redirected anteriorly or posteriorly to the original insertion plane as shown in the figure.

1. Keep the palpating hand in the same position and the skin between the fingers stretched.

2. Withdraw the needle to the skin level, redirect it 15° posteriorly, and repeat the needle advancement.

3. Withdraw the needle to the skin level, redirect it 15° anteriorly, and repeat the needle insertion.


• The needle should never be advanced beyond 2.5 cm to avoid the risk of mechanical complications (cervical cord injury, pneumothorax, vascular puncture).

• Never inject when resistance (high pressure) on injection of local anesthetic is met. High resistance to injection (>15 psi) may indicate an intrafascicular needle placement. Instead, withdraw and/or rotate the needle slightly and reattempt the injection to assure absence of resistance.

• Stimulation of the brachial plexus with a higher stimulating current (e.g., >1.0 mA) results in an exaggerated response and unnecessary discomfort for the patient. In addition, an unpredictably strong response often causes dislodgment of the needle and a withdrawal reaction by the patient.

• Local anesthetic should not be injected when a motor response is obtained at a current intensity <0.2 mA because this is associated with intraneural needle placement.

• Intraneural injection of the trunks can lead not only to nerve injury but also retrograde backflow of local anesthetic toward neuraxial space, resulting in total spinal anesthesia.

• Care should always be taken to avoid attributing diaphragmatic and trapezius twitches to stimulation of the brachial plexus. Misinterpretation of these twitches is one of the most common causes of block failure.

• When in doubt, palpate the muscle that appears to be twitching to ensure the proper response.



TABLE 12-2 Common Problems During Nerve Localization and the Corrective Action


• Always assess the risk-benefit ratio of using large volumes and concentrations of long-acting local anesthetic for interscalene brachial plexus block.

• Smaller volumes and concentrations can be used successfully (e.g., 15–20 mL). However failure rate may be somewhat higher because the spread of local anesthetic can be seen as is the case with ultrasound guidance.

Block Dynamics and Perioperative Management

When stimulation with a low-intensity current and slow needle advancement are used, interscalene brachial plexus block is associated with minor patient discomfort. Excessive sedation is not only unnecessary but also potentially disadvantageous because patient cooperation during landmark assessment and block performance is beneficial. The administration of benzodiazepines also may decrease the tone of the scalene and sternocleidomastoid muscles, making their recognition more difficult. We typically use small doses of midazolam (e.g., 1–2 mg) and/or short acting opioid (e.g., alfentanyl 250-500 mcg), so that the patient is comfortable and cooperative during nerve localization.

The onset time of this block is relatively short. The first sign of the blockade is typically a loss of coordination of the shoulder and arm muscles. This sign is seen sooner than the onset of a sensory blockade or a temperature change and, when observed within 1 to 2 minutes after injection, is highly predictive of a successful brachial plexus blockade. In patients undergoing shoulder arthroscopic procedures, it is important to note that the arthroscopic portals are often inserted outside the cutaneous distribution of the interscalene block. Local infiltration at the site of the incision by the surgeon is all that is needed because the entire shoulder joint and deep tissues are anesthetized with the interscalene block alone.

Education of the patient regarding block effects and side effects is important with interscalene block. Patients should be instructed to take prescribed oral analgesics and use ice packs before the block resolves. This regimen is of particular importance with ambulatory patients who may experience significant pain after discharge if they are unprepared.


• Due to blockade of neighboring neural structures, many patients develop a hoarse voice (recurrent laryngeal nerve), mild ipsilateral ptosis and miosis, and nasal congestion (Horner syndrome: sympathetic chain) following an interscalene block. A proper explanation and reassurance are all that such patients need.

• Interscalene block inevitably results in ipsilateral diaphragmatic paralysis (a phrenic nerve block). The significance of this is debated, and avoidance of this block is suggested in patients with severe chronic respiratory disease, especially restrictive lung diseases. Patients with chronic obstructive pulmonary disease often already have diaphragms that are flattened and inefficient, and the subsequent paresis is thought to have a limited effect on these individuals.

• We avoid the use of this block only in patients whose breathing involves the use of accessory respiratory muscles.

• Appropriate intravenous sedation, communication with the patient, lifting drapes off the patient’s face, and shielding the ears from noise are all necessary ingredients for success with interscalene blocks in patients undergoing shoulder surgery.

Continuous Interscalene Block

A continuous interscalene block is a more advanced regional anesthesia technique, and adequate experience with the single-injection technique is necessary. Paradoxically, although a single-injection interscalene block is one of the easiest intermediate techniques to perform and master, placement of the catheter can be one of the more technically challenging procedures. This is because the shallow position of the brachial plexus does not allow for an easy needle stabilization during catheter advancement and catheters can easily get dislodged during needle withdrawal. Otherwise, the technique is similar to the single-injection procedure, apart from a slight difference in the angle of the needle. This procedure provides excellent analgesia in patients following shoulder, arm, and elbow surgery.


A standard regional anesthesia tray is prepared with the following equipment:

• Sterile towels and gauze packs

• 2 × 20-mL syringes containing local anesthetic

• Sterile gloves, marking pen, and surface electrode

• A 3-mL syringe and 25-gauge needle with local anesthetic for skin infiltration

• Peripheral nerve stimulator

• Catheter kit (including a 4- to 5-cm large-gauge stimulating needle and catheter)

Kits come in two varieties based on catheter construction: nonstimulating (conventional) and stimulating catheters. During the placement of a conventional nonstimulating catheter, the stimulating needle is first advanced until appropriate twitches are obtained. Then, 5 to 10 mL of local anesthetic or other injectate (e.g., dextrose 5% in water) can be injected to “open up” a space for the catheter to advance freely without resistance. The catheter is then inserted through the needle approximately 3 to 5 cm beyond the tip of the needle. The needle is withdrawn, the catheter is secured, and the remaining local anesthetic is injected via the catheter. Stimulating catheters are insulated and have a filament or core that transmits current to a bare metal tip. After obtaining twitches with the needle, the catheter is advanced with the nerve stimulator connected until the anesthesiologist is satisfied with the quality of the motor response. If the twitch is lost, the catheter may be withdrawn until it reappears, and the catheter is readvanced. This method requires no conducting solution to be injected through the needle (i.e., local anesthetic, saline) before catheter advancement, or difficulty obtaining a motor response will result.

Landmarks and Patient Positioning

The patient is in the same position as for the single-injection technique. However, it is imperative that the anesthesiologist assume an ergonomic position to allow maneuvering during catheter insertion. It is often easiest for the clinician to stand at the head of the bed to avoid inserting the needle at an awkward angle because it is desirable to advance the catheter in an inferolateral direction (i.e., the same direction as the plexus). It is also important that all equipment, including the catheter, be immediately available and prepared in advance because small movements of the needle that might occur while trying to prepare the catheter can result in dislodging the needle from its position in the brachial plexus sheath.

The landmarks for a continuous interscalene brachial plexus block are similar to those for the single-shot technique:

1. Clavicle

2. Posterior border of the clavicular head of the sternocleidomastoid muscle

3. External jugular vein


The subcutaneous tissue at the projected site of needle insertion is anesthetized with local anesthetic. The block needle is attached to a nerve stimulator (1.0 mA, 2 Hz, 0.1 ms). With this technique, the palpating hand must firmly stabilize the skin to facilitate needle insertion and insertion of the catheter. A 3- to 5-cm block needle is inserted in the interscalene groove, with a more pronounced caudal angle than the single-shot technique, and advanced until the brachial plexus twitch is elicited at 0.2 to 0.5 mA. Precautions should be taken to avoid inserting the needle through the external jugular vein because this invariably results in prolonged oozing from the site of puncture. This can be avoided by retracting the external jugular vein and inserting the needle slightly in front of or posteriorly to the external jugular vein. Paying meticulous attention to the position of the needle, the catheter is inserted no more than 3 to 5 cm beyond the tip of the needle (Figure 12-10).


FIGURE 12-10. Insertion of a catheter into the interscalene space. Insertion of the catheter often requires lowering of the needle angle to facilitate catheter passage. Catheters are typically inserted 3–5 cm past the needle tip to prevent inadvertent removal.


• The most challenging aspect of this technique is stabilization of the needle for catheter insertion after the brachial plexus is localized.

• When the needle encounters the brachial plexus at a very shallow location, it is helpful to have an assistant advance the catheter in a sterile fashion to ensure that the needle does not move from its original position.

• In patients with less than ideal landmarks, it may be prudent to first use a single-shot needle to localize the brachial plexus and to determine the needle insertion point and proper angulation before inserting a large-gauge continuous block needle.

The catheter is secured using an adhesive skin preparation such as benzoin, followed by application of a clear dressing. Several securing devices are also commercially available. The infusion port should be clearly marked “continuous nerve block,” and the catheter should be carefully checked for intravascular placement before administering a bolus or infusion of local anesthetics.

Management of the Continuous Infusion

Continuous infusion is initiated after an initial bolus of dilute local anesthetic is administered through the needle or catheter. For this purpose, we routinely use 0.2% ropivacaine 15 to 20 mL. Diluted bupivacaine or levobupivacaine are suitable also but can result in greater motor blockade. Other adjuvants (clonidine, epinephrine, or opioids) do not appear to be of benefit in continuous nerve blocks. The infusion is maintained at 5 mL/h when a dose of patient-controlled regional analgesia (PCRA) (5 mL every 30-60 minutes) is planned. Additional catheter management directions are also discussed in Chapter 7.

Inpatients should be seen and instructed on the use of PCRA at least once a day. During each visit, the insertion site should be checked for erythema and swelling and the extent of motor and sensory blockade documented. The infusion and PCRA dose should be adjusted accordingly. When the patient complains of breakthrough pain, the extent of the blockade should be checked first. A bolus of dilute local anesthetic (e.g., 10–15 mL of 0.2% ropivacaine) can be injected to reactivate the catheter. Increasing the infusion rate alone never results in improvement in analgesia. When the bolus fails to result in blockade after 30 minutes, the catheter should be considered to have migrated and should be removed. Alternatively, where equipment and expertise is available, the position of the catheter can be confirmed ultrasonographically by documenting the location of an injection bolus through the catheter. Every patient receiving a continuous nerve block infusion should be prescribed an immediately available alternative pain management protocol because incomplete analgesia and catheter dislodgment can occur. Complications of interscalane brachial plexus blocks and means of their prevention are listed in Table 12-3.

TABLE 12-3 Complications and How to Avoid Them



• Breakthrough pain in patients undergoing continuous infusion is always managed by administering a bolus of local anesthetic. Increasing the rate of infusion alone is rarely adequate.

• For patients on the ward, a small bolus (e.g. 5 mL) of a shorter acting, higher concentration epinephrine-containing local anesthetic (e.g., 1% mepivacaine or lidocaine with 1:300,000 epinephrine) can be used to test the position of the catheter; failure to obtain a sensory block indicates catheter migration.




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Iskandar H, Wakim N, Benard A, et al. The effects of interscalene brachial plexus block on humeral arterial blood flow: a Doppler ultrasound study. Anesth Analg. 2005;101:279-281.

Jafari S, Kalstein AI, Nasrullah HM, Hedayatnia M, Yarmush JM, SchianodiCola J. A randomized, prospective, double-blind trial comparing 3% chloroprocaine followed by 0.5% bupivacaine to 2% lidocaine followed by 0.5% bupivacaine for interscalene brachial plexus block. Anesth Analg. 2008;107:1746-1750.

Karaca P, Hadžić A, Yufa M, et al. Painful paresthesiae are infrequent during brachial plexus localization using low-current peripheral nerve stimulation. Reg Anesth Pain Med. 2003;28:380-383.

Kempen PM, O’Donnell J, Lawler R, Mantha V. Acute respiratory insufficiency during interscalene plexus block. Anesth Analg. 2000;90:1415-1416.

Klein SM, Nielsen KC, Martin A, et al. Interscalene brachial plexus block with continuous intraarticular infusion of ropivacaine. Anesth Analg. 2001;93:601-605.

Klein SM, Pietrobon R, Nielsen KC, Warner DS, Greengrass RA, Steele SM. Peripheral nerve blockade with long-acting local anesthetics: a survey of the Society for Ambulatory Anesthesia. Anesth Analg.2002;94: 71-76.

Koorn R, Tenhundfeld Fear KM, Miller C, Boezaart A. The use of cervical paravertebral block as the sole anesthetic for shoulder surgery in a morbid patient: a case report. Reg Anesth Pain Med. 2004;29:227-229.

Krone SC, Chan VW, Regan J, et al. Analgesic effects of low-dose ropivacaine for interscalene brachial plexus block for outpatient shoulder surgery—a dose-finding study. Reg Anesth Pain Med. 2001;26:439-443.

Langen KE, Candido KD, King M, Marra G, Winnie AP. The effect of motor activity on the onset and progression of brachial plexus block with bupivacaine: a randomized prospective study in patients undergoing arthroscopic shoulder surgery. Anesth Analg. 2008;106:659-663.

Lierz P, Gustorff B, Felleiter P. Pain therapy with interscalene local anesthetic. Anesth Analg. 2001;93:1624.

Liguori GA, Zayas VM, YaDeau JT, et al. Nerve localization techniques for interscalene brachial plexus blockade: a prospective, randomized comparison of mechanical paresthesia versus electrical stimulation. Anesth Analg. 2006;103:761-767.

Long TR, Wass CT, Burkle CM. Perioperative interscalene blockade: an overview of its history and current clinical use. J Clin Anesth. 2002;14:546-556.

Marhofer P, Harrop-Griffiths W, Willschke H, Kirchmair L. Fifteen years of ultrasound guidance in regional anaesthesia: Part 2—recent developments in block techniques. Br J Anaesth. 2010;104:673-683.

Maurer K, Ekatodramis G, Rentsch K, Borgeat A. Interscalene and infraclavicular block for bilateral distal radius fracture. Anesth Analg. 2002;94:450-452.

Moayeri N, Bigeleisen PE, Groen GJ. Quantitative architecture of the brachial plexus and surrounding compartments, and their possible significance for plexus blocks. Anesthesiology. 2008;108:299-304.

Nadig M, Blumenthal S, Ekatodramis G, Borgeat A. Interscalene brachial plexus anesthesia and analgesia for open shoulder surgery: what about pharmacokinetics? Anesth Analg. 2003;97: 605-606.

Naik VN, Perlas A, Chandra DB, Chung DY, Chan VW. An assessment tool for brachial plexus regional anesthesia performance: establishing construct validity and reliability. Reg Anesth Pain Med. 2007;32:41-45.

Neal JM, McDonald SB, Larkin KL, Polissar NL. Suprascapular nerve block prolongs analgesia after nonarthroscopic shoulder surgery but does not improve outcome. Anesth Analg. 2003;96:982-986.

Orebaugh SL, Williams BA, Vallejo M, Kentor ML. Adverse outcomes associated with stimulator-based peripheral nerve blocks with versus without ultrasound visualization. Reg Anesth Pain Med. 2009;34:251-255.

Paqueron X, Gentili ME, Willer JC, Coriat P, Riou B. Time sequence of sensory changes after upper extremity block: swelling sensation is an early and accurate predictor of success. Anesthesiology. 2004;101:162-168.

Patel V, Hadzic A, Gadsden J, Gandhi K: An electrocardiopraph artifact caused by peripheral nerve stimulation during an interscalene brachial plexus nerve block. Reg Anesth Pain Med 2010; 35:118-9.

Raj PP. Textbook of Regional Anesthesia. London, UK: Churchill Livingstone; 2002.

Reuben SS. Interscalene block superior to general anesthesia. Anesthesiology. 2006;104:207.

Robaux S, Bouaziz H, Boisseau N, Raucoules-Aime M, Laxenaire MC. Persistent phrenic nerve paralysis following interscalene brachial plexus block. Anesthesiology. 2001;95:1519-1521.

Rose M, Ness TJ. Hypoxia following interscalene block. Reg Anesth Pain Med. 2002;27:94-96.

Sardesai AM, Patel R, Denny NM, et al. Interscalene brachial plexus block: can the risk of entering the spinal canal be reduced? A study of needle angles in volunteers undergoing magnetic resonance imaging. Anesthesiology. 2006;105:9-13.

Sciard D, Matuszczak M, Gebhard R, Kocieniewska D. Interscalene block-, sedation-, lateral positioning-, and hydralazine-induced hypotension: is it really prudent? Anesthesiology. 2002;97:280-281.

Sia S, Sarro F, Lepri A, Bartoli M. The effect of exogenous epinephrine on the incidence of hypotensive/bradycardic events during shoulder surgery in the sitting position during interscalene block. Anesth Analg. 2003;97:583-588.

Silverstein WB, Saiyed MU, Brown AR. Interscalene block with a nerve stimulator: a deltoid motor response is a satisfactory endpoint for successful block. Reg Anesth Pain Med. 2000;25: 356-359.

Singelyn FJ. Difficult insertion of interscalene brachial plexus catheter. Anesth Analg. 2001;92:1074.

Singelyn FJ, Lhotel L, Fabre B. Pain relief after arthroscopic shoulder surgery: a comparison of intraarticular analgesia, suprascapular nerve block, and interscalene brachial plexus block. Anesth Analg. 2004;99:589-592.

Sukhani R, Candido KD. Interscalene brachial plexus block: shoulder paresthesia versus deltoid motor response: revisiting the anatomy to settle the controversy. Anesth Analg. 2002;95:1818; author reply 1818-1819.

Tonidandel WL, Mayfield JB. Successful interscalene block with a nerve stimulator may also result after a pectoralis major motor response. Reg Anesth Pain Med. 2002;27:491-493.

Urmey WF. Interscalene block: the truth about twitches. Reg Anesth Pain Med. 2000;25:340-342.

Urmey WF. Is a deltoid twitch a satisfactory endpoint for all interscalene blocks? Reg Anesth Pain Med. 2001;26:183.

Urmey WF, Stanton J. Inability to consistently elicit a motor response following sensory paresthesia during interscalene block administration. Anesthesiology. 2002;96:552-554.

Walton JS, Folk JW, Friedman RJ, Dorman BH. Complete brachial plexus palsy after total shoulder arthroplasty done with interscalene block anesthesia. Reg Anesth Pain Med. 2000;25:318-321.

Weber SC, Parise CA, Jain R. Interscalene block superior to general anesthesia: a discussion of the conclusions regarding these two anesthesia techniques. Anesthesiology. 2006;104:208.

Whitaker EE, Edelman AL, Wilkens JH, Richman JM: Severe hypotension after interscalene block for outpatient shoulder surgery: a case report. J Clin Anesth 2010;22:132-134.

White JL. Catastrophic complications of interscalene nerve block. Anesthesiology. 2001;95:1301.

Winnie AP. Interscalene brachial plexus block. Anesth Analg. 1970;49:455-466.

Winnie AP. Plexus Anesthesia, Perivascular Techniques of Brachial Plexus Block. 2nd ed. Philadelphia, PA: Saunders; 1990.

Wong GY, Brown DL, Miller GM, Cahill DR. Defining the cross-sectional anatomy important to interscalene brachial plexus block with magnetic resonance imaging. Reg Anesth Pain Med. 1998;23:77-80.

Wurm WH, Concepcion M, Sternlicht A, et al. Preoperative interscalene block for elective shoulder surgery: loss of benefit over early postoperative block after patient discharge to home. Anesth Analg. 2003;97:1620-1626.

Continuous Interscalene Brachial Plexus Block

Blumenthal S, Nadig M, Borgeat A. The analgesic effect of interscalene block using clonidine as an analgesic for shoulder arthroscopy: where is the catheter? Anesth Analg. 2003;97:928.

Borgeat A, Aguirre J, Curt A. Case scenario: neurologic complication after continuous interscalene block. Anesthesiology. 2010;112:742-745.

Borgeat A, Dullenkopf A, Ekatodramis G, Nagy L. Evaluation of the lateral modified approach for continuous interscalene block after shoulder surgery. Anesthesiology. 2003;99:436-442.

Borgeat A, Perschak H, Bird P, Hodler J, Gerber C. Patient-controlled interscalene analgesia with ropivacaine 0.2% versus patient-controlled intravenous analgesia after major shoulder surgery: effects on diaphragmatic and respiratory function. Anesthesiology. 2000;92:102-108.

Borgeat A, Aguirre J, Curt A: Case scenario: neurologic complication after continuous interscalene block. Anesthesiology 2010; 112: 742-5.

Capdevila X, Dadure C, Bringuier S, et al. Effect of patient-controlled perineural analgesia on rehabilitation and pain after ambulatory orthopedic surgery: a multicenter randomized trial. Anesthesiology. 2006;105:566-573.

Capdevila X, Jaber S, Pesonen P, Borgeat A, Eledjam JJ. Acute neck cellulitis and mediastinitis complicating a continuous interscalene block. Anesth Analg. 2008;107:1419-1421.

Chelly JE, Casati A, Fanelli G. Continuous Peripheral Nerve Block Techniques: An Illustrated Guide. London, UK: Mosby International; 2001.

Clendenen SR, Robards CB, Wang RD, Greengrass RA. Case report: continuous interscalene block associated with neck hematoma and postoperative sepsis. Anesth Analg. 2010;110:1236-1238.

Clendenen SR, Robards CB, Wang RD, Greengrass RA: Case report: continuous interscalene block associated with neck hematoma and postoperative sepsis. Anesth Analg 2010;110: 1236-1238.

Coleman MM, Chan VW. Continuous interscalene brachial plexus block. Can J Anaesth. 1999;46:209-214.

Despond O, Kohut GN. Broken interscalene brachial plexus catheter: surgical removal or not? Anesth Analg. 2010;110:643-644.

Dooley J, Fingerman M, Melton S, Klein SM: Contralateral local anesthetic spread from an outpatient interscalene catheter. Can J Anaesth 2010;10:936-939.

Ekatodramis G, Borgeat A, Huledal G, Jeppsson L, Westman L, Sjovall J. Continuous interscalene analgesia with ropivacaine 2 mg/ml after major shoulder surgery. Anesthesiology. 2003;98:143-150.

Ekatodramis G, Macaire P, Borgeat A. Prolonged Horner syndrome due to neck hematoma after continuous interscalene block. Anesthesiology. 2001;95:801-803.

Faust A, Fournier R, Hagon O, Hoffmeyer P, Gamulin Z. Partial sensory and motor deficit of ipsilateral lower limb after continuous interscalene brachial plexus block. Anesth Analg. 2006;102:288-290.

Fredrickson MJ, Abeyeskera A, Price DJ, Wong AC: Patient-initiated mandatory boluses for ambulatory continuous interscalene analgesia: an effective strategy for optimizing analgesia and minimizing side-effects. Br J Anaesth2011; 106:239-245.

Fredrickson MJ, Ball CM, Dalgleish AJ. Successful continuous interscalene analgesia for ambulatory shoulder surgery in a private practice setting. Reg Anesth Pain Med. 2008;33:122-128.

Fredrickson MJ, Ball CM, Dalgeish AJ: Analgesic effectiveness of a continuous versus single-injection intersclane block for minor arthroscopic shoulder surgery. Reg Anesth Pain Med 2010;35:28-33.

Fredrickson MJ, Ball CM, Dalgleish AJ: A prospective randomized comparison of ultrasound guidance versus neurotimulation for interscalene catheter placement. Reg Anesth Pain Med 2009;34: 590-594.

Hofmann-Kiefer K, Eiser T, Chappell D, Leuschner S, Conzen P, Schwender D. Does patient-controlled continuous interscalene block improve early functional rehabilitation after open shoulder surgery? Anesth Analg. 2008;106:991-996.

Horlocker TT, O’Driscoll SW, Dinapoli RP. Recurring brachial plexus neuropathy in a diabetic patient after shoulder surgery and continuous interscalene block. Anesth Analg. 2000;91:688-690.

Horlocker TT, Weiss WT, Olson CA. Whodunnit: the mysterious case of mediastinitis after continuous interscalene block. Anesth Analg. 2008;107:1095-1097.

Ilfeld BM, Enneking FK. A portable mechanical pump providing over four days of patient-controlled analgesia by perineural infusion at home. Reg Anesth Pain Med. 2002;27:100-104.

Ilfeld BM, Morey TE, Thannikary LJ, Wright TW, Enneking FK. Clonidine added to a continuous interscalene ropivacaine perineural infusion to improve postoperative analgesia: a randomized, double-blind, controlled study. Anesth Analg. 2005;100:1172-1178.

Ilfeld BM, Morey TE, Wright TW, Chidgey LK, Enneking FK. Continuous interscalene brachial plexus block for postoperative pain control at home: a randomized, double-blinded, placebo-controlled study. Anesth Analg. 2003;96:1089-1095.

Ilfeld BM, Morey TE, Wright TW, Chidgey LK, Enneking FK. Interscalene perineural ropivacaine infusion:a comparison of two dosing regimens for postoperative analgesia. Reg Anesth Pain Med. 2004;29:9-16.

Ilfeld BM, Vandenborne K, Duncan PW, et al. Ambulatory continuous interscalene nerve blocks decrease the time to discharge readiness after total shoulder arthroplasty: a randomized, triple-masked, placebo-controlled study. Anesthesiology. 2006;105:999-1007.

Ilfeld BM, Wright TW, Enneking FK, Morey TE. Joint range of motion after total shoulder arthroplasty with and without a continuous interscalene nerve block: a retrospective, case-control study. Reg Anesth Pain Med. 2005;30:429-433.

Klein SM, Grant SA, Greengrass RA, et al. Interscalene brachial plexus block with a continuous catheter insertion system and a disposable infusion pump. Anesth Analg. 2000;91:1473-1478.

Le LT, Loland VJ, Mariano ER, et al. Effects of local anesthetic concentration and dose on continuous interscalene nerve blocks: a dual-center, randomized, observer-masked, controlled study. Reg Anesth Pain Med. 2008;33:518-525.

Lehtipalo S, Koskinen LO, Johansson G, Kolmodin J, Biber B. Continuous interscalene brachial plexus block for postoperative analgesia following shoulder surgery. Acta Anaesthesiol Scand. 1999;43:258-264.

Macfarlane AJ, Brull R. Continuous interscalene block for open shoulder surgery. Anesth Analg. 2008;107:726.

Maurer K, Ekatodramis G, Hodler J, Rentsch K, Perschak H, Borgeat A. Bilateral continuous interscalene block of brachial plexus for analgesia after bilateral shoulder arthroplasty. Anesthesiology. 2002;96:762-764.

Pere P, Pitkanen M, Rosenberg PH, et al. Effect of continuous interscalene brachial plexus block on diaphragm motion and on ventilatory function. Acta Anaesthesiol Scand. 1992; 36:53-57.

Rawal N, Allvin R, Axelsson K, et al. Patient-controlled regional analgesia (PCRA) at home: controlled comparison between bupivacaine and ropivacaine brachial plexus analgesia. Anesthesiology. 2002;96:1290-1296.

Sandefo I, Bernard JM, Elstraete V, et al. Patient-controlled interscalene analgesia after shoulder surgery: catheter insertion by the posterior approach. Anesth Analg. 2005;100:1496-1498.

Sardesai AM, Chakrabarti AJ, Denny NM. Lower lobe collapse during continuous interscalene brachial plexus local anesthesia at home. Reg Anesth Pain Med. 2004;29:65-68.

Singelyn FJ, Seguy S, Gouverneur JM. Interscalene brachial plexus analgesia after open shoulder surgery: continuous versus patient-controlled infusion. Anesth Analg. 1999;89: 1216-1220.

Souron V, Reiland Y, Delaunay L. Pleural effusion and chest pain after continuous interscalene brachial plexus block. Reg Anesth Pain Med. 2003;28:535-538.

Souron V, Reiland Y, De Traverse A, Delaunay L, Lafosse L. Interpleural migration of an interscalene catheter. Anesth Analg. 2003;97:1200-1201.

Stevens MF, Werdehausen R, Golla E, et al. Does interscalene catheter placement with stimulating catheters improve postoperative pain or functional outcome after shoulder surgery? A prospective, randomized and double-blinded trial. Anesth Analg. 2007;104:442-447.

Vranken JH, van der Vegt MH, Zuurmond WW, Pijl AJ, Dzoljic M. Continuous brachial plexus block at the cervical level using a posterior approach in the management of neuropathic cancer pain. Reg Anesth Pain Med. 2001;26:572-575.

Wiegel M, Gottschaldt U, Hennebach R, Hirschberg T, Reske A. Complications and adverse effects associated with continuous peripheral nerve blocks in orthopedic patients. Anesth Analg. 2007;104:1578-1582.

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