Hadzic's Peripheral Nerve Blocks and Anatomy for Ultrasound-Guided Regional Anesthesia, 2nd

7. Continuous Peripheral Nerve Blocks in Outpatients

Brian M. Ilfeld, Elizabeth M. Renehan and F. Kayser Enneking


• Single-injection nerve blocks provide up to 16 hours of postoperative analgesia.

• Portable infusion pumps allow outpatients to receive continuous nerve blocks.

More than 40% of ambulatory patients experience moderate to severe postoperative pain at home following orthopedic procedures.1 Up to 16 hours of analgesia may be provided by single-injection peripheral nerve blocks with long-acting local anesthetics. However, following block resolution, ambulatory patients must usually rely on oral opioids to control pain. Unfortunately, opioids are associated with undesirable side effects, such as pruritus, nausea and vomiting, sedation, and constipation. To improve postoperative analgesia following ambulatory surgery, there has been an increasing interest in providing “perineural local anesthetic infusions,” also called, “continuous peripheral nerve blocks,” to outpatients. This technique involves the percutaneous insertion of a catheter directly adjacent to the peripheral nerve(s) supplying the surgical site. Local anesthetic is then infused via the catheter providing potent, site-specific analgesia. Outpatients may theoretically experience the same level of analgesia previously afforded only to those remaining hospitalized by combining the perineural catheter with a portable infusion pump.

In 1946, Ansbro first described continuous regional blockade using a cork to stabilize a needle placed adjacent to the brachial plexus divisions to provide a “continuous” supraclavicular block.2 However, for decades patients were required to remain hospitalized because the available pumps used to infuse local anesthetic were large, heavy, and technically sophisticated. It was not until 52 years later that Rawal described outpatient perineural infusion using a percutaneous catheter and a small lightweight, portable infusion pump.3

Advantages and Evidence

• Significant decreases in postoperative pain and opioid side effects are possible.

• Earlier home discharge is possible for a select subset of hospitalized patients.

Following Rawal’s article, case reports or series of ambulatory perineural infusion were described via catheters in various anatomic locations, including paravertebral,4 interscalene,5–7intersternocleidomastoid,8 infraclavicular,6axillary,9 psoas compartment,9,10 femoral,9,11 fascia iliaca,5 sciatic/Labat,9,10 sciatic/popliteal,6,12 and tibial nerve.6 Ambulatory continuous peripheral nerve blocks in pediatric patients have also been reported in patients as young as 8 years of age.13 However, Klein et al provided the first prospective evidence quantifying infusion benefits in 2000.14

This randomized, double-masked, placebo-controlled investigation by Klein et al involved subjects undergoing open rotator cuff repair who received an interscalene block and perineural catheter preoperatively, and they were randomized to receive either perineural ropivacaine 0.2% or normal saline postoperatively (10 mL/h). Patients receiving perineural placebo averaged a 3 on a visual analog pain scale of 0 to 10, compared with a 1 for subjects receiving ropivacaine. Although a portable pump was used, patients remained hospitalized during local anesthetic infusion <24 hours, and catheters were removed by investigators prior to home discharge. Patients had access to intravenous morphine via patient-controlled opioid analgesia because the investigators “felt compelled to provide more than oral analgesics,” since patients remained hospitalized.14 As a result, patients receiving normal saline theoretically received a greater degree of analgesia than that available to ambulatory patients who must rely on oral instead of intravenous opioids. Consequently, although these data suggested perineural infusion may improve postoperative analgesia following hospital discharge, the extent of improvement for patients actually at home remained unknown.

Data involving perineural infusion in outpatients were subsequently provided in four randomized double-masked, placebo-controlled studies.15–18 Patients receiving perineural local anesthetic achieved both clinically and statistically significant lower resting and breakthrough pain scores compared with those using exclusively oral opioids for analgesia (Figure 7-1). In addition, they required dramatically fewer oral analgesics to achieve their improved level of analgesia (Figure 7-1). Preoperatively, subjects scheduled for moderately painful procedures had a perineural catheter placed: an infraclavicular catheter for hand/forearm procedures,15 a popliteal catheter for foot/ankle surgeries,16,18 or an interscalene catheter for shoulder procedures.17 Postoperatively, patients received either perineural local anesthetic or normal saline and were followed at home for up to 60 hours. All patients were instructed to use a bolus from their infusion pump for breakthrough pain and oral analgesics if this maneuver failed. In patients with an interscalene catheter following shoulder surgery, the local anesthetic infusion provided analgesia so complete that 80% of patients receiving ropivacaine required one or fewer opioid tablets per day during their infusion, and they reported average resting pain <1.5 on a scale of 0–10.17 This compares with all patients receiving placebo requiring four or more opioid tablets per day, beginning the evening of surgery, and reporting average resting pain scores between 3 and 4. For breakthrough pain, the differences between treatment groups were even more pronounced in all of these four placebo-controlled studies (Figure 7-1).




FIGURE 7-1. Effects of interscalene and sciatic/popliteal perineural infusion of either ropivacaine or placebo on average pain at rest (panels A and D), worst pain overall (panels B and E), and opiate use (panels C and F) following moderately painful shoulder or lower extremity surgery (scale: 0–10). Each opiate tablet consisted of oxycodone, 5 mg. Note: The infusion was discontinued after postoperative day 2 as indicated by the horizontal lines. Data are expressed as median (horizontal bar) with 25th–75th (box) and 10th–90th (whiskers) percentiles for patients randomly assigned to receive either 0.2% ropivacaine or 0.9% saline placebo. For tightly clustered data (e.g., panel A, postoperative days 0 and 1, ropivacaine group), the median approximated the 10th and 25th percentile values. In this case, the median is zero and only the 75th and 90th percentiles are clearly noted; p < 0.05: *, compared with saline for a given postoperative day. Reproduced with permission.16,17

Additional benefits related to improved analgesia were experienced by patients who received perineural local anesthetic. Of patients receiving perineural ropivacaine, 0 to 30% reported insomnia due to pain, compared with 60 to 70% of patients receiving placebo.15–17 Additionally, awakenings from sleep because of pain averaged 0.0 to 0.2 times on the first postoperative night, compared with 2.0 to 2.3 times for patients using only oral opioids.15–17 Using fewer opioid tablets was associated with a lower rate of nausea, vomiting, pruritus, and sedation.15–18 Satisfaction with postoperative analgesia was both clinically and statistically higher for patients receiving local anesthetic.15–18Finally, patients with popliteal local anesthetic infusion rated their “quality of recovery” (0–100; 100 = highest) an average of 96 compared with 83 for patients receiving placebo.18 Whether these demonstrated benefits result in an improvement in patients’ health-related quality-of-life remains unexamined.19 Also uninvestigated to date is the relative superiority of one location over another for similar procedures (e.g., axillary vs. infraclavicular for hand surgery).

The possible advantages of using outpatient perineural infusion to allow earlier discharge of patients who require potent analgesia has only recently been explored. Individual benefits of a shorter hospitalization may include a decrease in nosocomial infection,20,21 harmful medical errors,22,23 and increases in health-related quality-of-life.19 Societal benefits include a potentially enormous cost savings.24–26 Using ambulatory perineural infusion, patients have been discharged home directly from the recovery room following total elbow (unpublished data, Ilfeld et al, 2004) and shoulder replacement,27 and on the first postoperative day following total hip (unpublished data, Ilfeld et al, 2004) and knee replacement.28 Additional data are required to define the appropriate subset of patients and assess the benefits and incidence of complications associated with this practice.

Patient Selection

• Outpatient infusion is often limited to patients expected to have moderate pain.

• Appropriate patient selection is crucial for safe outpatient infusion.

Many investigators have limited the use of ambulatory infusion to patients who are expected to have moderate or severe postoperative pain >24 hours that is not easily managed with oral opioids. This practice is in an attempt to balance the potential benefits of this technique with the potential risks,29,30 financial cost, and patient inconvenience of carrying an infusion pump and up to 600 mL of local anesthetic.27However, outpatient infusion may be used following mildly painful procedures—defined here as usually well-managed with oral opioids—to decrease opioid requirements and opioid-related side effects.3,31Appropriate patient selection is crucial for safe outpatient infusion because not all patients desire, or are capable of accepting, the extra responsibility that comes with the catheter and pump system. Because some degree of postoperative cognitive dysfunction is common following surgery,32 patients are often required to have a “caretaker” during infusion.15–17,33–36 Whether a caretaker is necessary for one night or for the entire duration of infusion remains unresolved.37 If removal of the catheter is expected to occur at home, then a caretaker willing to perform this procedure must be available at the infusion conclusion if the patient is unwilling or unable to do this themselves (e.g., psoas compartment catheter).

In medically unsupervised outpatients, complications may take longer to identify or be more difficult to manage than for hospitalized patients. Therefore, hepatic or renal insufficiency have been relative contraindications to outpatient infusion in an effort to avoid local anesthetic toxicity.38 For infusions that may effect the phrenic nerve and ipsilateral diaphragm function (e.g., interscalene or cervical paravertebral catheters), patients with heart or lung disease are often excluded because continuous interscalene local anesthetic infusions have been shown to cause frequent ipsilateral diaphragm paralysis.39Conservative application of this technique is warranted until additional investigation of hospitalized medically supervised patients documents its safety,40,41 although the effect on overall pulmonary function may be minimal for relatively healthy patients.42

Selection of Insertion Technique

• The optimal equipment and insertion techniques have yet to be determined.

• A “test dose” of local anesthetic and epinephrine via the catheter is mandatory.

• Securing the catheter adequately is of paramount concern.

In a substantial number of cases—as high as 40% in some reports43—inaccurate catheter placement may occur.17,44,45 This issue is of critical importance for outpatients because catheter replacement is not an option after leaving the medical facility. Many techniques and types of equipment have been described for catheter insertion. Using one common technique, the initial local anesthetic bolus is given via the needle, followed by catheter placement. However, using this method, it is possible to provide a successful surgical block but inaccurate catheter placement.17 For ambulatory patients, the inadequate perineural infusion often will not be detected until after surgical block resolution following home discharge.17 Using another technique, investigators have first inserted the catheter and then administered a bolus of local anesthetic via the catheter, with a reported failure rate of 1 to 8%.46,47

In an attempt to further improve catheter-placement success rates, “stimulating” catheters have been developed that deliver current to the catheter tip.48 This design provides feedback on the positional relationship of the catheter tip to the target nerve prior to local anesthetic dosing.33,34 To date, there are no studies comparing stimulating and nonstimulating catheters. However, there is limited evidence that passing current via the catheter may improve the accuracy of catheter placement.49 The optimal placement techniques and equipment for ambulatory perineural infusion have yet to be determined and require further investigation.50 A local anesthetic and epinephrine “test dose” should be injected via the catheter in an effort to identify intrathecal,51 epidural,52 or intravascular53 placement before infusion initiation, regardless of the equipment/technique used.

Local Anesthetic and Adjuvant Selection

• Most outpatient infusions reported involved ropivacaine or bupivacaine.

• No adjuvant added to local anesthetic has been demonstrated to be of benefit.

Although perineural infusions of levobupivacaine54 and shorter-acting agents have been reported,55–57 most publications have involved ropivacaine 0.2% or bupivacaine 0.125 to 0.25%. Currently, there is insufficient information to determine if there is an optimal local anesthetic (or concentration) for ambulatory infusions.31,54,58 The optimal concentration and infusion rate for a particular catheter site in relationship to the degree of motor block has not been established either.

Patient-Controlled Regional Analgesia

• Providing patients the ability to self-administer bolus doses maximizes benefits

• The optimal basal rate, bolus volume, and lockout time have not been determined

• Commonly used: basal 4–8 mL/h, bolus 2–5 mL, and lockout time 20–60 minutes

Available inpatient and outpatient data suggest that following procedures producing moderate to severe pain, providing patients with the ability to self-administer local anesthetic doses (patient-controlled regional analgesia) increases perioperative benefits and/or decreases local anesthetic consumption.33,34,36,59–61 However, no information is available to base recommendations on the optimal basal rate, bolus volume, or lockout period, other than for interscalene catheters.33 Until recommendations based on prospectively collected data are published, practitioners should be aware that investigators have reported successful analgesia using the following with long-acting local anesthetics: basal rate of 4 to 8 mL/h, bolus volume of 2 to 5 mL, and lockout duration of 20 to 60 minutes. Practitioners should be aware that the maximum safe doses for the long-acting local anesthetics remain unknown. However, multiple investigations involving patients free of renal or hepatic disease have reported blood concentrations within acceptable limits following up to 5 days of perineural infusion with similar dosing schedules.38,62–64 Extrapolating from data involving patients receiving epidural bupivacaine infusion, a maximum infusion rate of 0.5 mg/kg per hour of bupivacaine may be considered.38

Following ambulatory shoulder surgery with an interscalene catheter, infusion duration may be increased and similar baseline analgesia may be provided by decreasing the basal rate from 8 to 4 mL/h when patients supplement their block with large bolus doses (6 mL).33 However, patients experience an increase in breakthrough pain incidence and intensity, sleep disturbances, and a decrease in satisfaction with their analgesia. Therefore, if ambulatory patients do not return for additional local anesthetic, practitioners are left with the dilemma of superior analgesia for a shorter duration versus a lesser degree of analgesia for a longer period of time. Of note, the infusion duration may be increased by progressively decreasing the basal infusion rate with a reprogrammable infusion pump, thus theoretically maximizing postoperative analgesia.7

The publications that investigated the optimal dosing regimen for outpatients involved surgical procedures producing moderate postoperative pain. For procedures inducing mild postoperative pain, it is possible—even probable—that adequate analgesia would be adequately treated with a bolus-only dosing regimen.31 There is also the possibility that stimulating catheters may be placed, on average, closer to the target nerve/plexus compared with nonstimulating devices.49 If so, then the optimal dosing regimens, basal rates, and bolus doses may vary among different catheter types. Unfortunately, there are currently insufficient published data to draw any conclusions.


• There is no one perfect infusion pump for all applications.

• A multitude of factors must be taken into account when choosing a pump.

Multiple small portable infusion pumps are currently available (Table 7-1Figures 7-2 and 7-3), each with benefits and limitations (Table 7-2). Many factors must be taken into account when determining the optimal device for a given clinical situation. The provided list of infusion devices includes those for which performance data are available from independent sources and is not meant to be an exhaustive list of available units.


TABLE 7-1 Infusion Pump Distributors


FIGURE 7-2. Examples of portable disposable basal- and bolus-capable infusion pumps. (A) Pain Care 3200, (B) Pain Pump II, (C) On-Q C-Bloc with OnDemand, (D) Accufuser Plus XL, (E) ambIT PCA, (F) AutoMed 3200. Distributor information and pump attributes are included in the appendix and Table 7-2. Note that the ambIT PCA is produced as a disposable model as well as a more expensive reusable unit and therefore appears in both Figures 7-2and 7-3.


FIGURE 7-3. Examples of portable reusable basal- and bolus-capable infusion pumps. (A) 6060 MT, (B) Ipump PMS, (C) CADD-Legacy PCA, (D) ambIT PCA, (E) BlockIt, (F) AutoMed 3400. Distributor information and pump attributes are included in the appendix and Table 7-2. Note that the ambIT PCA is produced as a disposable model as well as a more expensive reusable unit, and therefore appears in both Figures 7-2 and 7-3.

TABLE 7-2 Infusion Pump Attributes



Bolus-Dose Capability

Various pumps allow for both patient-controlled local anesthetic boluses and a basal infusion (Table 7–2); others allow for only one of these.65–69 Bolus-dose capability (also termed patient-controlled regional analgesia, or PCRA) offers two significant benefits over continuous infusions alone. First, higher doses of oral opiates are often required for breakthrough pain without patient-controlled bolus doses.34,68Second, for outpatients using a limited local anesthetic reservoir, PCRA allows a provider to minimize the basal rate and, in turn, allows maximum infusion duration and minimal motor block7 yet also permits bolus dosing for breakthrough pain34 and physical therapy.27,33,36,70Compared with continuous infusions alone, equivalent or superior analgesia with a lower rate of local anesthetic consumption may be provided by using patient-controlled local anesthetic.34,59–61

Disposability and Cost

Reusable electronic infusion pumps are generally more expensive than the available single-use/disposable models (Table 7–2). However, reusable pumps that use relatively inexpensive disposable “cassettes” for each new patient (usually about US$10) may be more cost effective for practitioners who use these devices repeatedly (Table 7–2). But a reusable unit requires the patient to return the infusion pump by either the mail service or revisiting the surgical center.33,34,36

Patient Instructions

• A prescription for oral opioids should be filled by patients following discharge.

• Oral and written instructions, including health care provider contact numbers, should be provided.

Following a single-injection nerve block for ambulatory surgery, discharge with an insensate extremity results in minimal complications.71 However, whether or not patients should weight-bear with a continuous peripheral nerve block remains unexamined. Therefore, conservative management may be optimal, and some investigators have recommended that patients avoid using their surgical limb for weightbearing.8,16,36 A prescription for oral analgesics should be provided to all patients, and the importance of filling the prescription immediately after leaving the surgical center should be emphasized. If patients wait to fill the prescription until after they have determined if oral analgesics are required, a period of inadequate analgesia may result.

Most investigators educate both the patient and his or her caretaker at the same time before discharge because most patients have some degree of postoperative cognitive dysfunction. Both verbal and written instructions should be provided, along with contact numbers for health care providers who are available throughout the infusion duration.6,15,31,72 In addition to standard outpatient instructions, topics reviewed often include expectations regarding surgical block resolution, infusion pump instructions, breakthrough pain treatment, catheter site care, limb protection, and the plan for catheter removal. Forewarning that pain in the operative limb is anticipated following surgical block resolution and fluid leakage at the catheter site is common—and what to do if these are experienced—often proves helpful. Signs and symptoms of possible catheter- and local anesthetic-related complications include, but are not limited to, pulmonary compromise,40,41 nerve injury,73 site infection,74 and local anesthetic toxicity.53 Although there are case reports of initially misplaced catheters, migration following a documented correct placement has not been described but remains a theoretical risk.51–53,75,76 Possible complications of an unidentified initially misplaced catheter or of a catheter migration include intravascular or interpleural catheterization resulting in local anesthetic toxicity, intramuscular catheterization resulting in myonecrosis, and epidural/intrathecal catheterization when using interscalene, intersternocleidomastoid, paravertebral, or psoas compartment catheters. As is standard of care for inpatients, health care providers may want to consider documenting each patient contact (Figure 7-4).




FIGURE 7-4. An example of a progress note that may be used to record telephone contacts with ambulatory patients. Reproduced with permission.79

Catheter removal may be achieved with various techniques: Patients may be discharged with written instructions,12 a health care provider may perform this procedure,77 or patients’ caretakers (or occasionally the patients themselves) may remove the catheters with instructions given by a provider over the telephone.15–17,33,34,36 Although one technique has not been demonstrated to be superior to the others, one survey revealed that with instructions given by phone, 98% of patients felt comfortable removing their catheter at home.78 Of note, only 4% would have preferred to return for a health care provider to remove the catheter, and 43% responded they would have felt comfortable with exclusively written instructions.78 Nonsterile gloves may be provided for patients having their catheters removed at home.15–17


1. Rawal N, Hylander J, Nydahl PA, Olofsson I, Gupta A. Survey of postoperative analgesia following ambulatory surgery. Acta Anaesthesiol Scand. 1997;41:1017-1022.

2. Ansbro FP. A method of continuous brachial plexus block. Am J Surg. 1946;71:716-722.

3. Rawal N, Axelsson K, Hylander J, et al. Postoperative patient-controlled local anesthetic administration at home. Anesth Analg. 1998;86:86-89.

4. Buckenmaier CC III, Klein SM, Nielsen KC, Steele SM. Continuous paravertebral catheter and outpatient infusion for breast surgery. Anesth Analg. 2003;97:715-717.

5. Ganapathy S, Amendola A, Lichfield R, Fowler PJ, Ling E. Elastomeric pumps for ambulatory patient controlled regional analgesia. Can J Anaesth. 2000;47:897-902.

6. Macaire P, Gaertner E, Capdevila X. Continuous post-operative regional analgesia at home. Minerva Anesthesiol. 2001;67:109-116.

7. Ilfeld BM, Enneking FK. A portable mechanical pump providing over four days of patient-controlled analgesia by perineural infusion at home. Reg Anesth Pain Med. 2002;27:100-104.

8. Corda DM, Enneking FK. A unique approach to postoperative analgesia for ambulatory surgery. J Clin Anesth. 2000;12:595-599.

9. Grant SA, Nielsen KC, Greengrass RA, Steele SM, Klein SM. Continuous peripheral nerve block for ambulatory surgery. Reg Anesth Pain Med. 2001;26:209-214.

10. Klein SM, Greengrass RA, Grant SA, Higgins LD, Nielsen KC, Steele SM. Ambulatory surgery for multi-ligament knee reconstruction with continuous dual catheter peripheral nerve blockade. Can J Anaesth. 2001;48:375-378.

11. Chelly JE, Gebhard R, Coupe K, Greger J, Khan A. Local anesthetic delivered via a femoral catheter by patient-controlled analgesia pump for pain relief after an anterior cruciate ligament outpatient procedure. Am J Anesthesiol.2001;28:192-194.

12. Klein SM, Greengrass RA, Gleason DH, Nunley JA, Steele SM. Major ambulatory surgery with continuous regional anesthesia and a disposable infusion pump. Anesthesiology. 1999;91:563-565.

13. Ilfeld BM, Smith DW, Enneking FK. Continuous regional analgesia following ambulatory pediatric orthopedic surgery. Am J Orthop. 2004;33:405-408.

14. Klein SM, Grant SA, Greengrass RA, et al. Interscalene brachial plexus block with a continuous catheter insertion system and a disposable infusion pump. Anesth Analg. 2000;91:1473-1478.

15. Ilfeld BM, Morey TE, Enneking FK. Continuous infraclavicular brachial plexus block for postoperative pain control at home: a randomized, double-blinded, placebo-controlled study. Anesthesiology. 2002;96:1297-1304.

16. Ilfeld BM, Morey TE, Wang RD, Enneking FK. Continuous popliteal sciatic nerve block for postoperative pain control at home: a randomized, double-blinded, placebo-controlled study. Anesthesiology. 2002;97:959-965.

17. Ilfeld BM, Morey TE, Wright TW, Chidgey LK, Enneking FK. Continuous interscalene brachial plexus block for postoperative pain control at home: a randomized, double-blinded, placebo-controlled study. Anesth Analg.2003;96:1089-1095.

18. White PF, Issioui T, Skrivanek GD, Early JS, Wakefield C. The use of a continuous popliteal sciatic nerve block after surgery involving the foot and ankle: does it improve the quality of recovery? Anesth Analg. 2003;97:1303-1309.

19. Wu CL, Naqibuddin M, Rowlingson AJ, Lietman SA, Jermyn RM, Fleisher LA. The effect of pain on health-related quality of life in the immediate postoperative period. Anesth Analg. 2003;97:1078-1085.

20. Public health focus: surveillance, prevention, and control of nosocomial infections. MMWR CDC Surveill Summ. 1992;41:783-787.

21. Wenzel RP, Edmond MB. The impact of hospital-acquired bloodstream infections. Emerg Infect Dis. 2001;7:174-177.

22. Relman AS. The institute of medicine report on the quality of health care. N Engl J Med. 2001;345:702-703.

23. Leape LL. Institute of Medicine medical error figures are not exaggerated. JAMA. 2000;284:95-97.

24. Mushinski M. Average charges for hip replacement surgeries: United States, 1997. Stat Bull Metrop Insur Co. 1999;80:32-40.

25. Mushinski M. Average charges for a total knee replacement: United States, 1994. Stat Bull Metrop Insur Co. 1996;77:24-30.

26. Weinstein J. The Dartmouth Atlas of Musculoskeletal Health Care. Chicago, IL: AHA Press; 2000:72-78.

27. Ilfeld BM, Wright TW, Enneking FK, et al. Effect of interscalene perineural local anesthetic infusion on postoperative physical therapy following total shoulder replacement. Reg Anesth Pain Med.2004;29:A18.

28. Ilfeld BM, Gearen PF, Enneking FK, et al. Effect of femoral perineural local anesthetic infusion on postoperative functional ability following total knee arthroplasty. Anesthesiology. 2004;101:A945.

29. Ekatodramis G, Macaire P, Borgeat A. Prolonged Horner syndrome due to neck hematoma after continuous interscalene block. Anesthesiology. 2001;95:801-803.

30. Ribeiro FC, Georgousis H, Bertram R, Scheiber G. Plexus irritation caused by interscalene brachial plexus catheter for shoulder surgery. Anesth Analg. 1996;82:870-872.

31. Rawal N, Allvin R, Axelsson K, et al. Patient-controlled regional analgesia (PCRA) at home: controlled comparison between bupivacaine and ropivacaine brachial plexus analgesia. Anesthesiology. 2002;96:1290-1296.

32. Johnson T, Monk T, Rasmussen LS, et al. Postoperative cognitive dysfunction in middle-aged patients. Anesthesiology. 2002;96:1351-1357.

33. Ilfeld BM, Morey TE, Wright TW, Chidgey LK, Enneking FK. Interscalene perineural ropivacaine infusion: a comparison of two dosing regimens for postoperative analgesia. Reg Anesth Pain Med. 2004;29:9-16.

34. Ilfeld BM, Morey TE, Enneking FK. Infraclavicular perineural local anesthetic infusion: a comparison of three dosing regimens for postoperative analgesia. Anesthesiology. 2004;100:395-402.

35. Ilfeld BM, Morey TE, Enneking FK. Continuous infraclavicular perineural infusion with clonidine and ropivacaine compared with ropivacaine alone: a randomized, double-blinded, controlled study. Anesth Analg. 2003;97:706-712.

36. Ilfeld BM, Thannikary LJ, Morey TE, Vander Griend RA, Enneking FK. Popliteal sciatic perineural local anesthetic infusion: a comparison of three dosing regimens for postoperative analgesia. Anesthesiology. 2004;101:970-977.

37. Klein SM, Steele SM, Nielsen KC, et al. The difficulties of ambulatory interscalene and intra-articular infusions for rotator cuff surgery: a preliminary report. Can J Anaesth. 2003;50:265-269.

38. Denson DD, Raj PP, Saldahna F, et al. Continuous perineural infusion of bupivacaine for prolonged analgesia: pharmacokinetic considerations. Int J Clin Pharmacol Ther Toxicol. 1983;21:591-597.

39. Pere P. The effect of continuous interscalene brachial plexus block with 0.125% bupivacaine plus fentanyl on diaphragmatic motility and ventilatory function. Reg Anesth. 1993;18:93-97.

40. Smith MP, Tetzlaff JE, Brems JJ. Asymptomatic profound oxyhemoglobin desaturation following interscalene block in a geriatric patient. Reg Anesth Pain Med. 1998;23:210-213.

41. Sardesai AM, Chakrabarti AJ, Denny NM. Lower lobe collapse during continuous interscalene brachial plexus local anesthesia at home. Reg Anesth Pain Med. 2004;29:65-68.

42. Borgeat A, Perschak H, Bird P, Hodler J, Gerber C. Patient-controlled interscalene analgesia with ropivacaine 0.2% versus patient-controlled intravenous analgesia after major shoulder surgery: effects on diaphragmatic and respiratory function. Anesthesiology. 2000;92:102-108.

43. Salinas FV. Location, location, location: Continuous peripheral nerve blocks and stimulating catheters. Reg Anesth Pain Med. 2003;28:79-82.

44. Coleman MM, Chan VW. Continuous interscalene brachial plexus block. Can J Anaesth. 1999;46:209-214.

45. Ganapathy S, Wasserman RA, Watson JT, et al. Modified continuous femoral three-in-one block for postoperative pain after total knee arthroplasty. Anesth Analg. 1999;89:1197-1202.

46. Borgeat A, Dullenkopf A, Ekatodramis G, Nagy L. Evaluation of the lateral modified approach for continuous interscalene block after shoulder surgery. Anesthesiology. 2003;99:436-442.

47. Borgeat A, Blumenthal S, Karovic D, Delbos A, Vienne P. Clinical evaluation of a modified posterior anatomical approach to performing the popliteal block. Reg Anesth Pain Med. 2004;29:290-296.

48. Boezaart AP, de Beer JF, du Toit C, van Rooyen K. A new technique of continuous interscalene nerve block. Can J Anaesth. 1999;46:275-281.

49. Salinas FV, Neal JM, Sueda LA, Kopacz DJ, Liu SS. Prospective comparison of continuous femoral nerve block with nonstimulating catheter placement versus stimulating catheter-guided perineural placement in volunteers. Reg Anesth Pain Med. 2004;29:212-220.

50. Chelly JE, Williams BA. Continuous perineural infusions at home: narrowing the focus. Reg Anesth Pain Med. 2004;29:1-3.

51. Litz RJ, Vicent O, Wiessner D, Heller AR. Misplacement of a psoas compartment catheter in the subarachnoid space. Reg Anesth Pain Med. 2004;29:60-64.

52. Cook LB. Unsuspected extradural catheterization in an interscalene block. Br J Anaesth. 1991;67:473-475.

53. Tuominen MK, Pere P, Rosenberg PH. Unintentional arterial catheterization and bupivacaine toxicity associated with continuous interscalene brachial plexus block. Anesthesiology. 1991;75:356-358.

54. Casati A, Borghi B, Fanelli G, et al. Interscalene brachial plexus anesthesia and analgesia for open shoulder surgery: a randomized, double-blinded comparison between levobupivacaine and ropivacaine. Anesth Analg.2003;96:253-259.

55. Buettner J, Klose R, Hoppe U, Wresch P. Serum levels of mepivacaine-HCl during continuous axillary brachial plexus block. Reg Anesth. 1989;14:124-127.

56. Wajima Z, Shitara T, Nakajima Y, et al. Comparison of continuous brachial plexus infusion of butorphanol, mepivacaine and mepivacaine-butorphanol mixtures for postoperative analgesia. Br J Anaesth. 1995;75:548-551.

57. Bergman BD, Hebl JR, Kent J, Horlocker TT. Neurologic complications of 405 consecutive continuous axillary catheters. Anesth Analg. 2003;96:247-252.

58. Borgeat A, Kalberer F, Jacob H, Ruetsch YA, Gerber C. Patient-controlled interscalene analgesia with ropivacaine 0.2% versus bupivacaine 0.15% after major open shoulder surgery: the effects on hand motor function. Anesth Analg. 2001;92:218-223.

59. Singelyn FJ, Gouverneur JM: Extended “three-in-one” block after total knee arthroplasty: continuous versus patient-controlled techniques. Anesth Analg. 2000;91:176-180.

60. Singelyn FJ, Seguy S, Gouverneur JM. Interscalene brachial plexus analgesia after open shoulder surgery: continuous versus patient-controlled infusion. Anesth Analg. 1999;89:1216-1220.

61. Singelyn FJ, Vanderelst PE, Gouverneur JM: Extended femoral nerve sheath block after total hip arthroplasty: continuous versus patient-controlled techniques. Anesth Analg. 2001;92:455-459.

62. Ekatodramis G, Borgeat A, Huledal G, Jeppsson L, Westman L, Sjovall J. Continuous interscalene analgesia with ropivacaine 2 mg/ml after major shoulder surgery. Anesthesiology. 2003;98:143-150.

63. Kaloul I, Guay J, Cote C, Halwagi A, Varin F. Ropivacaine plasma concentrations are similar during continuous lumbar plexus blockade using the anterior three-in-one and the posterior psoas compartment techniques. Can J Anaesth. 2004;51:52-56.

64. Anker-Moller E, Spangsberg N, Dahl JB, Christensen EF, Schultz P, Carlsson P. Continuous blockade of the lumbar plexus after knee surgery: a comparison of the plasma concentrations and analgesic effect of bupivacaine 0.250% and 0.125%. Acta Anaesthesiol Scand. 1990;34:468-472.

65. Ilfeld BM, Morey TE, Enneking FK. The delivery rate accuracy of portable infusion pumps used for continuous regional analgesia. Anesth Analg. 2002;95:1331-1336.

66. Ilfeld BM, Morey TE, Enneking FK. Delivery rate accuracy of portable, bolus-capable infusion pumps used for patient-controlled continuous regional analgesia. Reg Anesth Pain Med. 2003;28:17-23.

67. Ilfeld BM, Morey TE, Enneking FK. Portable infusion pumps used for continuous regional analgesia: delivery rate accuracy and consistency. Reg Anesth Pain Med. 2003;28:424-432.

68. Ilfeld BM, Morey TE. Use of term “patient-controlled” may be confusing in study of elastometric pump. Anesth Analg. 2003;97:916-917.

69. Ilfeld BM, Morey TE, Enneking FK. New portable infusion pumps: real advantages or just more of the same in a different package? Reg Anesth Pain Med. 2004;29:371-376.

70. Ilfeld BM, Gearen PF, Enneking FK, et al. Effect of femoral perineural local anesthetic infusion on postoperative functional ability following total knee arthroplasty. Anesthesiology. 2004;101:A945.

71. Klein SM, Nielsen KC, Greengrass RA, Warner DS, Martin A, Steele SM. Ambulatory discharge after long-acting peripheral nerve blockade: 2382 blocks with ropivacaine. Anesth Analg. 2002;94:65-70.

72. Grant SA, Nielsen KC. Continuous peripheral nerve catheters for ambulatory anesthesia. Curr Anesthesiol Reports. 2000;2:304-307.

73. Borgeat A, Ekatodramis G, Kalberer F, Benz C. Acute and nonacute complications associated with interscalene block and shoulder surgery: a prospective study. Anesthesiology. 2001;95:875-880.

74. Cuvillon P, Ripart J, Lalourcey L, et al. The continuous femoral nerve block catheter for postoperative analgesia: bacterial colonization, infectious rate and adverse effects. Anesth Analg. 2001;93:1045-1049.

75. Souron V, Reiland Y, De Traverse A, Delaunay L, Lafosse L. Interpleural migration of an interscalene catheter. Anesth Analg. 2003;97:1200-1201.

76. Hogan Q, Dotson R, Erickson S, Kettler R, Hogan K. Local anesthetic myotoxicity: a case and review. Anesthesiology. 1994;80:942-947.

77. Chelly JE, Greger J, Gebhard R. Ambulatory continuous perineural infusion: are we ready? [letter]. Anesthesiology. 2000;93:581-582.

78. Ilfeld BM, Esener DE, Morey TE, Enneking FK. Ambulatory perineural infusion: the patients’ perspective. Reg Anesth Pain Med. 2003;28:418-423.

79. Ilfeld BM, Enneking FK. Continuous nerve blocks at home: a review. Anesth Analg. 2005;100:1822–1833.

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