Part 1 - The Normal Thyroid
SECTION 1. History, Development, Anatomy
Chapter 1.The Heritage of the Thyroid: A Brief History
Chapter 2.Development and Anatomy of the Hypothalamic–Pituitary–Thyroid Axis
Chapter 3.Anatomy and Pathology of the Thyrotrophs
SECTION 2. Thyroid Synthesis and Secretion
Chapter 4A. Thyroid Iodine Transport
Chapter 4B.Thyroid Hormone Synthesis
Chapter 5.Thyroglobulin Structure, Function, and Biosynthesis
SECTION 3. Peripheral Hormone Metabolism
Chapter 6.Thyroid Hormone Transport Proteins and the Physiology of Hormone Binding
Chapter 7.Intracellular Pathways of Iodothyronine Metabolism
SECTION 4. Thyroid Hormone Action
Chapter 8.Genomic and Nongenomic Actions of Thyroid Hormones
Chapter 9.Thyroid Hormone Structure–Function Relationships
SECTION 5. Factors That Control Thyroid Function
Chapter 10A.Chemistry and Biosynthesis of Thyrotropin
Chapter 10B.The Thyrotropin Receptor
Chapter 10C.Biological Actions of Thyrotropin
Chapter 10D.Regulation of Thyrotropin Secretion
Chapter 11A.Age-Related Changes in Thyroid Secretion
Chapter 11B.Environmental Influences Upon Thyroid Hormone Regulation
Chapter 11C.Effects of Drugs and Other Substances on Thyroid Hormone Synthesis and Metabolism
Chapter 11D.Nonthyroidal Illness
Chapter 11F.Effect of Excess Iodide: Clinical Aspects
Part 2 - Laboratory Assessment of Thyroid Function
Chapter 12.In vivo Radionuclide Tests and Imaging
Chapter 13.Measuring Serum Thyrotropin and Thyroid Hormone and Assessing Thyroid Hormone Transport
Chapter 15.Thyroid-Directed Antibodies
Chapter 16.Nonisotopic Techniques of Thyroid Imaging
Part 3 - Introduction to Thyroid Diseases
Chapter 18.Physical Examination of the Thyroid Gland
Chapter 19.The Epidemiology of Thyroid Diseases
Chapter 20.Genetic Factors in Thyroid Disease
Part 4 - Thyroid Diseases: Thyrotoxicosis
SECTION 1. Introduction
Chapter 22.Introduction to Thyrotoxicosis
SECTION 2. Causes of Hyperthyroidism
Chapter 23A.The Pathogenesis of Graves' Disease
Chapter 23C.Localized Myxedema and Thyroid Acropachy
Chapter 24.Thyrotropin-Induced Thyrotoxicosis
Chapter 25.Toxic Adenoma and Toxic Multinodular Goiter
Chapter 26.Trophoblastic Tumors
Chapter 27.Sporadic and Postpartum Thyroiditis
Chapter 28.Subacute Thyroiditis and Acute Infectious Thyroiditis
Chapter 29.Thyrotoxicosis of Extrathyroid Origin
SECTION 3. Organ System Manifestations
Chapter 30.The Skin in Thyrotoxicosis
Chapter 31.The Cardiovascular System in Thyrotoxicosis
Chapter 32.The Pulmonary System in Thyrotoxicosis
Chapter 33.The Kidneys and Electrolyte Metabolism in Thyrotoxicosis
Chapter 34.The Gastrointestinal Tract and Liver in Thyrotoxicosis
Chapter 35.The Blood in Thyrotoxicosis
Chapter 36.The Pituitary in Thyrotoxicosis
Chapter 37.The Adrenal Cortex in Thyrotoxicosis
Chapter 38.Thermogenesis and the Sympathoadrenal System in Thyrotoxicosis
Chapter 39.The Male and Female Reproductive System in Thyrotoxicosis
Chapter 40.The Skeletal System in Thyrotoxicosis
Chapter 41.The Neuromuscular System and Brain in Thyrotoxicosis
Chapter 42.Behavioral and Psychiatric Aspects of Thyrotoxicosis
Chapter 44.Diagnosis of Thyrotoxicosis
Chapter 45.Treatment of Thyrotoxicosis
Part 5 - Thyroid Diseases: Hypothyroidism
SECTION 1. Introduction
Chapter 46.Introduction to Hypothyroidism
SECTION 2. Causes of Hypothyroidism
Chapter 47.Chronic Autoimmune Thyroiditis
Chapter 48.Genetic Defects Causing Hypothyroidism
Chapter 50.Primary Hypothyroidism Due to Other Causes
Chapter 51.Central Hypothyroidism
SECTION 2. Organ System Manifestations of Hypothyroidism
Chapter 52.The Skin and Connective Tissue in Hypothyroidism
Chapter 53.The Cardiovascular System in Hypothyroidism
Chapter 54.The Pulmonary System in Hypothyroidism
Chapter 55.The Kidneys and Electrolyte Metabolism in Hypothyroidism
Chapter 56.The Gastrointestinal Tract and Liver in Hypothyroidism
Chapter 57.The Blood in Hypothyroidism
Chapter 58.The Pituitary in Hypothyroidism
Chapter 59.The Adrenal Cortex in Hypothyroidism
Chapter 60.Intermediary Metabolism and the Sympathoadrenal System in Hypothyroidism
Chapter 61.The Male and Female Reproductive System in Hypothyroidism
Chapter 62.The Skeletal System in Hypothyroidism
Chapter 63.The Neuromuscular System and Brain in Hypothyroidism
Chapter 64.Behavioral and Psychiatric Aspects of Hypothyroidism
SECTION 3. Management of Hypothyroidism
Chapter 66.Diagnosis of Hypothyroidism
Chapter 67.Treatment of Hypothyroidism
Part 6 - Thyroid Diseases: Nontoxic Diffuse and Multinodular Goiter
Chapter 68.Pathogenesis of Nontoxic Diffuse and Nodular Goiter
Chapter 69.Clinical Manifestations and Treatment of Nontoxic Diffuse and Nodular Goiter
Part 7 - Thyroid Diseases: Tumors
Chapter 70A.Epidemiology and Pathogenesis
Chapter 70B.Molecular Genetics of Tumors of Thyroid Follicular Cells
Chapter 70C.Carcinoma of Follicular Epithelium: Surgical Therapy
Chapter 70D.Carcinoma of Follicular Epithelium: Radioiodine and Other Treatments and Outcomes
Chapter 71. Medullary Thyroid Carcinoma
Chapter 72. Miscellaneous Tumors of the Thyroid
Chapter 73. Clinical Evaluation and Management of Solitary Thyroid Nodules
Part 8 - The Thyroid in Infancy and Childhood
Chapter 74. The Maturation of Thyroid Function in the Perinatal Period and During Childhood
Chapter 75A. Hypothyroidism in Infants and Children: Neonatal Screening
Chapter 75B. Hypothyroidism in Infants and Children: Congenital Hypothyroidism
Chapter 75C. Hypothyroidism in Infants, Children, and Adolescents: Acquired Hypothyroidism
Chapter 76. Graves' Disease in the Neonatal Period and Childhood
Part 9 - Special Topics in Thyroidology
Chapter 77. Morbidity and Mortality in Thyroid Dysfunction and its Treatment
Chapter 78. Subclinical Hypothyroidism
Chapter 79. Subclinical Thyrotoxicosis
Chapter 80. Thyroid Disease During Pregnancy
Chapter 81. Resistance to Thyroid Hormone