Laboratory Diagnosis in Neurology, 1 Ed.

5 Cerebrospinal Fluid Analysis

B. Storch-Hagenlocher, H Reiber, B. Wildemann, M. Otto

The technical invention that would allow lumbar puncture to become an established procedure for diagnostic and therapeutic purposes came about when, in 1853, Alexander Wood invented the hollow needle and the glass syringe. In 1872, Heinrich I. Quincke (1842–1922) published two articles, “Transkutane Lumbalpunktion zwischen dem 3. und 4. Lendenwirbelkörper” (“Trancutaneous lumbar puncture between the third and fourth lumbar vertebrae”) and “Ergebnisse über Zellanteil, Gesamteiweiß, Tuberkelbakterien und Zuckergehalt” (“Results relating to cell fraction, total albumin, tuberculosis bacteria, and sugar content”), thus providing the foundation of modern CSF analysis as a routine diagnostic procedure.

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