Cancer Chemotherapy & Biotherapy: Principles & Practices, 4th Edition


Color Figures


Figure 18.4 Anthracycline antibiotic cell death program. Anthracycline antibiotics can be metabolized at the cell surface, at complex I of the mitochondrial electron transport chain, in the cytosol, or at the nuclear envelop by flavin-containing dehydrogenases, leading to the production of reactive oxygen species with the potential to alter intracellular iron stores at multiple intracellular sites. This free-radical cascade can initiate both apoptotic and necrotic death programs associated with mitochondrial membrane injury, DNA base oxidation, altered calcium sequestration, energy loss, and altered proliferative potential. The effects of anthracycline-enhanced reactive oxygen production are modulated by intracellular antioxidant enzymes (glutathione peroxidase, catalase) and anti-apoptotic proteins. Mt, mitochondrial. (see black and white image)


Figure 31.2 Space-filling model of human immunoglobulin G1 antibody with complementarity-determining regions in color representing anti–Tac-H; human myeloma protein Eu with complementarity-determining regions grafted from murine anti-Tac. (Photo provided courtesy of Dr. C. Queen.) (see black and white image)


Figure 31.3 Antigen-antibody binding surface juxtaposition. The variable (V) region (Fv) of antibody (right) binds to influenza virus protein neuraminidase (left) in the top panel. The VH (red) and VL (blue) regions are separately colored to show their respective binding contributions. The bottom panel offsets the two molecules by 8 Å to show the complementarity of surfaces that promotes the binding interaction. The stippled surface of the neuraminidase defines the antigen “epitope.” (Photo provided courtesy of Drs. P.M. Colman and W.R. Tulip, CSIRO Australia.) (see black and white image)