Manual of Clinical Oncology (Lippincott Manual), 7 Ed.

Appendix B

National Cancer Institutes Common Toxicity Criteria for Adverse Events (CTCAE), Abridged

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aNote: Grade 5 is death.

ADL, activities of daily living are limited; ADL-I, ADL-instrumental (preparing meals, shopping, using telephone, managing money, etc.);

ADL-SC, ADL-self-care (bathing, dressing, feeding self, using the toilet, taking medications, and not bedridden); AE, adverse events; INI, intervention not indicated; LLN, lower limit of normal; LTC, life-threatening consequences; MII, medical intervention indicated; UII, urgent intervention indicated; ULN, upper limit of normal.

Site-specific abbreviations: BSA, body surface area; DTRs, deep tendon reflexes; ECG QTc, electrocardiogram QT (corrected) interval; eGFR, estimated glomerular filtration rate; CrCl, creatinine clearance; INR, international normalized ratio for prothrombin time; IV, intravenous; LVEF, left ventricular ejection fraction; PTT, partial thromboplastin time; TPN, total parenteral nutrition; TTP/HUS, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome

Extracted from the National Cancer Institute. Common Terminology Criteria for Adverse Events, v. 4.03. Published: June 14, 2010. The entire 80-page document defining Adverse Events can be downloaded from http://ctep.cancer.gov/reporting/ctc.html



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