aNote: Grade 5 is death.
ADL, activities of daily living are limited; ADL-I, ADL-instrumental (preparing meals, shopping, using telephone, managing money, etc.);
ADL-SC, ADL-self-care (bathing, dressing, feeding self, using the toilet, taking medications, and not bedridden); AE, adverse events; INI, intervention not indicated; LLN, lower limit of normal; LTC, life-threatening consequences; MII, medical intervention indicated; UII, urgent intervention indicated; ULN, upper limit of normal.
Site-specific abbreviations: BSA, body surface area; DTRs, deep tendon reflexes; ECG QTc, electrocardiogram QT (corrected) interval; eGFR, estimated glomerular filtration rate; CrCl, creatinine clearance; INR, international normalized ratio for prothrombin time; IV, intravenous; LVEF, left ventricular ejection fraction; PTT, partial thromboplastin time; TPN, total parenteral nutrition; TTP/HUS, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome
Extracted from the National Cancer Institute. Common Terminology Criteria for Adverse Events, v. 4.03. Published: June 14, 2010. The entire 80-page document defining Adverse Events can be downloaded from http://ctep.cancer.gov/reporting/ctc.html