Manual of Clinical Oncology (Lippincott Manual), 7 Ed.

Appendix D

Chemotherapy Regimens for Lymphomas

Appendix D1 Regimens for Hodgkin Lymphoma (HL)

Appendix D2 Regimens for Non-Hodgkin Lymphoma (NHL)

Appendix D3 Salvage Regimens for Hodgkin and Non-Hodgkin Lymphoma

Appendix D1 Regimens for Hodgkin Lymphoma (HL)^a

Bleo, bleomycin (dose in units/m²); Chl, chlorambucil; Cyclo, cyclophosphamide; Dexa, dexamethasone; Doxo, doxorubicin (Adriamycin); DTIC, dacarbazine; Etop, etoposide; Max, maximum dose; Mechl, mechlorethamine (nitrogen mustard); Pcz, procarbazine; Prednis, prednisolone; Vbl, vinblastine; Vcr, vincristine; Vin, vinorelbine

^aDrugs and dosage in mg/m² (days given in cycle). All doses are given intravenously (IV) except when they are oral (PO), where indicated.

^bMaximum, 2.0-mg dose

Appendix D2 Regimens for Non-Hodgkin Lymphoma (NHL)^a

ANC, absolute neutrophil count per μL; Bleo, Bleomycin; Chl, chlorambucil; Cyclo, cyclophosphamide; Cytar, cytarabine; over 1h; Dexa, dexamethasone; Doxo, doxorubicin (Adriamycin); Etop, etoposide; Flud, fludarabine; GCSF, granulocyte colony-stimulating factor (5 mcg/kg SQ or IV daily); Ifos, ifosfamide; Leuc, leucovorin; Mtx, methotrexate; Pred, prednisone; Ritux, rituximab; Vcr, vincristine; WBC, white blood cell count per μL

^a Drugs and dosage in mg/m² (days given in cycle). All doses are given intravenously (IV) except when they are oral (PO) or intrathecal (IT), where indicated. Rituximab, 375 mg/m² weekly for 4 weeks, is frequently added to these regimens for CD20-positive NHLs

^bMaximum, 2.0-mg dose

^cTotal dose (not per m²)

^dLeucovorin begins at 24 h after Mtx is started

^eAntimicrobials PO daily for 12 weeks: cotrimoxazole 2 b.i.d. and ketoconazole 200 mg q d

^fLeucovorin 192 mg/m² given at 36 h after Mtx started and then 12 mg/m² q6h until serum Mtx level <10^-8 M

^gReduce cytarabine dosage to 1,000 mg/m² per dose for patients older than 60 years or with serum creatinine levels higher than 1.5 mg/dL

^hLeucovorin 50 mg PO given 24 h after Mtx is finished then 15 mg q6h × 8 doses (adjusted according to serum Mtx level)

Appendix D3 Salvage Regimens for Hodgkin and Non-Hodgkin Lymphoma^a

AIDS, acquired immunodeficiency syndrome; ANC, absolute neutrophil count per μL; AUC, area under the curve using Calvert formula; b.i.d., twice daily PO; Bleo, bleomycin (dose in units/m²); Cis, cisplatin; CIV, by 24-h continuous intravenous infusion; Gem, gemcitabine; Lipos, liposomal;Vin, vinorelbine. Cyclo, cyclophosphamide; Doxo, doxorubicin; Etop, etoposide; GCSF, granulocyte colony-stimulating factor; (filgrastim); Ifos, ifosfamide; Nov, Novantrone (mitoxantrone); Ox, oxaliplatin; Vbl, vinblastine; Vcr, vincristine

^aDrugs and dosage in mg/m² (days given in cycle). All doses are intravenous (IV) bolus except when they are oral (PO) or CIV, where indicated. Rituximab, 375 mg/m² IV, is frequently added to these regimens

^bTotal dose (not per m²)