Rudolph's Pediatrics, 22nd Ed.

SECTION 1 Fundamentals of Pediatrics

CHAPTER 1. Role of the Pediatrician

CHAPTER 2. Decision Making: Use of Evidence-Based Medicine

CHAPTER 3. Communication

CHAPTER 4. Interviewing Techniques

CHAPTER 5. Systems of Practice and Office Management

CHAPTER 6. Core Competencies

CHAPTER 7. Patient and Family-Centered Care

CHAPTER 8. Disaster Preparedness

CHAPTER 9. Law, Ethics, and Clinical Judgment

SECTION 2 Health Promotion and Disease Prevention

CHAPTER 10. Well-Child Care

CHAPTER 11. Child Development

CHAPTER 12. Screening

CHAPTER 13. Oral Health Supervision

CHAPTER 14. Complementary and Alternative Medicine (CAM)

CHAPTER 15. Culture and Pediatric Practice

CHAPTER 16. Gay and Lesbian Parents

CHAPTER 17. Environmental Pediatrics

CHAPTER 18. Travel Medicine

CHAPTER 19. Family Function and Birth of a Child

CHAPTER 20. Foster Care and Adoption

CHAPTER 21. Family Discord and Divorce

CHAPTER 22. Supporting the Grieving Child and Family

SECTION 3 Nutrition

CHAPTER 23. Normal Nutritional Requirements

CHAPTER 24. Breast-Feeding

CHAPTER 25. Infant Formula and Complementary Foods

CHAPTER 26. Postdischarge Nutritional Management of the Premature Infant

CHAPTER 27. Nutritional Issues: Toddler to Adolescent

CHAPTER 28. Assessment of Nutritional Adequacy

CHAPTER 29. Malnutrition and Refeeding

CHAPTER 30. Poor Weight Gain

CHAPTER 31. Approach to the Infant and Child with Feeding Difficulty

CHAPTER 32. The Overweight or Obese Child

CHAPTER 33. Specialized Nutrition Support

CHAPTER 34. Nutritional Access Devices

SECTION 4 Abuse, Neglect, Violence

CHAPTER 35. Child Maltreatment: Neglect to Abuse

CHAPTER 36. Family and Community Violence

CHAPTER 37. Child Abuse Prevention: What Pediatricians Can Do

SECTION 5 Newborn

CHAPTER 38. Historical Perspectives

CHAPTER 39. Care of the Fetus

CHAPTER 40. Fetal Disorders

CHAPTER 41. Neonatal Mortality and Morbidity

CHAPTER 42. Delivery Room Resuscitation

CHAPTER 43. Transitional Changes in the Newborn

CHAPTER 44. Examination of the Newborn Infant

CHAPTER 45. Postnatal Care and Observation

CHAPTER 46. Multiple Births

CHAPTER 47. The Small-for-Gestational-Age Infant

CHAPTER 48. Infant of a Diabetic Mother

CHAPTER 49. Approach to the Cyanotic Infant

CHAPTER 50. Abnormalities of the Lungs

CHAPTER 51. Metabolic Abnormalities

CHAPTER 52. Brain Abnormalities and Injuries

CHAPTER 53. Hematologic Abnormalities and Jaundice

CHAPTER 54. Respiratory Distress Syndrome

CHAPTER 55. Patent Ductus Arteriosus and Ductus Venosus

CHAPTER 56. Hemodynamics

CHAPTER 57. Necrotizing Enterocolitis

CHAPTER 58. Intraventricular Hemorrhage

CHAPTER 59. Bronchopulmonary Dysplasia

CHAPTER 60. Emergencies

CHAPTER 61. Special Intensive Care

CHAPTER 62. Outcomes of Preterm and Term Infants

SECTION 6 Principles of Adolescent Care

CHAPTER 63. Somatic Growth and Development

CHAPTER 64. Reproductive Growth and Development in the Female Adolescent

CHAPTER 65. Reproductive Growth and Development in the Male Adolescent

CHAPTER 66. Psychological Development

CHAPTER 67. The Adolescent Visit

CHAPTER 68. Mortality

CHAPTER 69. Morbidity

CHAPTER 70. Sexual Behavior

CHAPTER 71. Substance Use and Abuse

CHAPTER 72. Depression, Anxiety, and Other Disorders

CHAPTER 73. Disorders of Eating

CHAPTER 74. Breast Masses

CHAPTER 75. Scrotal Masses

CHAPTER 76. Menstrual Problems

CHAPTER 77. Intrauterine and Ectopic Pregnancy

CHAPTER 78. Contraception

SECTION 7 Developmental and Behavioral Pediatrics

CHAPTER 79. Introduction to Developmental and Behavioral Pediatrics

CHAPTER 80. Fundamental Concepts of Child Development

CHAPTER 81. Brain Development and Behavior

CHAPTER 82. Standardized Developmental Screening and Assessment Instruments

CHAPTER 83. Crying in Infants

CHAPTER 84. Hyperactivity and Inattention

CHAPTER 85. Learning Problems

CHAPTER 86. Language Delay

CHAPTER 87. Difficult Behavior

CHAPTER 88. Anxiety

CHAPTER 89. Repetitive Behaviors

CHAPTER 90. Gender Identity and Sexual Behavior

CHAPTER 91. Developmental Delay

CHAPTER 92. Autistic Spectrum Disorders

CHAPTER 93. Affective Disorders and Suicide

CHAPTER 94. Pediatric Condition Falsification

CHAPTER 95. Childhood Schizophrenia

CHAPTER 96. Families in the 21st Century: An Introduction to Families

CHAPTER 97. Nonparental Childcare

CHAPTER 98. Vulnerable Child Syndrome

CHAPTER 99. Adaptation to Illness

CHAPTER 100. Poverty, Homelessness, and Social Disorganization

CHAPTER 101. Resiliency in Children and Adolescents

SECTION 8 The Acutely Ill Infant and Child

CHAPTER 102. Respiratory Distress and Failure

CHAPTER 103. Decreased Perfusion and Circulatory Shock

CHAPTER 104. Acute Neurological Dysfunction

CHAPTER 105. The Febrile Child

CHAPTER 106. Monitoring of Vital Function

CHAPTER 107. Vascular Access

CHAPTER 108. Cardiopulmonary Resuscitation

CHAPTER 109. Life Support Systems

CHAPTER 110. Stabilization and Transport

CHAPTER 111. Management of Cerebral Edema and Elevated Intracranial Pressure

CHAPTER 112. Perioperative Care

CHAPTER 113. Pain Management and Sedation

CHAPTER 114. Acute Metabolic Dysfunction

CHAPTER 115. Acute Inflammation

CHAPTER 116. Trauma, Burns, and Bites

CHAPTER 117. Submersion Injury

CHAPTER 118. Foreign-Body Aspiration

CHAPTER 119. Apparent Life-Threatening Events and SIDS

CHAPTER 120. Toxic Ingestions and Exposures

CHAPTER 121. Heat Stress

CHAPTER 122. Poisonous Bites and Stings

SECTION 9 The Chronically Ill Infant and Child

CHAPTER 123. Psychological and Behavioral Responses

CHAPTER 124. The Technology-Dependent Child

CHAPTER 125. Caring for Children Dying from Chronic Disease

CHAPTER 126. Hospice and Palliative Care

CHAPTER 127. Law, Ethics, and Caring Near the End of Life

SECTION 10 Transplantation

CHAPTER 128. Pediatric Transplantation

CHAPTER 129. Kidney Transplantation

CHAPTER 130. Liver Transplantation

CHAPTER 131. Intestinal and Multivisceral Transplant

CHAPTER 132. Heart Transplant

CHAPTER 133. Hematopoietic Cell Transplantation

SECTION 11 Inherited Disorders of Metabolism

CHAPTER 134. Principles of Inborn Errors of Metabolism

CHAPTER 135. Hyperphenylalaninemias

CHAPTER 136. Disorders of Tyrosine Metabolism

CHAPTER 137. Disorders of Branched Chain Amino and Organic Acid Metabolism

CHAPTER 138. Disorders of Sulfur-Containing Amino Acid Metabolism

CHAPTER 139. Disorders of Glycine, Serine, and Proline Metabolism

CHAPTER 140. Disorders of Metabolism of Lysine, Hydroxylysine, and Related Compounds

CHAPTER 141. Disorders of Metabolism of Neurotransmitter Amino Acids

CHAPTER 142. Disorders of Creatine and Ornithine Metabolism

CHAPTER 143. Disorders of Amino Acid Transport Across Cell Membranes

CHAPTER 144. Other Disorders of Amino Acid Metabolism

CHAPTER 145. Urea Cycle and Related Disorders

CHAPTER 146. Introduction

CHAPTER 147. Vitamin B12 and Folic Acid

CHAPTER 148. Biotin Responsive Disorders

CHAPTER 149. Vitamin B6 and Vitamin B1 Responsive Disorders

CHAPTER 150. Disorders of Fatty Acid Oxidation

CHAPTER 151. Disorders of Ketogenesis

CHAPTER 152. Disorders of Ketolysis

CHAPTER 153. Disorders of Leukotriene Synthesis and Fatty Aldehyde Dehydrogenase

PART 5. Carbohydrate Metabolism

CHAPTER 154. Disorders of Glycogen Metabolism

CHAPTER 155. Disorders of Galactose and Fructose Metabolism and Gluconeogenesis

CHAPTER 156. Disorders of Pentose Phosphate Pathway

CHAPTER 157. Disorders of Glucose Transporters

CHAPTER 158. Respiratory Chain Disorders

CHAPTER 159. Disorders of Energy Metabolism

CHAPTER 160. Mucopolysaccharidosis, Glycoproteinosis, and Mucolipidosis

CHAPTER 161. Sphingolipidoses

CHAPTER 162. Peroxisomal Disorders

CHAPTER 163. Congenital Disorders of Glycosylation

CHAPTER 164. Disorders of Cholesterol Synthesis

CHAPTER 165. Disorders of Bile Acid Synthesis

CHAPTER 166. Disorders of Lipid and Lipoprotein Metabolism

CHAPTER 167. Disorders of Heme Biosynthesis: The Porphyrias

CHAPTER 168. Disorders of Purine and Pyrimidine Metabolism

CHAPTER 169. Disorders of Metal Metabolism

SECTION 12 Clinical Genetics and Dysmorphology

CHAPTER 170. Key Principles in Human Genetics

CHAPTER 171. Multifactorial Inheritance

CHAPTER 172. Principles of Care

CHAPTER 173. Human Cytogenetics

CHAPTER 174. Chromosome Disorders

CHAPTER 175. Birth Defects, Malformations, and Syndromes

CHAPTER 176. Syndromes of Multiple Congenital Anomalies/Dysplasias

CHAPTER 177. Craniofacial Disorders

CHAPTER 178. Approach to the Child with Birth Defects

CHAPTER 179. Genetic Skeletal Disorders

CHAPTER 180. Congenital Contractures

CHAPTER 181. Connective Tissue Dysplasias

CHAPTER 182. Neurocutaneous Disorders

CHAPTER 183. Environmental Causes of Birth Defects

CHAPTER 184. Disorders of Accelerated Aging

CHAPTER 185. Genetic Evaluation of Developmental Delay/Mental Retardation

SECTION 13 Immunologic Disorders

CHAPTER 186. Overview of the Immune System

CHAPTER 187. Undue Susceptibility to Infection

CHAPTER 188. Primary Immunodeficiencies

CHAPTER 189. Complement Disorders

SECTION 14 Allergic Disorders

CHAPTER 190. Allergic Disease and Atopy

CHAPTER 191. Clinical Aspects of Allergic Diseases

CHAPTER 192. Allergic Rhinitis and Conjunctivitis

CHAPTER 193. Anaphylaxis, Urticaria, and Angioedema

CHAPTER 194. Food Allergy

CHAPTER 195. Insect Allergy

CHAPTER 196. Latex Allergy

SECTION 15 Rheumatology

CHAPTER 197. Adverse Reactions to Drugs

CHAPTER 198. Pathogenesis of Inflammatory and Autoimmune Disorders

CHAPTER 199. History and Physical Examination in Rheumatology

CHAPTER 200. Diagnostic Testing in Rheumatology

CHAPTER 201. Juvenile Idiopathic Arthritis

CHAPTER 202. Spondyloarthropathies

CHAPTER 203. Vasculitides

CHAPTER 204. Systemic Lupus Erythematosus, Overlap Connective Tissue Diseases, and Mixed Connective Tissue Disease

CHAPTER 205. Juvenile Dermatomyositis

CHAPTER 206. Scleroderma

CHAPTER 207. Musculoskeletal Pain Syndromes

CHAPTER 208. Chronic Fatigue Syndrome

CHAPTER 209. Autoinflammatory Disorders

SECTION 16 The Musculoskeletal System

CHAPTER 210. Growth and Development

CHAPTER 211. The Limping Child

CHAPTER 212. Torsional and Angular Deformities

CHAPTER 213. Disorders of the Foot

CHAPTER 214. Disorders of the Knee

CHAPTER 215. Developmental Dysplasia of the Hip

CHAPTER 216. Disorders of the Neck and Spine

CHAPTER 217. Disorders of the Upper Extremity

CHAPTER 218. Injuries

CHAPTER 219. Tumors

CHAPTER 220. Neuromuscular Disorders

CHAPTER 221. Common Orthopedic Misses

SECTION 17 Infectious Diseases

CHAPTER 222. Bacterial Pathogenesis

CHAPTER 223. Bacteremia, Sepsis, and Septic Shock

CHAPTER 224. Viral Pathogenesis

CHAPTER 225. Infection Control

CHAPTER 226. Diagnostic Approaches for Infectious Diseases

CHAPTER 227. Acute Fever without a Focus

CHAPTER 228. Fever of Unknown Origin

CHAPTER 229. Fever and Infection in the Immunocompromised Patient

CHAPTER 230. Therapy for Perinatal and Neonatal Infections

CHAPTER 231. Bacterial Infections of the Central Nervous System

CHAPTER 232. Viral Infections of the Central Nervous System

CHAPTER 233. Sexually Transmitted Infections

CHAPTER 234. Bone, Joint, Soft Tissue Infections

CHAPTER 235. Cardiac Infections

CHAPTER 236. Gastrointestinal Infections

CHAPTER 237. Infections of the Liver

CHAPTER 238. Urinary Tract Infections

CHAPTER 239. Catheter-Associated Infections

CHAPTER 240. Community-Acquired and Bacterial Pneumonia in Children

CHAPTER 241. Viral Respiratory Infections Including Influenza

CHAPTER 242. Fungal Respiratory Infections

CHAPTER 243. Infections of the Ear

CHAPTER 244. Immunizations

CHAPTER 245. Antiviral Therapy

CHAPTER 246. Antibacterial Therapy

CHAPTER 247. Antifungal Therapy

CHAPTER 248. Actinomycosis

CHAPTER 249. Anaerobic Bacterial Infections

CHAPTER 250. Clostridial Infections

CHAPTER 251. Anthrax (Bacillus anthracis)

CHAPTER 252. Arcanobacterium

CHAPTER 253. Bacillus cereus

CHAPTER 254. Brucellosis

CHAPTER 255. Burkholderia and Pseudomonas

CHAPTER 256. Campylobacter

CHAPTER 257. Cat Scratch Disease (Bartonella henselae)

CHAPTER 258. Chancroid (Hemophilus ducreyi)

CHAPTER 259. Chlamydia

CHAPTER 260. Cholera

CHAPTER 261. Diphtheria

CHAPTER 262. Enterococcus

CHAPTER 263. Haemophilus influenzae

CHAPTER 264. Legionella Pneumonia

CHAPTER 265. Leptospirosis

CHAPTER 266. Listeriosis

CHAPTER 267. Lyme Disease

CHAPTER 268. Moraxella catarrhalis

CHAPTER 269. Tuberculosis (Mycobacteria tuberculosis)

CHAPTER 270. Nontuberculous Mycobacterial Infections

CHAPTER 271. Leprosy

CHAPTER 272. Buruli Ulcer (Mycobacterium ulcerans Infection)

CHAPTER 273. Mycoplasma Infections

CHAPTER 274. Neisseria gonorrhoeae

CHAPTER 275. Neisseria meningitidis

CHAPTER 276. Nocardiosis

CHAPTER 277. Pasteurella multocida

CHAPTER 278. Pertussis

CHAPTER 279. Plague

CHAPTER 280. Pneumococcal Infections

CHAPTER 281. Rat-Bite Fever

CHAPTER 282. Relapsing Fever

CHAPTER 283. Salmonella, Shigella, and Escherichia coli

CHAPTER 284. Staphylococcus Infections

CHAPTER 285. Streptococcus Group A Infections

CHAPTER 286. Group B Streptococcus Infections

CHAPTER 287. Nongroup A or B Streptococcus

CHAPTER 288. Syphilis

CHAPTER 289. Tetanus

CHAPTER 290. Q Fever

CHAPTER 291. Tularemia

CHAPTER 292. Ureaplasma urealyticum Infections

CHAPTER 293. Yersinia enterocolitica Infections

CHAPTER 294. Rickettsial Infections

CHAPTER 295. Aspergillosis

CHAPTER 296. Blastomycosis

CHAPTER 297. Candida

CHAPTER 298. Coccidioidomycosis

CHAPTER 299. Cryptococcosis

CHAPTER 300. Histoplasmosis

CHAPTER 301. Malassezia furfur

CHAPTER 302. Microsporidiosis

CHAPTER 303. Sporotrichosis

CHAPTER 304. Zygomycosis (Mucormycosis)

CHAPTER 305. Arboviruses

CHAPTER 306. Enterovirus Infections

CHAPTER 307. Hemorrhagic Fevers

CHAPTER 308. Viral Hepatitis

CHAPTER 309. Herpes Simplex Virus Infections

CHAPTER 310. Cytomegalovirus

CHAPTER 311. Epstein-Barr Virus Mononucleosis

CHAPTER 312. Human Herpesviruses 6 and 7

CHAPTER 313. Human Herpesvirus 8

CHAPTER 314. Varicella-Zoster Virus Infections

CHAPTER 315. Human Immunodeficiency Virus Type 1 Infection

CHAPTER 316. Measles

CHAPTER 317. Molluscum Contagiosum

CHAPTER 318. Mumps

CHAPTER 319. Human Parvovirus

CHAPTER 320. Rubella

CHAPTER 321. Rabies

CHAPTER 322. Smallpox

CHAPTER 323. Antiparasitic Therapy

CHAPTER 324. Ascariasis

CHAPTER 325. Baylisascariasis

CHAPTER 326. Dracunculiasis

CHAPTER 327. Enterobiasis (Pinworm)

CHAPTER 328. Lymphatic Filariasis and Onchocerciasis

CHAPTER 329. Hookworm

CHAPTER 330. Strongyloidiasis

CHAPTER 331. Toxocariasis (Visceral and Ocular Larva Migrans)

CHAPTER 332. Trichinosis

CHAPTER 333. Trichuriasis

CHAPTER 334. Anasakiasis and Angiostrongyliasis

CHAPTER 335. Foodborne Trematodiasis and Schistosomiasis

CHAPTER 336. Diphyllobothriasis

CHAPTER 337. Dipylidiasis

CHAPTER 338. Echinococcosis

CHAPTER 339. Hymenolepiasis

CHAPTER 340. Taeniasis and Cysticercosis

CHAPTER 341. Amebiasis

CHAPTER 342. Babesiosis

CHAPTER 343. Balantidiasis

CHAPTER 344. Blastocystis hominis

CHAPTER 345. Cryptosporidiosis

CHAPTER 346. Cyclosporiasis

CHAPTER 347. Dientamoebiasis

CHAPTER 348. Free-Living Amebic Infections

CHAPTER 349. Giardiasis

CHAPTER 350. Isosporiasis

CHAPTER 351. Leishmaniasis

CHAPTER 352. Malaria

CHAPTER 353. Pneumocystis Pneumonia

CHAPTER 354. Toxoplasmosis

CHAPTER 355. Trypanosomiases

SECTION 18 Disorders of the Skin

CHAPTER 356. Functional Overview

CHAPTER 357. Neonatal Dermatology

CHAPTER 358. Disorders of the Epidermis

CHAPTER 359. Disorders of the Dermis and Subcutaneous Tissue

CHAPTER 360. Genetic Disorders of the Skin

CHAPTER 361. Melanocytic Lesions and Disorders of Pigmentation

CHAPTER 362. Immunologic Diseases

CHAPTER 363. Neoplastic and Proliferative Disorders

CHAPTER 364. Vascular Tumors and Malformations

CHAPTER 365. Acne and Other Disorders of the Pilosebaceous Unit

CHAPTER 366. Disorders of Nails

CHAPTER 367. Skin Infections and Exanthems

CHAPTER 368. Infestations

SECTION 19 Disorders of the Ear, Nose, and Throat

CHAPTER 369. The Ear

CHAPTER 370. Nose and Sinus

CHAPTER 371. The Pharynx and Upper Airway

CHAPTER 372. The Head, Face, and Neck

CHAPTER 373. Head and Neck Masses

SECTION 20 Disorders of the Oral Cavity

CHAPTER 374. Dental Caries

CHAPTER 375. Dental Emergency Care

CHAPTER 376. Dental Occlusion and Its Management

CHAPTER 377. Periodontal and Gingival Health and Diseases

CHAPTER 378. Oral Pathology

CHAPTER 379. Temporomandibular Joint Disorders

CHAPTER 380. Behavioral Treatment Options in Pediatric Dentistry

SECTION 21 Disorders of the Gastrointestinal System

CHAPTER 381. Normal Structure and Function of the Gastrointestinal Tract

CHAPTER 382. Approach to the Child with Acute, Chronic, or Cyclic Vomiting

CHAPTER 383. Acute Abdominal Pain

CHAPTER 384. Chronic Abdominal Pain

CHAPTER 385. Diarrhea

CHAPTER 386. Constipation and Fecal Incontinence

CHAPTER 387. Upper and Lower Gastrointestinal Bleeding

CHAPTER 388. Abdominal Masses

CHAPTER 389. Gastrointestinal Obstruction

CHAPTER 390. Protein-Losing Enteropathy

CHAPTER 391. Gastrointestinal Disorders Associated with Immunodeficiency

CHAPTER 392. Anatomic Disorders of the Esophagus

CHAPTER 393. Disorders of Esophageal Motility

CHAPTER 394. Gastroesophageal Reflux and Other Causes of Esophageal Inflammation

CHAPTER 395. Other Esophageal Disorders

CHAPTER 396. Abdominal Wall Defects

CHAPTER 397. Malrotation and Volvulus

CHAPTER 398. Infantile Hypertrophic Pyloric Stenosis

CHAPTER 399. Congenital Atresias, Stenosis, and Webs

CHAPTER 400. Microgastria and Gastric Perforation

CHAPTER 401. Duplications and Cysts

CHAPTER 402. Omphalo-Mesenteric Duct Remnants

CHAPTER 403. Meconium Diseases of Infancy and Distal Intestinal Obstruction Syndrome

CHAPTER 404. Intussusception

CHAPTER 405. Inguinal and Other Hernias

CHAPTER 406. Superior Mesenteric Artery Syndrome

CHAPTER 407. Motor Disorders of the Stomach, Small Bowel, and Colon

CHAPTER 408. Disorders of Digestion and Absorption

CHAPTER 409. Inflammatory Disorders of the Stomach

CHAPTER 410. Inflammatory Bowel Disease

CHAPTER 411. Allergic and Eosinophilic Gastroenteropathies

CHAPTER 412. Vascular, Systemic, and Other Disorders Affecting the Gastrointestinal Tract

CHAPTER 413. Acute Appendicitis, Typhlitis, and Chronic Appendicitis

CHAPTER 414. Polyps and Tumors of the Gastrointestinal Tract

CHAPTER 415. Congenital Anomalies of the Anorectum

CHAPTER 416. Other Anorectal Disorders

CHAPTER 417. Disorders of the Exocrine Pancreas

SECTION 22 Disorders of the Liver and Biliary Tract

CHAPTER 418. Structure and Function of the Liver

CHAPTER 419. Evaluation of the Infant and Child with Liver Disease

CHAPTER 420. Autoimmune Disorders of the Liver

CHAPTER 421. Metabolic and Genetic Disorders of the Liver

CHAPTER 422. Drug, Toxin, and TPN Liver Disease

CHAPTER 423. The Liver in Systemic Disease

CHAPTER 424. Acute Liver Failure

CHAPTER 425. End-Stage Liver Disease

CHAPTER 426. Other Disorders of the Liver

CHAPTER 427. The Biliary Tract

SECTION 23 Disorders of the Blood

CHAPTER 428. Approach to Suspected Hematologic Disorders

CHAPTER 429. Hematopoeisis

CHAPTER 430. Anemia

CHAPTER 431. Iron Deficiency

CHAPTER 432. Anemia Due to Diminished Red Blood Cell Production

CHAPTER 433. Hemolytic Anemia

CHAPTER 434. Hemoglobinopathies

CHAPTER 435. Normal and Abnormal Hemostasis

CHAPTER 436. Inherited Bleeding Disorders

CHAPTER 437. Acquired Coagulation Disorders

CHAPTER 438. Diagnosis and Management of Thrombosis

CHAPTER 439. Disorders of Platelets

CHAPTER 440. The Spleen and Lymph Nodes

CHAPTER 441. Disorders of Granulocytes

CHAPTER 442. Transfusion Medicine

SECTION 24 Neoplastic Disorders

CHAPTER 443. Cancer Genetics and Biology

CHAPTER 444. Epidemiology of Childhood Cancer

CHAPTER 445. Chemotherapy and Radiation Therapy

CHAPTER 446. Clinical Trials in Pediatric Oncology

CHAPTER 447. Neonatal Oncology

CHAPTER 448. Cancer Survivorship and Recommendations for Follow-Up

CHAPTER 449. Acute Lymphoblastic Leukemia

CHAPTER 450. Myeloid Malignancies

CHAPTER 451. Non-Hodgkin Lymphoma

CHAPTER 452. Hodgkin Lymphoma

CHAPTER 453. Osteosarcoma

CHAPTER 454. Ewing Sarcoma and Primitive Neuroectodermal Tumor

CHAPTER 455. Rhabdomyosarcoma

CHAPTER 456. Renal Tumors

CHAPTER 457. Neuroblastoma

CHAPTER 458. Malignant Liver Tumors

CHAPTER 459. Germ Cell Tumors

CHAPTER 460. Brain Tumors and Spinal Tumors

CHAPTER 461. Retinoblastoma

CHAPTER 462. Vascular Neoplasms

CHAPTER 463. Histiocytic Disorders

SECTION 25 Disorders of the Kidney and Urinary Tract

CHAPTER 464. Renal Morphogenesis

CHAPTER 465. Development of Renal Function

CHAPTER 466. Fluid, Electrolyte, and Acid-Base Disorders

CHAPTER 467. Diagnostic Approach to Renal Disease

CHAPTER 468. Kidney or Urinary Tract Disorders

CHAPTER 469. Renal Malformations

CHAPTER 470. Cystic Diseases of the Kidney

CHAPTER 471. Acute Renal Failure

CHAPTER 472. Glomerular Diseases

CHAPTER 473. Hereditary Glomerulopathies

CHAPTER 474. Renal Tubular Disorders

CHAPTER 475. Urinary Tract Stone Diseases

CHAPTER 476. Urologic Abnormalities of the Genitourinary Tract

CHAPTER 477. Chronic Kidney Disease

CHAPTER 478. Chronic Dialysis

CHAPTER 479. Systemic Hypertension

SECTION 26 Disorders of the Cardiovascular System

CHAPTER 480. Development of the Cardiovascular System

CHAPTER 481. Genetics of Heart Disease

CHAPTER 482. Fetal Cardiology

CHAPTER 483. Neonate and Infant with Cardiovascular Disease

CHAPTER 484. Congenital Heart Disease

CHAPTER 485. Arrhythmias

CHAPTER 486. Child and Adolescent with Cardiovascular Disease

CHAPTER 487. Cardiac Tumors

CHAPTER 488. Kawasaki Disease

CHAPTER 489. Diseases of Myocardium

CHAPTER 490. Infective Endocarditis

CHAPTER 491. Pericardial Diseases

CHAPTER 492.Pulmonary Hypertension

CHAPTER 493. Electrocardiography

CHAPTER 494. Radiologic Imaging

CHAPTER 495. Echocardiography

CHAPTER 496. Cardiac Catherization

CHAPTER 497. Heart Failure

CHAPTER 498. The Patient with Single Ventricle

CHAPTER 499. Interventional Cardiology

CHAPTER 500. Health Care Management for the Child with Cardiovascular Disease

CHAPTER 501. Sports Screening for Cardiovascular Risk

SECTION 27 Disorders of the Respiratory System

CHAPTER 502. Lung Growth in Infancy and Childhood

CHAPTER 503. Physiologic Basis of Pulmonary Function

CHAPTER 504. Global Burden of Respiratory Infections and Mucosal Immunology of the Respiratory Tract

CHAPTER 505. Clinical Presentation of Respiratory Illness

CHAPTER 506. Tools for Diagnosis and Management of Respiratory Disease

CHAPTER 507. Congenital Disorders of the Lower Airways and Mediastinum

CHAPTER 508. Disorders of Respiratory Control and Sleep-Disordered Breathing

CHAPTER 509. Sleep Disorders

CHAPTER 510. Disorders Causing Airway Obstruction

CHAPTER 511. Aspiration Syndromes

CHAPTER 512. Asthma

CHAPTER 513. Bronchopulmonary Dysplasia

CHAPTER 514. Cystic Fibrosis

CHAPTER 515. Interstitial Lung Disease

CHAPTER 516. Alpha-1 Antitrypsin Deficiency Lung Disease

CHAPTER 517. Pulmonary Vasculitis Syndromes

CHAPTER 518. Pulmonary Alveolar Proteinosis

CHAPTER 519. Chest Wall and Respiratory Muscle Disorders

SECTION 28 Disorders of the Endocrine System

CHAPTER 520. Mechanisms of Hormone Action

CHAPTER 521. Disorders of the Anterior Pituitary Gland

CHAPTER 522. Growth and Growth Impairment

CHAPTER 523. Endocrine Abnormalities Causing Growth Impairment

CHAPTER 524. Tall Stature

CHAPTER 525. Primary Disturbances in Water Homeostasis

CHAPTER 526. The Thyroid

CHAPTER 527. Hypothyroidism in the Infant

CHAPTER 528. Acquired Hypothyroidism

CHAPTER 529. Hyperthyroidism

CHAPTER 530. Other Disorders of the Thyroid

CHAPTER 531. The Adrenal Cortex

CHAPTER 532. Evaluation of Adrenal Function

CHAPTER 533. Genetic Lesions in Steroidogenesis

CHAPTER 534. Adrenal Insufficiency

CHAPTER 535. Adrenal Excess

CHAPTER 536. Glucocorticoid Therapy and Withdrawal

CHAPTER 537. Endocrine Neoplasia Syndromes

CHAPTER 538. Normal Human Sex Differentiation

CHAPTER 539. Disorders of Sexual Development (DSD)

CHAPTER 540. Normal Pubertal Development

CHAPTER 541. Abnormal Pubertal Development

CHAPTER 542. Calcium, Phosphorus, and Magnesium Metabolism

CHAPTER 543. Disorders of Bone Formation

CHAPTER 544. Diabetes Mellitus

CHAPTER 545. Endocrine Causes of Hypoglycemia

SECTION 29 Disorders of the Nervous System

CHAPTER 546. Introduction to Neurology

CHAPTER 547. Clinical Approach to Neurologic Disease

CHAPTER 548. Cranial Developmental Abnormalities

CHAPTER 549. Disturbances of the Neural Tube and Spine Closure

CHAPTER 550. Macrocephaly and Microcephaly

CHAPTER 551. Trauma to the Nervous System

CHAPTER 552. Stroke and Cerebrovascular Disease

CHAPTER 553. Hydrocephalus and Pseudotumor Cerebri

CHAPTER 554. Cerebral Palsy and Static Encephalopathies

CHAPTER 555. Infections of the Central Nervous System

CHAPTER 556. Immune- and Inflammatory-Mediated Central Nervous System Syndromes

CHAPTER 557. Epidemiology of Epilepsy, Seizure Classification, Epilepsy Syndromes

CHAPTER 558. Etiologies of Epilepsies

CHAPTER 559. Febrile Seizures

CHAPTER 560. Evaluation of New Onset Seizures

CHAPTER 561. Status Epilepticus

CHAPTER 562. Epilepsy Treatment: Antiepileptic Drug Therapy

CHAPTER 563. Epilepsy Treatment: Ketogenic Diet and Neurostimulation

CHAPTER 564. Epilepsy Treatment: Surgery

CHAPTER 565. Migraine and Headache Disorders

CHAPTER 566. Movement Disorders, Tics, and Tourette Syndrome

CHAPTER 567. Other Paroxysmal Disorders

CHAPTER 568. General Evaluation of Strength, Tone, and Sensation

CHAPTER 569. The Hypotonic Infant

CHAPTER 570. Peripheral Nerve Disorders and Anterior Horn Cell Diseases

CHAPTER 571. Diseases of the Neuromuscular Junction

CHAPTER 572. Myopathies

CHAPTER 573. Neurologic Aspects of Disorders of Metal Metabolism

CHAPTER 574. Lysosomal Storage Disorders

CHAPTER 575. Rett Syndrome (MECP2-Related Disorders)

CHAPTER 576. Leukoencephalopathies

CHAPTER 577. Neurotransmitter Disorders

CHAPTER 578. Phakomatoses

SECTION 30 Disorders of the Eyes

CHAPTER 579. Anatomy and Physiology of the Eye and Ocular System

CHAPTER 580. Office Evaluation of the Eyes

CHAPTER 581. Special Tests of the Eyes

CHAPTER 582. International Pediatric Ophthalmology

CHAPTER 583. Eye Emergencies and Trauma

CHAPTER 584. Visual Impairment in Childhood

CHAPTER 585. Amblyopia

CHAPTER 586. Strabismus

CHAPTER 587. The Eye in Child Abuse

CHAPTER 588. Red Eye

CHAPTER 589. Lid and Lacrimal System Disorders

CHAPTER 590. Anterior Segment Disorders

CHAPTER 591. Retinopathy of Prematurity

CHAPTER 592. Genetic Eye Diseases

CHAPTER 593. Optic Nerve Disorders