THE APhA COMPLETE REVIEW FOR PHARMACY, 7th Ed

Appendix J: Use-in-Pregnancy Ratings

Introduction

The U.S. Food and Drug Administration's Use-in-Pregnancy rating system weighs the degree to which available information has ruled out risk to the fetus against the drug's potential benefit to the patient. The following is a list of drugs (by generic name) for which ratings are available.

X: Contraindication In Pregnancy

Studies in animals or humans or investigational or postmarketing reports have demonstrated fetal risk, which clearly outweighs any possible benefit to the patient.

Acetohydroxamic acid

Acitretin

Ambrisentan

Amlodipine besylate-atorvastatin calcium

Anisindione

Atorvastatin calcium

Bexarotene

Bicalutamide

Bosentan

Cetrorelix acetate

Clomiphene citrate

Desogestrel-ethinyl estradiol

Diclofenac sodium-misoprostol

Dihydroergotamine mesylate

Dutasteride

Estazolam

Estradiol

Estradiol acetate

Estradiol cypionate-medroxyprogesterone acetate

Estradiol-levonorgestrel

Estradiol-norethindrone acetate

Estradiol valerate

Estrogens (conjugated)

Estrogens (conjugated)-medroxyprogesterone acetate

Estrogens (conjugated, synthetic A)

Estrogens (esterified)

Estrogens (esterified)-methyltestosterone

Estropipate

Ethinyl estradiol-drospirenone

Ethinyl estradiol-ethynodiol diacetate

Ethinyl estradiol-etonogestrel

Ethinyl estradiol-ferrous fumarate-norethindrone acetate

Ethinyl estradiol-levonorgestrel

Ethinyl estradiol-norelgestromin

Ethinyl estradiol-norethindrone

Ethinyl estradiol-norethindrone acetate

Ethinyl estradiol-norgestimate

Ethinyl estradiol-norgestrel

Ezetimibe-simvastatin

Finasteride

Fluorouracil

Fluoxymesterone

Flurazepam hydrochloride

Fluvastatin sodium

Follitropin alfa

Follitropin beta

Ganirelix acetate

Goserelin acetate

Histrelin acetate

Hydromorphone hydrochloride

Interferon alfa-2B (recombinant)-ribavirin

Iodine I 131 tositumomab-tositumomab

Isotretinoin

Leflunomide

Leuprolide acetate

Levonorgestrel

Lovastatin

Lovastatin-niacin

Medroxyprogesterone acetate

Megestrol acetate

Menotropins

Mequinol-tretinoin

Mestranol-norethindrone

Methotrexate sodium

Methyltestosterone

Miglustat

Misoprostol

Nafarelin acetate

Niacin-simvastatin

Norethindrone

Norethindrone acetate

Norgestrel

Oxandrolone

Oxymetholone

Plicamycin

Pravastatin sodium

Pravastatin sodium-aspirin (buffered)

Raloxifene hydrochloride

Ribavirin

Rosuvastatin calcium

Simvastatin

Tazarotene

Testosterone

Testosterone enanthate

Thalidomide

Tositumomab

Triptorelin pamoate

Warfarin sodium

D: Positive Evidence of Risk

Investigational or postmarketing data show risk to the fetus. Nevertheless, potential benefits may outweigh the potential risk.

Aliskiren*

Aliskiren-hydrochlorothiazide

Alitretinoin

Alprazolam

Altretamine

Amiodarone hydrochloride

Amlodipine besylate-benazepril hydrochloride

Amlodipine besylate-olmesartan medoxomil

Amlodipine besylate-valsartan*

Anastrozole

Arsenic trioxide

Aspirin (buffered)-pravastatin sodium

Aspirin-dipyridamole

Atenolol

Azacitidine

Azathioprine

Azathioprine sodium

Benazepril hydrochloride*

Benazepril hydrochloride-hydrochlorothiazide*

Bendamustine hydrochloride

Bortezomib

Busulfan

Candesartan cilexetil*

Candesartan cilexetil-hydrochlorothiazide*

Capecitabine

Captopril*

Carbamazepine

Carboplatin

Carmustine (BiCNU)

Chlorambucil

Cladribine

Clofarabine

Clonazepam

Cytarabine liposome

Dactinomycin

Dasatinib

Daunorubicin citrate liposome

Daunorubicin hydrochloride

Demeclocycline hydrochloride

Dexrazoxane

Dexrazoxane hydrochloride

Diazepam

Divalproex sodium

Docetaxel

Doxorubicin hydrochloride

Doxorubicin hydrochloride liposome

Doxycycline

Doxycycline calcium

Doxycycline hyclate

Doxycycline monohydrate

Efavirenz

Enalapril maleate*

Enalapril maleate-hydrochlorothiazide*

Epirubicin hydrochloride

Eprosartan mesylate

Erlotinib

Exemestane

Floxuridine

Fludarabine phosphate

Flutamide

Fosinopril sodium*

Fosinopril sodium-hydrochlorothiazide*

Fosphenytoin sodium

Fulvestrant

Gefitinib

Gemcitabine hydrochloride

Gemtuzumab ozogamicin

Genistein-zinc chelazome-cholecalciferol

Goserelin acetate

Ibritumomab tiuxetan

Idarubicin hydrochloride

Ifosfamide

Imatinib mesylate

Irbesartan*

Irbesartan-hydrochlorothiazide*

Irinotecan hydrochloride

Ixabepilone

Letrozole

Lisinopril*

Lisinopril-hydrochlorothiazide*

Lithium carbonate

Losartan potassium*

Losartan potassium-hydrochlorothiazide*

Mechlorethamine hydrochloride

Melphalan

Melphalan hydrochloride

Mephobarbital

Mercaptopurine

Methimazole

Midazolam hydrochloride

Minocycline hydrochloride

Mitoxantrone hydrochloride

Moexipril hydrochloride*

Moexipril hydrochloride-hydrochlorothiazide*

Mycophenolate mofetil

Mycophenolic acid

Nelarabine

*Category C or D depending on the trimester the drug is given.

Neomycin sulfate-polymyxin B sulfate

Nicotine

Nilotinib

Nilotinib hydrochloride monohydrate

Olmesartan medoxomil

Oxaliplatin

Pamidronate disodium

Paroxetine hydrochloride

Paroxetine mesylate

Pemetrexed

Penicillamine

Pentobarbital sodium

Pentostatin

Perindopril erbumine*

Phenytoin

Procarbazine hydrochloride

Quinapril hydrochloride*

Quinapril hydrochloride-hydrochlorothiazide*

Ramipril*

Sorafenib

Streptomycin sulfate

Sunitinib

Tamoxifen citrate

Telmisartan

Telmisartan-hydrochlorothiazide

Temozolomide

Temsirolimus

Thioguanine

Tigecycline

Tobramycin

Topotecan hydrochloride

Toremifene citrate

Trandolapril*

Trandolapril-verapamil hydrochloride*

Tretinoin

Valproate sodium

Valproic acid

Valsartan*

Valsartan-hydrochlorothiazide*

Vinorelbine tartrate

Voriconazole

Zoledronic acid

C: Risk Cannot Be Ruled Out

Human studies are lacking, and animal studies are either positive for risk or lacking as well. However, potential benefits may outweigh the potential risk.

Abacavir sulfate

Abacavir sulfate-lamivudine

Abacavir sulfate-lamivudine-zidovudine

Abciximab

Acamprosate calcium

Acetaminophen

Acetaminophen-butalbital-caffeine

Acetaminophen-caffeine-chlorpheniramine maleate-hydrocodone bitartrate-phenylephrine hydrochloride

Acetazolamide

Acetazolamide sodium

Acyclovir

Adapalene

Adefovir dipivoxil

Adenosine

Alatrofloxacin mesylate

Albendazole

Albumin (human)

Albuterol

Albuterol sulfate

Albuterol sulfate-ipratropium bromide

Alclometasone dipropionate

Aldesleukin

Alemtuzumab

Alendronate sodium

Alendronate sodium-cholecalciferol

Aliskiren*

Allopurinol sodium

Almotriptan malate

Alpha1-proteinase inhibitor (human)

Alprostadil

Alteplase

Amantadine hydrochloride

Amifostine

Aminocaproic acid

Aminohippurate sodium

Aminolevulinic acid hydrochloride

Aminosalicylic acid

Amlodipine besylate

Amlodipine besylate-benazepril hydrochloride

Amlodipine besylate-olmesartan medoxomil*

Amlodipine besylate-valsartan*

Amoxicillin-clarithromycin-lansoprazole

Amphetamine aspartate-amphetamine sulfate-dextroamphetamine saccharate-dextroamphetamine sulfate

Amprenavir

Anagrelide hydrochloride

Anthralin

Antihemophilic factor (human)

Antihemophilic factor (recombinant)

Anti-inhibitor coagulant complex

Antithymocyte globulin

Apomorphine hydrochloride

*Category C or D depending on the trimester the drug is given.

Aripiprazole

Armodafinil

Arnica montana-herbals (multiple)-sulfur

Asparaginase

Atomoxetine hydrochloride

Atovaquone

Atovaquone-proguanil hydrochloride

Atropine sulfate-benzoic acid-hyoscyamine sulfate-methenamine-methylene blue-phenyl salicylate

Atropine sulfate-hyoscyamine sulfate-scopolamine hydrobromide

Azelastine hydrochloride

Bacitracin zinc-neomycin sulfate-polymyxin B sulfate

Baclofen

BCG (live, intravesical)

Becaplermin

Beclomethasone dipropionate

Beclomethasone dipropionate monohydrate

Benazepril hydrochloride*

Benazepril hydrochloride-hydrochlorothiazide*

Bendroflumethiazide

Benzocaine

Benzonatate

Benzoyl peroxide

Benzoyl peroxide-clindamycin

Benzoyl peroxide-erythromycin

Betamethasone dipropionate

Betamethasone dipropionate-clotrimazole

Betamethasone valerate

Betaxolol hydrochloride

Bethanechol chloride

Bevacizumab

Bimatoprost

Bisacodyl-polyethylene glycol-potassium chloride-sodium bicarbonate-sodium chloride

Bisoprolol fumarate

Bisoprolol fumarate-hydrochlorothiazide

Bitolterol mesylate

Black widow spider antivenin (equine)

Botulinum toxin type A

Botulinum toxin type B

Brimonidine tartrate-timolol maleate

Brinzolamide

Brompheniramine maleate-dextromethorphan hydrobromide-phenylephrine hydrochloride

Budesonide

Bupivacaine hydrochloride

Bupivacaine hydrochloride-epinephrine bitartrate

Buprenorphine hydrochloride

Buprenorphine hydrochloride-naloxone hydrochloride

Bupropion hydrobromide

Bupropion hydrochloride

Butabarbital-hyoscyamine hydrobromide-phenazopyridine hydrochloride

Butalbital-acetaminophen

Butenafine hydrochloride

Butoconazole nitrate

Butorphanol tartrate

Caffeine citrate

Calcipotriene

Calcitonin-salmon

Calcitriol

Calcium acetate

Candesartan cilexetil*

Candesartan cilexetil-hydrochlorothiazide*

Capreomycin sulfate

Captopril*

Carbetapentane tannate-chlorpheniramine tannate

Carbetapentane tannate-chlorpheniramine tannate-ephedrine tannate-phenylephrine tannate

Carbidopa-entacapone-levodopa

Carbidopa-levodopa

Carbinoxamine maleate-dextromethorphan hydrobromide-pseudoephedrine hydrochloride

Carteolol hydrochloride

Carvedilol

Caspofungin acetate

Celecoxib

Cetirizine hydrochloride

Cetuximab

Cevimeline hydrochloride

Chloramphenicol

Chloroprocaine hydrochloride

Chlorothiazide

Chlorothiazide sodium

Chlorpheniramine maleate-methscopolamine nitrate-phenylephrine hydrochloride

Chlorpheniramine maleate-pseudoephedrine hydrochloride

Chlorpheniramine polistirex-hydrocodone polistirex

Chlorpheniramine tannate-phenylephrine tannate

Chlorpropamide

Chlorthalidone-clonidine hydrochloride

Choline magnesium trisalicylate

Ciclesonide

Cidofovir

Cilostazol

Cinacalcet hydrochloride

Ciprofloxacin-dexamethasone

*Category C or D depending on the trimester the drug is given.

Ciprofloxacin hydrochloride

Ciprofloxacin hydrochloride-hydrocortisone

Citalopram hydrobromide

Clarithromycin

Clobetasol propionate

Clonidine

Clonidine hydrochloride

Codeine phosphate-acetaminophen

Colistimethate sodium

Colistin sulfate-hydrocortisone acetate-neomycin sulfate-thonzonium bromide

Corticorelin ovine triflutate

Cyanocobalamin

Cycloserine

Cyclosporine

Cytomegalovirus immune globulin

Dacarbazine

Daclizumab

Dantrolene sodium

Dapsone

Darbepoetin alfa

Darifenacin

Deferoxamine mesylate

Delavirdine mesylate

Denileukin diftitox

Desloratadine

Desloratadine-pseudoephedrine sulfate

Desoximetasone

Desvenlafaxine

Dexamethasone

Dexamethasone sodium phosphate

Dexmethylphenidate hydrochloride

Dexrazoxane

Dextroamphetamine sulfate

Diazoxide

Dichlorphenamide

Diclofenac epolamine

Diclofenac potassium

Diclofenac sodium

Diflorasone diacetate

Diflunisal

Digoxin

Digoxin immune Fab (ovine)

Diltiazem hydrochloride

Dimethyl sulfoxide

Dinoprostone

Diphtheria and tetanus toxoids and acellular pertussis vaccine (adsorbed)

Diphtheria and tetanus toxoids and acellular pertussis vaccine (adsorbed)-hepatitis B Vaccine, (recombinant)-poliovirus vaccine (inactivated)

Dirithromycin

Dofetilide

Donepezil hydrochloride

Dorzolamide hydrochloride

Dorzolamide hydrochloride-timolol maleate

Doxazosin mesylate

Dronabinol

Drotrecogin alfa (activated)

Duloxetine hydrochloride

Echothiophate iodide

Econazole nitrate

Efalizumab

Eflornithine hydrochloride

Eletriptan hydrobromide

Enalapril maleate*

Enalapril maleate-felodipine*

Enalapril maleate-hydrochlorothiazide*

Entacapone

Entecavir

Epinastine hydrochloride

Epinephrine

Epoetin alfa

Eprosartan mesylate

Erythromycin ethylsuccinate-sulfisoxazole acetyl

Escitalopram oxalate

Eszopiclone

Ethionamide

Ethotoin

Etidronate disodium

Exenatide

Ezetimibe

Factor IX complex

Felodipine

Fenofibrate

Fentanyl

Fentanyl citrate

Fentanyl hydrochloride

Ferrous fumarate-folic acid-intrinsic factor concentrate-liver preparations-vitamin B12-vitamin C-vitamins with iron

Fexofenadine hydrochloride

Fexofenadine hydrochloride-pseudoephedrine hydrochloride

Filgrastim

Flecainide acetate

Fluconazole

Flucytosine

Fludrocortisone acetate

Flumazenil

Flunisolide

Fluocinolone acetonide

*Category C or D depending on the trimester the drug is given.

Fluocinolone acetonide-hydroquinone-tretinoin

Fluocinonide

Fluorometholone

Fluorometholone-sulfacetamide sodium

Fluoxetine hydrochloride

Fluoxetine hydrochloride-olanzapine

Flurandrenolide

Flurbiprofen sodium

Fluticasone furoate

Fluticasone propionate

Fluticasone propionate HFA

Fluticasone propionate-salmeterol xinafoate

Fluvoxamine maleate

Fomivirsen sodium

Formoterol fumarate

Fosamprenavir calcium

Foscarnet sodium*

Fosinopril sodium*

Fosinopril sodium-hydrochlorothiazide*

Frovatriptan succinate

Furosemide

Gabapentin

Gallium nitrate

Ganciclovir

Ganciclovir sodium

Gatifloxacin

Gemfibrozil

Gemifloxacin mesylate

Gentamicin sulfate

Gentamicin sulfate-prednisolone acetate

Glimepiride

Glimepiride-rosiglitazone maleate

Glipizide

Glipizide-metformin hydrochloride

Globulin, immune (human)

Globulin, immune (human)-Rho (D) immune globulin (human)

Glyburide

Gramicidin-neomycin sulfate-polymyxin B sulfate

Guaifenesin-hydrocodone bitartrate

Haemophilus B conjugate vaccine

Haemophilus B conjugate vaccine-hepatitis B vaccine (recombinant)

Halobetasol propionate

Haloperidol decanoate

Hemin

Heparin sodium

Hepatitis A vaccine (inactivated)

Hepatitis A vaccine (inactivated)-hepatitis B vaccine (recombinant)

Hepatitis B immune globulin (human)

Hepatitis B vaccine (recombinant)

Homatropine methylbromide-hydrocodone bitartrate

Homeopathic formulations

Hydralazine hydrochloride-isosorbide dinitrate

Hydrochlorothiazide

Hydrocodone bitartrate

Hydrocodone bitartrate-acetaminophen

Hydrocodone bitartrate-ibuprofen

Hydrocortisone

Hydrocortisone acetate

Hydrocortisone acetate-neomycin sulfate-polymyxin B sulfate

Hydrocortisone acetate-pramoxine hydrochloride

Hydrocortisone butyrate

Hydrocortisone-neomycin sulfate-polymyxin B sulfate

Hydrocortisone probutate

Hydromorphone hydrochloride

Hydroquinone

Hyoscyamine sulfate

Ibandronate sodium

Ibutilide fumarate

Iloprost

Imiglucerase

Imipenem-cilastatin

Imiquimod

Immune globulin intravenous (human)

Indinavir sulfate

Indocyanine green

Influenza virus vaccine

Insulin aspart

Insulin aspart protamine (human)-insulin aspart (human)

Insulin glargine

Insulin glulisine

Interferon alfa-2B (recombinant)

Interferon alfacon-1

Interferon alfa-N3 (human leukocyte derived)

Interferon beta-1A

Interferon beta-1B

Interferon gamma-1B

Iodoquinol-hydrocortisone

Irbesartan*

Irbesartan-hydrochlorothiazide*

Iron dextran

Isoniazid-pyrazinamide-rifampin

Isosorbide mononitrate

Isradipine

Itraconazole

Ivermectin

*Category C or D depending on the trimester the drug is given.

Ketoconazole

Ketorolac tromethamine

Ketotifen fumarate

Labetalol hydrochloride

Lamivudine

Lamivudine-zidovudine

Lamotrigine

Lanreotide acetate

Lanthanum carbonate

Latanoprost

Levalbuterol hydrochloride

Levalbuterol tartrate

Levamisole hydrochloride

Levetiracetam

Levobunolol hydrochloride

Levofloxacin

Linezolid

Lisdexamfetamine

Lisinopril*

Lisinopril-hydrochlorothiazide*

Lomefloxacin

Lopinavir-ritonavir

Losartan potassium*

Losartan potassium-hydrochlorothiazide*

Loteprednol etabonate

Lubiprostone

Mafenide acetate

Magnesium salicylate tetrahydrate

Measles, mumps, and rubella virus vaccine (live)

Measles virus vaccine (live)

Mebendazole

Mecamylamine hydrochloride

Mecasermin [rDNA origin]

Medrysone

Mefenamic acid

Mefloquine hydrochloride

Meloxicam

Meningococcal polysaccharide diphtheria toxoid conjugate vaccine

Meningococcal polysaccharide vaccine

Meperidine hydrochloride

Mepivacaine hydrochloride

Metaproterenol sulfate

Metaraminol bitartrate

Metformin hydrochloride-pioglitazone hydrochloride

Metformin hydrochloride-repaglinide

Metformin hydrochloride-rosiglitazone maleate

Methamphetamine hydrochloride

Methazolamide

Methenamine mandelate-sodium acid phosphate

Methocarbamol

Methoxsalen

Methoxy polyethylene glycol-epoetin beta

Methscopolamine nitrate-pseudoephedrine hydrochloride

Methyldopa-chlorothiazide

Methyldopa-hydrochlorothiazide

Methylphenidate hydrochloride

Metipranolol

Metoprolol succinate

Metoprolol tartrate

Metoprolol tartrate-hydrochlorothiazide

Metyrosine

Mexiletine hydrochloride

Micafungin sodium

Midodrine hydrochloride

Mivacurium chloride

Modafinil

Moexipril hydrochloride*

Moexipril hydrochloride-hydrochlorothiazide*

Mometasone furoate

Mometasone furoate monohydrate

Morphine sulfate

Morphine sulfate, liposomal

Moxifloxacin hydrochloride

Mumps virus vaccine (live)

Muromonab-CD3

Mycophenolate mofetil

Mycophenolate mofetil hydrochloride

Mycophenolic acid

Nabumetone

Nadolol

Nadolol-bendroflumethiazide

Naloxone hydrochloride-pentazocine hydrochloride

Naltrexone hydrochloride

Naphazoline hydrochloride

Naproxen

Naproxen sodium

Naratriptan hydrochloride

Natamycin

Nateglinide

Nebivolol

Nefazodone hydrochloride

Neomycin sulfate-dexamethasone sodium phosphate

Neomycin sulfate-polymyxin B sulfate-prednisolone acetate

Nesiritide

Nevirapine

Niacin

Nicardipine hydrochloride

*Category C or D depending on the trimester the drug is given.

Nifedipine

Nilutamide

Nimodipine

Nisoldipine

Nitroglycerin

Norfloxacin

Ofloxacin

Olanzapine

Olmesartan medoxomil-hydrochlorothiazide

Olopatadine hydrochloride

Olsalazine sodium

Omega-3-acid ethyl esters

Omeprazole

Oprelvekin

Orphenadrine citrate

Oseltamivir phosphate

Oxcarbazepine

Oxycodone hydrochloride-acetaminophen

Oxycodone hydrochloride-ibuprofen

Oxymorphone hydrochloride

Palifermin

Paliperidone

Palivizumab

Pancrelipase

Paricalcitol

Paroxetine hydrochloride

Paroxetine mesylate

PEG-3350-potassium chloride-sodium bicarbonate-sodium chloride

Pegademase bovine

Pegaspargase

Pegfilgrastim

Peginterferon alfa-2A

Peginterferon alfa-2B

Pemirolast potassium

Pentazocine hydrochloride-acetaminophen

Pentoxifylline

Perindopril erbumine*

Phenoxybenzamine hydrochloride

Phentermine hydrochloride

Pilocarpine hydrochloride

Pimecrolimus

Pimozide

Pioglitazone hydrochloride

Pirbuterol acetate

Piroxicam

Plasma fractions (human)-rabies immune globulin (human)

Plasma protein fraction (human)

Pneumococcal vaccine (diphtheria conjugate)

Pneumococcal vaccine (polyvalent)

Podofilox

Polyethylene glycol

Polyethylene glycol-potassium chloride-sodium bicarbonate-sodium chloride

Polyethylene glycol-potassium chloride-sodium bicarbonate-sodium chloride-sodium sulfate

Polymyxin B sulfate-trimethoprim sulfate

Polythiazide-prazosin hydrochloride

Porfimer sodium

Potassium acid phosphate

Potassium chloride

Potassium citrate

Potassium phosphate-sodium phosphate

Pralidoxime chloride

Pramipexole dihydrochloride

Pramlintide acetate

Pramoxine hydrochloride-hydrocortisone acetate

Prazosin hydrochloride

Prednisolone acetate

Prednisolone acetate-sulfacetamide sodium

Prednisolone sodium phosphate

Pregabalin

Promethazine hydrochloride

Propafenone hydrochloride

Proparacaine hydrochloride

Propranolol hydrochloride

Pseudoephedrine hydrochloride

Pyrimethamine

Quetiapine fumarate

Quinapril hydrochloride*

Quinidine sulfate

Rabies vaccine

Raltegravir potassium

Ramelteon

Ramipril*

Ranolazine

Rasburicase

Remifentanil hydrochloride

Repaglinide

Reteplase

Rho (D) immune globulin (human)

Rifampin

Rifapentine

Rifaximin

Riluzole

Rimantadine hydrochloride

Risedronate sodium

Risedronate sodium-calcium carbonate

Risperidone

Rituximab

Rizatriptan benzoate

Rocuronium bromide

Rofecoxib

*Category C or D depending on the trimester the drug is given.

Romiplostim

Ropinirole hydrochloride

Rosiglitazone maleate

Rotigotine

Rubella virus vaccine (live)

Salmeterol xinafoate

Sapropterin dihydrochloride

Sargramostim

Scopolamine

Selegiline hydrochloride

Selenium sulfide

Sertaconazole nitrate

Sertraline hydrochloride

Sevelamer carbonate

Sevelamer hydrochloride

Sibutramine hydrochloride monohydrate

Sirolimus

Sodium benzoate-sodium phenylacetate

Sodium phenylbutyrate

Sodium polystyrene sulfonate

Sodium sulfacetamide-sulfur

Solifenacin succinate

Somatropin

Somatropin (rDNA origin)

Stavudine

Streptokinase

Succimer

Sulfacetamide sodium

Sulfamethoxazole-trimethoprim

Sulfanilamide

Sumatriptan

Sumatriptan succinate

Tacrine hydrochloride

Tacrolimus

Telithromycin

Telmisartan*

Telmisartan-hydrochlorothiazide*

Tenecteplase

Terazosin hydrochloride

Teriparatide

Tetanus and diphtheria toxoids (adsorbed)

Tetanus immune globulin (human)

Theophylline

Theophylline anhydrous

Thiabendazole

Thrombin

Thyrotropin alfa

Tiagabine hydrochloride

Tiludronate disodium

Timolol hemihydrate

Timolol maleate

Timolol maleate-hydrochlorothiazide

Tinidazole

Tiotropium bromide

Tipranavir

Tizanidine hydrochloride

Tobramycin-dexamethasone

Tobramycin-loteprednol etabonate

Tolcapone

Tolterodine tartrate

Topiramate

Tramadol hydrochloride

Tramadol hydrochloride-acetaminophen

Trandolapril*

Trandolapril-verapamil hydrochloride*

Travoprost

Tretinoin

Triamcinolone acetonide

Triamterene

Triamterene-hydrochlorothiazide

Trientine hydrochloride

Triethanolamine polypeptide oleate-condensate

Trifluridine

Trimethoprim hydrochloride

Trimipramine maleate

Tropicamide-hydroxyamphetamine hydrobromide

Trospium chloride

Trovafloxacin mesylate

Tuberculin purified protein derivative (diluted)

Typhoid vaccine (live) oral Ty21a

Unoprostone isopropyl

Urea

Valdecoxib

Valganciclovir hydrochloride

Valsartan*

Valsartan-hydrochlorothiazide*

Varenicline tartrate

Varicella virus vaccine (live)

Venlafaxine hydrochloride

Verapamil hydrochloride

Verteporfin

Vitamin K1

Yellow fever vaccine

Zalcitabine

Zaleplon

Zanamivir

Zidovudine

Ziprasidone mesylate

Zolmitriptan

Zolpidem tartrate

Zonisamide

*Category C or D depending on the trimester the drug is given.

B: No Evidence of Risk in Humans

Animal findings show risk whereas human findings do not, or, if no adequate human studies have been done, animal findings are negative.

Acarbose

Acrivastine

Acyclovir

Acyclovir sodium

Adalimumab

Agalsidase beta

Alefacept

Alfuzosin hydrochloride

Alosetron hydrochloride

Alvimopan

Amiloride hydrochloride

Amiloride hydrochloride-hydrochlorothiazide

Amoxicillin

Amoxicillin-clavulanate potassium

Amphotericin B

Amphotericin B-cholesteryl sulfate complex

Amphotericin B lipid complex

Amphotericin B (liposomal)

Ampicillin sodium-sulbactam sodium

Anakinra

Antithrombin III

Aprepitant

Aprotinin

Argatroban

Arginine hydrochloride

Atazanavir sulfate

Azelaic acid

Azithromycin

Azithromycin dihydrate

Aztreonam

Balsalazide disodium

Basiliximab

Bivalirudin

Brimonidine tartrate

Budesonide

Bupropion hydrochloride

Cabergoline

Carbenicillin indanyl sodium

Cefaclor

Cefazolin sodium

Cefdinir

Cefditoren pivoxil

Cefepime hydrochloride

Cefixime

Cefoperazone sodium

Cefotaxime sodium

Cefotetan disodium

Cefoxitin sodium

Cefpodoxime proxetil

Cefprozil

Ceftazidime sodium

Ceftibuten dihydrate

Ceftizoxime sodium

Ceftriaxone sodium

Cefuroxime

Cefuroxime axetil

Cephalexin

Certolizumab pegol

Cetirizine hydrochloride

Ciclopirox

Ciclopirox olamine

Cimetidine

Cimetidine hydrochloride

Cisatracurium besylate

Clindamycin hydrochloride-clindamycin phosphate

Clindamycin palmitate hydrochloride

Clindamycin phosphate

Clopidogrel bisulfate

Clotrimazole

Clozapine

Colesevelam hydrochloride

Cromolyn sodium

Cyclobenzaprine hydrochloride

Cyproheptadine hydrochloride

Dalfopristin-quinupristin

Dalteparin sodium

Dapiprazole hydrochloride

Daptomycin

Desflurane

Desmopressin acetate

Dicyclomine hydrochloride

Didanosine

Diphenhydramine hydrochloride

Dipivefrin hydrochloride

Dipyridamole

Dolasetron mesylate

Doripenem

Dornase alfa

Doxapram hydrochloride

Doxepin hydrochloride

Doxercalciferol

Edetate calcium disodium

Emtricitabine

Emtricitabine-tenofovir disoproxil fumarate

Enfuvirtide

Enoxaparin sodium

Eplerenone

Epoprostenol sodium

Ertapenem

Erythromycin

Erythromycin ethylsuccinate

Erythromycin stearate

Esomeprazole magnesium

Esomeprazole sodium

Etanercept

Ethacrynate sodium

Ethacrynic acid

Etravirine

Famciclovir

Famotidine

Fenoldopam mesylate

Fondaparinux sodium

Galantamine hydrobromide

Glatiramer acetate

Glucagon

Glyburide-metformin hydrochloride

Granisetron hydrochloride

Hydrochlorothiazide

Ibuprofen

Indapamide

Infliximab

Insulin aspart

Insulin lispro (human)

Insulin lispro protamine (human)-insulin lispro

(human)

Ipratropium bromide

Iron sucrose

Isosorbide mononitrate

Lactulose

Lansoprazole

Lansoprazole-naproxen

Laronidase

Lepirudin

Levocarnitine

Levocetirizine dihydrochloride

Lidocaine

Lidocaine hydrochloride

Lidocaine-prilocaine

Lindane

Loperamide hydrochloride

Loracarbef

Loratadine

Malathion

Maraviroc

Meclizine hydrochloride

Memantine hydrochloride

Meropenem

Mesalamine

Metformin hydrochloride

Metformin hydrochloride-sitagliptin phosphate

Methohexital sodium

Methyldopa

Methylnaltrexone bromide

Metolazone

Metronidazole

Miglitol

Montelukast sodium

Mupirocin

Mupirocin calcium

Naftifine hydrochloride

Nalbuphine hydrochloride

Nalmefene hydrochloride

Naloxone hydrochloride

Naproxen sodium

Nedocromil sodium

Nelfinavir mesylate

Nitazoxanide

Nitrofurantoin macrocrystals

Nitrofurantoin macrocrystals-nitrofurantoin monohydrate

Nizatidine

Octreotide acetate

Omalizumab

Ondansetron

Ondansetron hydrochloride

Orlistat

Oxiconazole nitrate

Oxybutynin

Oxybutynin chloride

Oxycodone hydrochloride

Palonosetron hydrochloride

Pancrelipase

Pantoprazole sodium

Pegvisomant

Pemoline

Penciclovir

Penicillin G benzathine

Penicillin G benzathine-penicillin G procaine

Penicillin G potassium

Pentosan polysulfate sodium

Permethrin

Piperacillin sodium

Piperacillin sodium-tazobactam sodium

Praziquantel

Progesterone

Propofol

Pseudoephedrine hydrochloride

Pseudoephedrine sulfate

Psyllium preparations

Rabeprazole sodium

Ranitidine hydrochloride

Retapamulin

Rifabutin

Ritonavir

Rivastigmine tartrate

Ropivacaine hydrochloride

Saquinavir mesylate

Sevoflurane

Sildenafil citrate

Silver sulfadiazine

Sitagliptin phosphate

Sodium ferric gluconate

Somatropin

Sotalol hydrochloride

Sucralfate

Sulfasalazine

Tadalafil

Tamsulosin hydrochloride

Tenofovir disoproxil fumarate

Terbinafine hydrochloride

Ticarcillin disodium-clavulanate potassium

Ticlopidine hydrochloride

Tirofiban hydrochloride

Torsemide

Trastuzumab

Treprostinil sodium

Urokinase

Ursodiol

Valacyclovir hydrochloride

Vancomycin hydrochloride

Vardenafil hydrochloride

Zafirlukast

A: No Risk Shown in Controlled Studies

Adequate, well-controlled studies in pregnant women have failed to demonstrate risk to the fetus.

Liothyronine sodium

Liotrix

Nystatin

Reference

LaGow B, ed. Drug Topics Red Book. Montvale, N.J.: Thomson Healthcare; 2009.