THE APhA COMPLETE REVIEW FOR PHARMACY, 7th Ed

Appendix M: Common Drug Interactions: Cytochrome P450 Interactions

Substrates (trade name)

Inhibitors (trade name)

Inducers (trade name)

CYP1A2

   

Alosetron (Lotronex)

Amitriptyline (Elavil)

Anagrelide (Agrylin)

Aprepitant (Emend)

Caffeine

Cinacalcet (Sensipar)

Clomipramine (Anafranil)

Clozapine (Clozaril)

Cyclobenzaprine (Flexeril)

Desipramine (Norpramin)

Diazepam (Valium)

Diphenhydramine (Benadryl)

Duloxetine (Cymbalta)

Erlotinib (Tarceva)

Flutamide (Eulexin)

Fluvoxamine (Luvox)

Frovatriptan (Frova)

Gingko

Haloperidol (Haldol)

Imipramine (Tofranil)

Indiplon

Lidocaine

Melatonin

Mexiletine (Mexitil)

Mirtazapine (Remeron)

Olanzapine (Zyprexa)

Ondansetron (Zofran)

Palonosetron (Aloxi)

Pimozide (Orap)

Propranolol (Inderal)

Ramelteon (Rozerem)

Rasagiline (Azilect)

Ropinirole (Requip)

Ropivacaine (Naropin)

R-warfarin (Coumadin)

Selegiline (Eldepryl)

Tacrine (Cognex)

Tamoxifen (Nolvadex)

Theophylline, aminophylline (Aerolate, Aquaphyllin, Asmalix, Bronkodyl, Choledyl, Constant-T, Duraphyl, Elixophyllin, Phyllocontin, Quibron, Respbid, Slo-bid, Slo-Phyllin, Sustaire, Theo-24, Theobid, Theochron, Theoclear, Theo-Dur, Theolair, Theon, Theospan, Theovent, Truphylline)

Thiabendazole (Mintezol)

Tizanidine (Zanaflex)

Triamterene

Zafirlukast (Accolate)

Zileuton (Zyflo)

Zolmitriptan (Zomig)

Artemisinin

Atazanavir (Reyataz)

Cimetidine (Tagamet)

Ciprofloxacin (Cipro)

Clarithromycin (Biaxin)

Enoxacin (Penetrex)

Erythromycin (E-Mycin)

Ethinyl estradiol

Fluvoxamine (Luvox)

Grapefruit juice

Isoniazid (INH, Nydrazid)

Ketoconazole (Nizoral)

Mexiletine (Mexitil)

Norfloxacin (Chibroxin, Noroxin, Norflox)

Tacrine (Cognex)

Thiabendazole (Mintezol)

Zafirlukast (Accolate)

Zileuton (Zyflo)

Cigarette smoke

Phenobarbital (Luminal)

Rifampin (Rifadin, Rimactane)

Ritonavir (Norvir)

CYP2C9

   

Alosetron (Lotronex)

Amprenavir (Agenerase)

Azapropazone

Bosentan (Tracleer)

Candesartan (Atacand)

Celecoxib (Celebrex)

Chlorpropamide (Diabinese)

Diclofenac (Cataflam, Voltaren)

Doxepin (Sinequan)

Dronabinol (Marinol)

Fluoxetine (Prozac)

Flurbiprofen (Ansaid)

Fluvastatin (Lescol)

Glimepiride (Amaryl)

Glipizide (Glucotrol)

Glyburide (DiaBeta)

Ibuprofen (Advil, Motrin)

Indomethacin (Indocin)

Irbesartan (Avapro)

Losartan (Cozaar)

Melatonin

Meloxicam (Mobic)

Montelukast (Singulair)

Naproxen (Aleve, Naprosyn)

Nateglinide (Starlix)

Phenytoin (Dilantin)

Piroxicam (Feldene)

Ramelteon (Rozerem)

Rosiglitazone (Avandia)

Rosuvastatin (Crestor)

Sildenafil (Viagra)

Sitaxsentan

Sulfamethoxazole (Bactrim, Gantanol, Septra, Sulfatrim)

S-warfarin (Coumadin)

Tolbutamide (Orinase)

Torsemide (Demadex)

Valdecoxib (Bextra)

Valsartan (Diovan)

Voriconazole (Vfend)

Alcohol (intoxicating dose)

Amiodarone (Cordarone, Pacerone)

Benzbromarone

Cimetidine (Tagamet)

Clopidogrel (Plavix)

Delavirdine (Rescriptor)

Disulfiram (Antabuse)

Doxifluridine

Efavirenz (Sustiva)

Fluconazole (Diflucan)

Fluorouracil (5-FU)

Fluoxetine (Prozac)

Fluvastatin (Lescol)

Fluvoxamine (Luvox)

Gemfibrozil (Lopid)

Imatinib (Gleevec)

Isoniazid (INH, Nydrazid)

Leflunomide (Arava)

Metronidazole (Flagyl)

Miconazole (Monistat)

Modafinil (Provigil)

Phenytoin (Dilantin)

Sertraline (Zoloft)

Sitaxsentan

Sulfamethoxazole (Bactrim, Gantanol, Septra, Sulfatrim)

Sulfaphenazole

Sulfinpyrazone (Anturane)

Trimethoprim (Bactrim, Primsol, Proloprim, Septra, Sulfatrim, Trimpex)

Valproic Acid (Depakene)

Voriconazole (Vfend)

Zafirlukast (Accolate)

Aminoglutethimide (Cytadren)

Aprepitant (Emend)

Barbiturates

Bosentan (Tracleer)

Carbamazepine (Tegretol)

Phenobarbital (Luminal)

Rifampin (Rifadin, Rimactane)

CYP2C19

   

Aprepitant (Emend)

Aripiprazole (Abilify)

Carisoprodol (Soma)

Citalopram (Celexa)

Clomipramine (Anafranil)

Clopidogrel (Plavix)

Clozapine (Clozaril)

Desipramine (Norpramin)

Diazepam (Valium)

Diphenhydramine (Benadryl)

Doxepin (Sinequan)

Escitalopram (Lexapro)

Flunitrazepam

Fluoxetine (Prozac)

Imipramine (Tofranil)

Lansoprazole (Prevacid)

Mephenytoin (Mesantoin)

Methadone

Moclobemide (Manerix)

Nelfinavir (Viracept)

Olanzapine (Zyprexa)

Omeprazole (Prilosec)

Pantoprazole (Protonix)

Pentamidine (Pentam)

Phenobarbital

Phenytoin (Dilantin)

Proguanil (active metabolite)

Propranolol (Inderal)

Rabeprazole (Aciphex)

R-warfarin (Coumadin)

Sertraline (Zoloft)

Thalidomide (Thalomid)

Voriconazole (Vfend)

Chloramphenicol

Cimetidine (Tagamet)

Clopidogrel (Plavix)

Delavirdine (Rescriptor)

Efavirenz (Sustiva)

Felbamate (Felbatol)

Fluconazole (Diflucan)

Fluoxetine (Prozac)

Fluvastatin (Lescol)

Fluvoxamine (Luvox)

Isoniazid (INH, Nydrazid)

Ketoconazole (Nizoral)

Lansoprazole (Prevacid)

Moclobemide (Manerix)

Modafinil (Provigil)

Omeprazole (Prilosec)

Oxcarbazepine (Trileptal)

Ticlopidine (Ticlid)

Topiramate (Topamax)

Voriconazole (Vfend)

Artemisinin

Barbiturates

Carbamazepine (Tegretol)

Phenytoin (Dilantin)

Norethindrone

Rifampin (Ramactane)

St. John's wort

CYP2D6

   

Almotriptan (Axert)

Alprenolol

Amitriptyline (Elavil)

Amprenavir (Agenerase)

Atomoxetine (Strattera)

Bisoprolol (Zebeta)

Carvedilol (Coreg)

Cevimeline (Evoxac)

Chlorpheniramine

Chlorpromazine (Thorazine)

Cinacalcet (Sensipar)

Citalopram (Celexa)

Clomipramine (Anafranil)

Codeine

Cyclobenzaprine (Flexeril)

Darifenacin (Enablex)

Debrisoquin

Desipramine (Norpramin)

Dextromethorphan

Dihydrocodeine

Diphenhydramine (Benadryl)

Dolasetron (Anzemet)

Donepezil (Aricept)

Doxepin (Sinequan)

Duloxetine (Cymbalta)

Encainide

Escitalopram (Lexapro)

Flecainide (Tambocor)

Fluoxetine (Prozac)

Fluvoxamine (Luvox)

Galantamine (Reminyl)

Haloperidol (Haldol)

Hydrocodone

Imipramine (Tofranil)

Loratadine (Claritin)

Maprotiline (Ludiomil)

Methadone

Methamphetamine

Metoclopramide (Reglan)

Metoprolol (Lopressor)

Mexiletine (Mexitil)

Mianserin

Mirtazapine (Remeron)

Nortriptyline (Aventyl, Pamelor)

Olanzapine (Zyprexa)

Ondansetron (Zofran)

Oxycodone (Endocodone, OxyContin, OxyIR, Percodan, Percolone, Roxicodone)

Palonosetron (Aloxi)

Paroxetine (Paxil)

Perhexiline (Pexid)

Perphenazine (Trilafon)

Promethazine (Phenergan)

Propafenone (Rhythmol)

Propoxyphene (Darvon)

Propranolol (Inderal)

Protriptyline (Vivactil)

Ranolazine (Ranexa)

Risperidone (Risperdal)

Sertindole (Serlect)

Sertraline (Zoloft)

Simvastatin (Zocor)

Tamoxifen (Nolvadex)

Thioridazine (Mellaril)

Timolol (Betimol, Blocadren, Timoptic)

Tolterodine (Detrol)

Tramadol (Ultram)

Trazodone (Desyrel)

Venlafaxine (Effexor)

Yohimbine

Amiodarone (Cordarone, Pacerone)

Bupropion (Wellbutrin)

Chloroquine (Aralen)

Chlorpheniramine

Chlorpromazine (Thorazine)

Celecoxib (Celebrex)

Cimetidine (Tagamet)

Cinacalcet (Sensipar)

Citalopram (Celexa)

Clomipramine (Anafranil)

Diphenhydramine (Benadryl)

Duloxetine (Cymbalta)

Escitalopram (Lexapro)

Fluoxetine (Prozac)

Halofantrine (Halfan)

Haloperidol (Haldol)

Hydroxychloroquine

Imatinib (Gleevec)

Paroxetine (Paxil)

Perphenazine (Trilafon)

Promethazine (Phenergan)

Propafenone (Rhythmol)

Propoxyphene (Darvon)

Quinacrine

Quinidine (Cardioquin, Dura-Tabs, Quinaglute, Quinidex)

Quinine

Ranolazine (Ranexa)

Risperidone (Risperdal)

Ritonavir (Norvir)

Sertraline (Zoloft)

Terbinafine (Lamisil)

Thioridazine (Mellaril)

Rifampin (Rifadin, Rimactane)

CYP2E1

   

Acetaminophen (Tylenol)

Chlorzoxazone (Parafon Forte)

Ethanol, enflurane, halothane, isoflurane, methoxyflurane, sevoflurane

Theophylline, aminophylline (Aerolate, Aquaphyllin, Asmalix, Bronkodyl, Choledyl, Constant-T, Duraphyl, Elixophyllin, Phyllocontin, Quibron, Respbid, Slo-bid, Slo-Phyllin, Sustaire, Theo-24, Theobid, Theochron, Theoclear, Theo-Dur, Theolair, Theon, Theospan, Theovent, Truphylline)

Disulfiram (Antabuse)

Chronic ethanol Isoniazid (INH, Nydrazid)

CYP3A

   

Alfentanil (Alfenta)

Alfuzosin (Uroxatral)

Almotriptan (Axert)

Alosetron (Lotronex)

Alprazolam (Xanax)

Amiodarone (Cordarone)

Amitriptyline (Elavil)

Amlodipine (Norvasc)

Amprenavir (Agenerase)

Aprepitant (Emend)

Aripiprazole (Abilify)

Astemizole (Hismanal)

Atazanavir (Reyataz)

Atorvastatin (Lipitor)

Bepridil (Vascor)

Bexarotene (Targretin)

Bosentan (Tracleer)

Bromocriptine (Parlodel)

Budesonide (Entocort)

Bupivacaine (Sensorcaine)

Buprenorphine (Subutex)

Buspirone (Buspar)

Calcium channel blockers

Carbamazepine (Tegretol)

Cevimeline (Evoxac)

Chlorpheniramine

Cilostazol (Pletal)

Cinacalcet (Sensipar)

Cisapride (Propulsid)

Citalopram (Celexa)

Clarithromycin (Biaxin)

Clomipramine (Anafranil)

Clonazepam (Klonopin)

Clopidogrel (Plavix)

Clozapine (Clozaril)

Colchicine

Conivaptan (Vaprisol)

Cyclobenzaprine (Flexeril)

Cyclophosphamide (Cytoxan)

Cyclosporine (Gengraf, Neoral, Sandimmune)

Dapsone (Avlosulfon)

Darifenacin (Enablex)

Darunavir (Prezista)

Dasatinib (Sprycel)

Delavirdine (Rescriptor)

Dexamethasone (Decadron)

Dextromethorphan

Diazepam (Valium)

Diclofenac (Voltaren)

Dihydroergotamine (D.H.E. 45)

Diltiazem (Cardizem)

Disopyramide (Norpace)

Docetaxel (Taxotere)

Dolasetron (Anzemet)

Donepezil (Aricept)

Doxorubicin (Adriamycin)

Droperidol

Dutasteride (Avodart)

Ebastine (Kestine)

Efavirenz (Sustiva)

Eletriptan (Relpax)

Eplerenone (Inspra)

Ergotamine (Ergomar)

Erlotinib (Tarceva)

Erythromycin (E-Mycin)

Escitalopram (Lexapro)

Estazolam (Prosom)

Estrogens

Eszopiclone (Lunesta)

Ethosuximide (Zarontin)

Etoposide (Vepesid)

Exemestane (Aromasin)

Felodipine (Plendil)

Fentanyl (Sublimaze)

Finasteride (Proscar)

Flunitrazepam

Flurazepam (Dalmane)

Fosamprenavir (Lexiva)

Galantamine (Reminyl)

Garlic

Gefitinib (Iressa)

Gingko

Granisetron (Kytril)

Halofantrine (Halfan)

Haloperidol (Haldol)

Ifosfamide (Ifex)

Imatinib (Gleevec)

Imipramine (Tofranil)

Indiplon

Irinotecan (Camptosar)

Isradipine (DynaCirc)

Itraconazole (Sporanox)

Ivabradine

Ixabepilone (Ixempra)

Ketoconazole (Nizoral)

Lansoprazole (Prevacid)

Lapatinib (Tykerb)

Levomethadyl (Orlaam)

Lidocaine

Loperamide (Imodium)

Loratadine (Claritin)

Losartan (Cozaar)

Lovastatin (Mevacor)

Maraviroc (Selzentry)

Mefloquine (Lariam)

Meloxicam (Mobic)

Methadone

Methylprednisolone

Midazolam (Versed)

Mifepristone (Mifeprex)

Mirtazapine (Remeron)

Modafinil (Provigil)

Montelukast (Singulair)

Nateglinide (Starlix)

Nefazodone (Serzone)

Nicardipine (Cardene)

Nifedipine (Adalat)

Nimodipine (Nimotop)

Nisoldipine (Sular)

Nitrendipine (Baypress)

Omeprazole (Prilosec)

Ondansetron (Zofran)

Oxybutynin (Ditropan)

Oxycodone (Percodan)

Amiodarone (Cordarone, Pacerone)

Amprenavir (Agenerase)

Aprepitant (Emend)

Aripiprazole (Abilify)

Atazanavir (Reyataz)

Chloramphenicol

Cimetidine (Tagamet)

Clarithromycin (Biaxin)

Conivaptan (Vaprisol)

Cyclosporine (Neoral)

Danazol (Danocrine)

Darunavir (Prezista)

Dasatinib (Sprycel)

Delavirdine (Rescriptor)

Diltiazem (Cardizem)

Erythromycin (E-Mycin)

Estrogens

Fluconazole (Diflucan)

Fluoxetine (Prozac)

Fluvoxamine (Luvox)

Fosamprenavir (Lexiva)

Grapefruit juice

Imatinib (Gleevec)

Indinavir (Crixivan)

Interleukin-10

Isoniazid (INH, Nydrazid)

Itraconazole (Sporanox)

Ketoconazole (Nizoral)

Lapatinib (Tykerb)

Miconazole (Monistat)

Mifepristone (Mifeprex)

Nefazodone (Serzone)

Nelfinavir (Viracept)

Nicardipine (Cardene)

Norfloxacin (Chibroxin, Noroxin)

Posaconazole (Noxafil)

Propoxyphene (Darvon)

Quinupristin (Synercid)

Ranolazine (Ranexa)

Ritonavir (Norvir)

Saquinavir (Fortovase, Invirase)

Tamoxifen (Nolvadex)

Telithromycin (Ketek)

Troleandomycin (TAO)

Verapamil (Calan)

Voriconazole (Vfend)

Zafirlukast (Accolate)

Aminoglutethimide (Cytadren)

Barbiturates

Bexarotene (Targretin)

Bosentan (Tracleer)

Carbamazepine (Tegretol)

Dexamethasone (Decadron)

Efavirenz (Sustiva)

Glucocorticoids

Griseofulvin (Grisactin)

Modafinil (Provigil)

Nafcillin (Unipen)

Nevirapine (Viramune)

Oxcarbazepine (Trileptal)

Phenobarbital (Luminal)

Phenytoin (Dilantin)

Primidone (Mysoline)

Rifabutin (Mycobutin)

Rifampin (Rifadin, Rimactane)

St. John's wort

Topiramate (Topamax)

Paclitaxel (Taxol)

Palonosetron (Aloxi)

Pantoprazole (Protonix)

Paricalcitol (Zemplar)

Pimozide (Orap)

Pioglitazone (Actos)

Praziquantel (Biltricide)

Prednisolone

Prednisone

Propoxyphene (Darvon)

Protease inhibitors

Quazepam (Doral)

Quetiapine (Seroquel)

Quinacrine

Quinidine (Cardioquin, Quinaglute, Quinidex)

Quinine

Ramelteon (Rozerem)

Ranolazine (Ranexa)

Repaglinide (Prandin)

Rifabutin (Mycobutin)

Risperidone (Risperdal)

Ritonavir (Norvir)

Ropivacaine (Naropin)

R-warfarin (Coumadin)

Selegiline (Eldepryl)

Sertindole (Serlect)

Sertraline (Zoloft)

Sibutramine (Meridia)

Sildenafil (Viagra)

Simvastatin (Zocor)

Sirolimus (Rapammune)

Sitaxsentan

   

Solifenacin (Vesicare)

Sufentanil (Sufenta)

Sulfamethoxazole (Bactrim)

Sunitinib (Sutent)

Tacrolimus (Prograf)

Tadalafil (Cialis)

Tamoxifen (Nolvadex)

Tamsulosin (Flomax)

Teniposide (Vumon)

Terfenadine

Testosterone

Theophylline

Tiagabine (Gabitril)

Tinidazole (Tindamax)

Tipranavir (Aptivus)

Tolterodine (Detrol)

Topiramate (Topamax)

Tramadol (Ultram)

Trazodone (Desyrel)

Triamterene

Triazolam (Halcion)

Valdecoxib (Bextra)

Vardenafil (Levitra)

Venlafaxine (Effexor)

Verapamil (Calan)

Vesnarinone

Vinblastine (Velbane)

Vincristine (Oncovin)

Voriconazole (Vfend)

Yohimbine

Ziprasidone (Geodon)

Zolpidem (Ambien)

Zonisamide (Zonegran)

Zopiclone (Imovane)

   

References

Hansten PD, Horn JR. The Top 100 Drug Interactions. Freeland, Wash.: H&H Publications; 2008. Micromedex Healthcare Series. Greenwood Village, Colo.: Thomson Healthcare. Available at: www.thomsonhc.com. Updated periodically.