Top 300 Pharmacy Drug Cards

Preface A: Anatomy of a Flash Card

Medication Name

Both generic and common brand names are listed.


Medications are grouped into classes (“families”) based on their chemical, pharmacological, or clinical properties. It is often useful to study medications on a class-by-class basis, identifying similarities and differences amongst members of each class.

Controlled Substance Schedule

Title 21 of the United States Code (USC) is the Controlled Substances Act of 1970. It regulates medications with potential for abuse. These Federal regulations are overseen by the Drug Enforcement Administration, but many States have enacted more strict regulations based on them. Medications are placed into schedules based on their clinical use and their risk of abuse and dependence. It is important to note that some States change the Federal scheduling of certain medications. Under Federal law, a State cannot place a medication in a lower schedule than where it is placed by the Federal government (eg, States cannot change a drug placed in Federal Schedule II to Schedule III, IV, or V), but States can and do place certain medications in higher schedules (eg, changing a drug placed in Federal Schedule V into Schedule II, III, or IV, or changing a drug which is not a controlled substance under Federal law into a controlled substance within that State).

• Schedule I: No medical use, high abuse, and dependence potential.

• Schedule II: Legitimate medical use, high abuse, and dependence potential.

• Schedule III: Legitimate medical use, abuse, and dependence potential somewhat less than Schedule II.

• Schedule IV: Legitimate medical use, abuse, and dependence potential less than Schedule III.

• Schedule V: Legitimate medical use, limited abuse, and dependence potential.

Dosage Forms

The most common dosage forms and strengths are listed. Other dosage forms may exist, and may be referenced in the Clinical Pearls section.

Common FDA Label Indication and Dosing

The US Food and Drug Administration (FDA) approves medications for market, and also approves specific indications for use and the doses for those uses. Some medications are approved for only one indication, while others are approved for many indications. In most cases, all FDA-approved (“labeled”) indications are listed with their approved doses.

Off-Label Uses

While every medication must be approved by the FDA for at least one indication before it is marketed, FDA approval is not always sought for subsequent indications. Prescribers are legally entitled to prescribe medications for any indication they feel is appropriate and clinically justified. In most cases, prescribers limit their use of medications to indications for which evidence supports safety and efficacy, as demonstrated in published clinical trials. While these may not be FDA-approved indications, “off-label” use is common and often completely appropriate. Common off-label uses are included, along with dosing recommendations.

MOA (Mechanism of Action)

The MOA is a succinct summary of the pharmacological properties of each medication.

Drug Characteristics

Each card includes a table summarizing key drug parameters, as outlined below.

Dose Adjustments Hepatic

A Child-Pugh Score can be used to assess hepatic dysfunction. The score employs five clinical measures of liver disease. Each is scored 1-3, with 3 indicating the most severe derangement of that measure. Based on the number of points for each measure, liver disease can be classified into Child-Pugh class A, B, or C.



Dose Adjustments Renal

Dose adjustments for some (but not all) of medications that are renally eliminated are necessary in patients with renal dysfunction and hepatically eliminated medications in patients with hepatic dysfunction. Dose adjustments are made by either lowering the dose or dosing less frequently (eg, reducing from tid to daily dosing). The degree of renal dysfunction usually determines the degree of the dose adjustment. Definitions of renal and hepatic dysfunction are often inconsistent, but the recommended dose adjustments included in these flash cards are drawn from product package inserts and other sources. Clinicians should always exercise caution when treating patients with liver and/or kidney disease, and monitor carefully for signs of toxicity, even if dose adjustments are made.

In general, CrCl is used to assess renal function and is calculated with the following equations:

Cockcroft and Gault Equation:

CrCl (males) = [(140 – age) × IBW]/(Scr × 72)

CrCl (females) = [(140 – age) × IBW]/(Scr × 72) × (0.85)

Estimate Ideal Body Weight in (kg):

Males: IBW = 50 kg + 2.3 kg for each inch over 5 ft

Females: IBW = 45.5 kg + 2.3 kg for each inch over 5 ft

Normal Renal Function: CrCl = 50 mL/min or greater

Moderate Renal Impairment: CrCl = 30-50 mL/min

Severe Renal Impairment: CrCl =10-29 mL/min

Renal Failure: CrCl = 9 mL/min or less


Medications may be removed by peritoneal or hemodialysis, requiring dose adjustments and/or re-dosing after dialysis to replace drug lost. Many references provide details regarding the dialyzability of drugs, and these cards provide basic adjustment recommendations.

Pregnancy Category

The US Food and Drug Administration rate and categorize medications based on the level of risk of fetal harm that medications pose when taken by pregnant women. While these categories are discrete, it is important to recognize that they are sometimes set on the basis of theoretical risks. Clinical decisions must be made individually, weighing the potential risk to both the pregnant woman and the fetus. The pregnancy category of each medication is provided.

• Category A: Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).

• Category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

• Category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

• Category D: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

• Category X: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

As with pregnancy categories, relatively little evidence is available to guide clinical decision making regarding the use of medications in women who are breast feeding. In most cases, the risks to the child must be weighed against the benefits to the breast-feeding mother. In general, this assessment is based on the risk that an individual medication will be expressed in breast milk, and the risk that such an expression would cause to the infant who subsequently ingests it.


Some medications should never be used in certain circumstances or under certain conditions. These situations are known as contraindications and are usually related to common and very dangerous adverse effects that must be avoided by selecting alternative therapeutic options.


Pharmacokinetic parameters related to oral bioavailability (F) and the impact of food on absorption are provided.


Pharmacokinetic data on extent and nature of distribution, including volume of distribution (Vd) and the extent of protein binding, are provided.


Pharmacokinetic data on metabolic pathways, including cytochrome P450 pathway of elimination, and whether a drug is an enzyme inducer or inhibitor, are provided.


Pharmacokinetic data on extent of renal (or other) elimination, as well as elimination half-life, are provided.


Pharmacogenetic information is included if the drug has pharmacogenetic information in the drug label. Generally, information is provided when a patient’s genetic composition can affect drug exposure and clinical response variability, risk for adverse events, genotype-specific dosing, or mechanism of drug action. A complete list of drugs with pharmacogenetic information can be found at the following website:

Black Box Warnings

The US Food and Drug Administration requires manufacturers to list certain significant safety-related concerns in boxed warnings in their approved product package inserts. These “black box warnings” contain critical information for the safe use of those medications. Key black box warning content is included on each card. Additional information on black box warnings can be found at the following website:

Medication Safety Issues

Each card includes a table summarizing key medication safety concerns, as outlined below.


Many products are available in multiple formulations, for example, in delayed-release dosage forms. These dosage forms are often distinguished through the use of suffixes appended to the name of a different formulation of that same product. It is essential to exercise caution to avoid errors caused by confusing one product with another by omitting or not recognizing the additional suffix. Products that are available in multiple formulations, distinguished by a suffix (or occasionally, a prefix), are noted in this field.

“Tall Man” Letters

Many medications are spelled similarly, leading to substitution errors during prescribing, dispensing or administration. The use of “Tall Man” lettering—distinguishing one medication from a different, similarly named medication, by capitalizing specific portions of the medication name (either brand or generic name)—has been shown to help prevent substitution errors. Those products for which Tall Man lettering is recommended are noted in this field.

Do Not Crush

Many solid oral dosage formulations are developed to release their active ingredient slowly over time. Crushing those dosage forms (eg, to enable administration through a nasogastric tube, or to make easier to swallow by patients with swallowing disorders) may be particularly dangerous. The formulations of certain products that should not be crushed are noted in this field. Sublingual dosage forms are meant to be dissolved under the tongue and swallowing these dosage forms without allowing them to dissolve lowers the efficacy of the drug. Some taste really bad, and patients prefer to swallow them without allowing them to dissolve.

High Alert

The Institute for Safe Medication Practices (ISMP) maintains a list of medications that are often involved in medication errors, or that are associated with a heightened risk of causing significant patient harm when used in error. Specific care must be exercised when prescribing, dispensing, or administering these products. More information on this field can be found at the ISMP website at

Confused Names

Many medications are confused with other medications based on similarities in the spelling or pronunciation of their names, resulting in substitution errors. Those products that may be confused with different “look-alike or sound-alike” products are noted in this field.

Drug Interactions

Concurrent use of multiple medications (poly-pharmacy) introduces significant risks as certain drugs interact with others to create adverse effects. Many interactions are caused when one agent affects the metabolism of another, thereby either increasing the risk of toxicity (when metabolism is decreased) or decreasing efficacy (when metabolism is increased). Examples of drugs that are inhibitors or inducers of the cytochrome P450 system, or are substrates (drugs metabolized by that system), and other metabolic issues, are included in Prefaces H, I, J, and K. Other mechanisms can also result in negative outcomes. The most common interactions are listed in these cards. Note that in many cases, drugs interact in a similar way with entire classes of other drugs, and in those situations, the class of interacting agent is listed. Lists of the agents that are members of those classes are listed in other prefaces in this card set. Since some interactions are unavoidable, strategies for managing some interactions are provided.

Adverse Reactions

Every drug is associated with potential risks. Adverse effects are evaluated based on the frequency with which they occur and the degree of severity of the reaction, if it does occur. Most medications have a few common adverse effects that may or may not be severe enough to limit the use of the medication, and a few that occur rarely, but are very serious. Common adverse effects (that occur in >10% of patients who take the medication) and less common (that occur in 1-10% of patients) are summarized in these cards. Rare (occurring in <1% of patients) but serious adverse effects are also listed.

Monitoring Parameters—Efficacy and Toxicity

Patients receiving medications should be monitored to ensure that the treatment is achieving its desired outcome without causing adverse effects. Specific efficacy and toxicity monitoring parameters are listed for each medication.

Key Patient Counseling Points

In order for medications to be used effectively and safely, patients must understand their therapies. Key information that patients should be provided with is summarized for each medication.

Clinical Pearls

Clinical information regarding the use of each medication is provided in this section. Special alerts from the FDA, which are usually related to adverse reactions that are being evaluated and have not been included in the product package insert, are included here as well.



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