Top 300 Pharmacy Drug Cards

Preface J: Drugs That Affect Cardiac Rhythm

Drugs that are generally accepted to prolong the QT interval and have an increased risk of torsades de pointes

Amiodarone, arsenic trioxide, astemizole, bepridil, chloroquine, chlorpromazine, cisapride, clarithromycin, disopyramide, dofetilide, domperidone, droperidol, erythromycin, halofantrine, haloperidol, ibutilide, levomethadyl, mesoridazine, methadone, pentamidine, pimozide, probucol, procainamide, quinidine, sotalol, sparfloxacin, terfenadine, thioridazine

Drugs that may prolong the QT interval and have an increased risk of torsades de pointes

Alfuzosin, amantadine, atazanavir, chloral hydrate, clozapine, dolasetron, dronedarone, escitalopram, felbamate, flecainaide, foscarnet, gatifloxacin, gemifloxacin, granisetron, indapamide, isradipine, lapatinib, levofloxacin, lithium, moxifloxacin, nicardipine, nilotinib, octreotide, ofloxacin, oxytocin, paliperidone, quetiapine, ranolazine, risperidone, sertindole, sunitinib, tacrolimus, tamoxifen, telithromycin, tizanidine, vardenafil, venlafaxine, voriconazole, ziprasidone

Drugs that prolong the PR interval

Acetylcholinesterase inhibitors (donepezil, rivastigmine, galantamine), adenosine, alendronate, anti-arrhythmics (flecainide, propafenone, procainamide), beta blockers, calcium channel blockers, digoxin, dolasetron, lithium, HIV protease inhibitors, TCAs, pregabalin, lacosamide, methyldopa, vitamin D and derivatives

Drugs that shorten the PR interval

Atropine, ibutilide