Top 300 Pharmacy Drug Cards

ENTECAVIR: Baraclude

Class: Antiretroviral Agent, Reverse Transcriptase Inhibitor

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Dosage Forms. Tablet: 0.5 mg, 1 mg; Solution: 0.5 mg/1 mL

Common FDA Label Indication, Dosing, and Titration.

1. Treatment of chronic hepatitis B virus (HBV) infection: Adults, 0.5-1 mg po daily

Off-Label Uses.

1. HBV reinfection prophylaxis: Adults, 0.5-1 mg po daily

MOA. Intracellularly phosphorylated to guanosine triphosphate which competes with natural substrates to effectively inhibit hepatitis B viral polymerase; enzyme inhibition blocks reverse transcriptase activity thereby reducing viral DNA synthesis.

Drug Characteristics: Entecavir

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Medication Safety Issues: Entecavir

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Drug Interactions: Entecavir

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Adverse Reactions: Entecavir

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Efficacy Monitoring Parameters. Hepatitis B virus DNA, LFTs.

Toxicity Monitoring Parameters. HIV status (prior to initiation of therapy); LFTs, renal function. Call healthcare provider for dark urine or yellow skin or eyes.

Key Patient Counseling Points. Complete full course of therapy; take on an empty stomach.

Clinical Pearls. Hepatitis may get worse if this drug is stopped; monitor HBV DNA after discontinuation. Consider genetic testing of HBV if suboptimal response to therapy.