Top 300 Pharmacy Drug Cards

FIDAXOMICIN: Dificid

Class: Macrolide Antibiotic

Dosage Forms. Tablet: 200 mg

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Common FDA Label Indication, Dosing, and Titration.

1. Clostridium difficile infection: 200 mg po bid × 10 d

Off-Label Uses. None

MOA. Fidaxomicin is an antibacterial agent that acts locally in the gastrointestinal tract on Clostridium difficile via inhibition of RNA polymerases.

Drug Characteristics: Fidaxomicin

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Medication Safety Issues: Fidaxomicin

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Drug Interactions: Fidaxomicin. None

Adverse Reactions: Fidaxomicin

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Efficacy Monitoring Parameters. Resolution of symptoms of Clostridium difficile infection, including resolution of diarrhea, vomiting.

Toxicity Monitoring Parameters. Monitor for signs of bowel obstruction and blood in the stool.

Key Patient Counseling Points. May be given with or without food.

Clinical Pearls. Expensive alternative to oral vancomycin for management of Clostridium difficile-associated diarrhea.