Class: Fluoroquinolone Antibiotic
Dosage Forms. Ophthalmic Solution: 0.3%, 0.5%
Common FDA Label Indication, Dosing, and Titration.
1. Bacterial conjunctivitis: Adults and Children >1 y of age, 0.3% solution, 1 drop to affected eye(s) q2h while awake × 2 d, then qid × 5 d; 0.5% ophthalmic solution, 1 drop to affected eye(s) q2h while awake × 1 d, then bid-qid × 6 d
Other Uses. None
MOA. Gatifloxacin is a fluoroquinolone that inhibits bacterial topoisomerase II and IV. It is highly active against aerobic, Gram-negative bacilli, especially Enterobacteriaceae. It has poor activity against streptococci and anaerobes.
Drug Characteristics: Gatifloxacin Ophthalmic
Medication Safety Issues: Gatifloxacin Ophthalmic
Drug Interactions: Gatifloxacin Ophthalmic. None known
Adverse Reactions: Gatifloxacin Ophthalmic
Efficacy Monitoring Parameters. Resolution of signs and symptoms of eye infection.
Toxicity Monitoring Parameters. Severe eye pain, itching, redness, or burning.
Key Patient Counseling Points. Complete full course of therapy. Symptoms should improve within 2-3 d; if they worsen, seek follow-up with healthcare practitioner. Wash hands with soap and water before and after use. Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket. Hold the dropper close to your eye, but not touching, with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 min. Do not rinse or wipe the dropper or allow it to touch anything, including your eye.
Clinical Pearls. Bacterial conjunctivitis is very contagious and spread by direct contact.