Top 300 Pharmacy Drug Cards

INSULIN GLARGINE: Lantus

Class: Insulin, Long-Acting

Dosage Forms. Injection Solution: 100 units/mL

Image

Common FDA Label Indication, Dosing, and Titration.

1. Diabetes mellitus, Type I and II: Dosing is individualized to patient needs

Off-Label Uses. None

MOA. Insulin promotes cellular uptake of glucose, fatty acids, and amino acids and their conversion to glycogen, triglycerides, and proteins.

Drug Characteristics: Insulin Glargine

Image

Medication Safety Issues: Insulin Glargine

Image

Drug Interactions: Insulin Glargine

Image

Adverse Reactions: Insulin Glargine

Image

Efficacy Monitoring Parameters. Preprandial blood glucose between 70 and 130 mg/dL, HbA 1c<7%.

Toxicity Monitoring Parameters. Symptoms of hypoglycemia include nausea, sweating, and loss of consciousness.

Key Patient Counseling Points. Monitor blood glucose in frequent intervals (2-4 times per day); if <70 mg/dL, eat candy or sugar and contact prescriber. Store in refrigerator. Dispose needles in sharps container. Do not share needles; this increases the risk of transmission of infectious diseases. Rotate injection sites.

Clinical Pearls. Insulin requirements may change during periods of stress (illness) or with increased activity; monitor and adjust. Following subcutaneous administration, insulin glargine forms a microprecipitate in the fatty tissue from which small amounts of insulin are released slowly, resulting in a relatively constant concentration/time profile over 24 h with no pronounced peak.