Top 300 Pharmacy Drug Cards

ALBENDAZOLE: Albenza

Class: Anthelmintic

Dosage Forms. Tablet: 200 mg

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Common FDA Label Indication, Dosing, and Titration.

1. Parenchymal neurocysticercosis caused by Taenia solium: Adults ≥60 kg, 800 mg/d in 2 divided doses × 8-30 d; Children <60 kg: 15 mg/kg/d (max 800 mg/d) in 2 divided doses × 8-30 d

2. Cystic hydatid disease of the liver, lung, and peritoneum caused by Echinococcus granulosus: Adults ≥60 kg, 800 mg/d in 2 divided doses × 8-30 d; Children <60 kg: 15 mg/kg/d (max 800 mg/d) in 2 divided doses × 8-30 d

Off-Label Uses.

1. Ancylostoma caninumAscaris lumbricoides (roundworm), Ancylostoma duodenale (hookworm), and Necator americanus (hookworm): 400 mg po as a single dose

2. Enterobius vermicularis (pinworm): 400 mg po as a single dose, repeat in 2 wk

3. Giardia duodenalis (giardiasis): 400 mg po once daily × 5 d

MOA. Selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae

Drug Characteristics: Albendazole

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Medication Safety Issues: Albendazole

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Drug Interactions: Albendazole

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Adverse Reactions: Albendazole

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Efficacy Monitoring Parameters. Monitor fecal specimens for ova and parasites for 3 wk after treatment; if positive, retreat. Opthalmic exam in those with neurocysticercosis.

Toxicity Monitoring Parameters. LFTs and CBC and beginning of each 28-d cycle and every 2 wk. Negative pregnancy test prior to starting therapy.

Key Patient Counseling Points. Complete full course of therapy; administer with high-fat meals or grapefruit juice.

Clinical Pearls. Single dose therapy makes this agent a treatment of choice for nematode infections. Neurocysticercosis: Use concurrent corticosteroids to minimize inflammatory reactions and anticonvulsant therapy to prevent seizures. Echinococcosis: More effective than mebendazole, so may be treatment of choice.