Class: Prostaglandin, Antiglaucoma Agent
Dosage Forms. Ophthalmic Solution: 0.005%
Common FDA Label Indication, Dosing, and Titration.
1. Ocular hypertension, open-angle glaucoma: 1 drop in affected eye(s) daily in the evening
Off-Label Uses. None
MOA. Latanoprost is a prostaglandin F2-alpha analog. It is believed to reduce intraocular pressure by increasing the outflow of aqueous humor. Studies suggest that the main mechanism of action is increased uveoscleral outflow, but the exact mechanism is unknown.
Drug Characteristics: Latanoprost
Medication Safety Issues: Latanoprost
Drug Interactions: Latanoprost
Adverse Reactions: Latanoprost
Efficacy Monitoring Parameters. Reduction in intraocular pressure.
Toxicity Monitoring Parameters. Seek medical attention if symptoms of ocular irritation are severe.
Key Patient Counseling Points. Wash hands and remove contact lenses before using the medicine. For administration, lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket. Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 min. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away.
Clinical Pearls. If used concurrently with pilocarpine, separate dose by 1 h if possible. Separate administration from other ophthalmic products by at least 5 min. Advise patients that there is a risk of permanent increased iris pigmentation associated with instillation of this product. Do not administer more than once daily to avoid loss of therapeutic effect.