Dosage Forms. Oral Solution: 0.5 mg/mL; Tablet: 5 mg
Common FDA Label Indication, Dosing, and Titration.
1. Idiopathic urticaria, perennial or seasonal allergic rhinitis: Children 6 mo to 5 y of age: 1.25 mg po daily; Children 6-11 y of age: 2.5 mg po daily; Children 12 y of age and older and Adults: 5 mg po daily; doses should be given in the evening
Off-Label Uses. None
MOA. Levocetirizine, an enantiomer of cetirizine, is a low-sedating, long-acting H1-receptor antagonist that is a metabolite of hydroxyzine. It competitively inhibits the interaction of histamine with H1 receptors, thereby preventing the allergic response.
Drug Characteristics: Levocetirizine
Medication Safety Issues: Levocetirizine
Drug Interactions: Levocetirizine
Adverse Reactions: Levocetirizine
Efficacy Monitoring Parameters. Improvement in rhinitis or urticaria symptoms.
Toxicity Monitoring Parameters. Seek medical attention for signs of severe CNS toxicity; monitor SCr.
Key Patient Counseling Points. Patients should avoid activities requiring mental alertness or coordination until drug effects are known, as drug may cause dizziness or sedative effects.
Clinical Pearls. An expensive alternative to racemic version (cetirizine) which is available generically and over the counter. Limited evidence suggesting any advantage over racemic compound.