Class: Fluoroquinolone Antibiotic
Dosage Forms. Ophthalmic Solution: 0.5%
Common FDA Label Indication and Dosing.
1. Bacterial conjunctivitis: (0.5% ophthalmic solution): Adults and Children >1 y of age, 1 drop to affected eye(s) tid × 7 d
Off-Label Uses. None
MOA. Moxifloxacin is a fluoroquinolone that inhibits bacterial topoisomerase II and IV. It is highly active against aerobic, Gram-negative bacilli, especially Enterobacteriaceae.
Drug Characteristics: Moxifloxacin Ophthalmic
Medication Safety Issues: Moxifloxacin Ophthalmic
Drug Interactions: Moxifloxacin Ophthalmic. None known
Adverse Reactions: Moxifloxacin Ophthalmic
Efficacy Monitoring Parameters. Resolution of signs and symptoms of infection.
Toxicity Monitoring Parameters. Seek medical attention if severe eye pain, itching, redness, or burning.
Key Patient Counseling Points. Symptoms should improve within 2-3 d, but complete full course of therapy. If symptoms worsen, seek follow-up with healthcare practitioner. Wash hands with soap and water before and after use. Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket. Hold the dropper close to your eye, but not touching, with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 min. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Contact lenses should not be worn during therapy.
Clinical Pearls. Bacterial conjunctivitis is very contagious and spreads by direct contact.