Class: Topical Antibacterial
Dosage Forms. Topical Ointment: 2%; Topical Cream: 2%
Common FDA Label Indication and Dosing.
1. Impetigo: Apply topically tid × 3-5 d, reevaluate if no response
1. Skin infections secondary to burn: Apply topically bid × 3-5 d, reevaluate if no response
2. Superficial skin infections: Apply topically tid × 3-5 d, reevaluate if no response
MOA. Mupirocin is an antibacterial agent active against a wide range of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus. It is also active against certain Gram-negative bacteria. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. Due to this unique mode of action, mupirocin demonstrates no in vitro cross-resistance with other classes of antimicrobial agents.
Drug Characteristics: Mupirocin
Medication Safety Issues: Mupirocin
Drug Interactions: Mupirocin. None known
Adverse Reactions: Mupirocin
Efficacy Monitoring Parameters. Resolution of clinical signs of infection within 3-5 d.
Toxicity Monitoring Parameters. Seek medical attention if local adverse effects are severe.
Key Patient Counseling Points. Instruct patients on proper application technique. Avoid drug exposure to open wounds, burns, or eyes.
Clinical Pearls. The area treated may be covered with gauze dressing if desired.