Top 300 Pharmacy Drug Cards

MUPIROCIN: Bactroban, Various

Class: Topical Antibacterial

Dosage Forms. Topical Ointment: 2%; Topical Cream: 2%

Image

Common FDA Label Indication and Dosing.

1. Impetigo: Apply topically tid × 3-5 d, reevaluate if no response

Off-Label Uses.

1. Skin infections secondary to burn: Apply topically bid × 3-5 d, reevaluate if no response

2. Superficial skin infections: Apply topically tid × 3-5 d, reevaluate if no response

MOA. Mupirocin is an antibacterial agent active against a wide range of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus. It is also active against certain Gram-negative bacteria. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. Due to this unique mode of action, mupirocin demonstrates no in vitro cross-resistance with other classes of antimicrobial agents.

Drug Characteristics: Mupirocin

Image

Medication Safety Issues: Mupirocin

Image

Drug Interactions: Mupirocin. None known

Adverse Reactions: Mupirocin

Image

Efficacy Monitoring Parameters. Resolution of clinical signs of infection within 3-5 d.

Toxicity Monitoring Parameters. Seek medical attention if local adverse effects are severe.

Key Patient Counseling Points. Instruct patients on proper application technique. Avoid drug exposure to open wounds, burns, or eyes.

Clinical Pearls. The area treated may be covered with gauze dressing if desired.