Top 300 Pharmacy Drug Cards

NABUMETONE: Relafen, Various

Class: NSAID

Dosage Forms. Tablet: 500 mg, 750 mg


Common FDA Label Indication, Dosing, and Titration.

1. Osteoarthritis: 1000-2000 mg po daily or bid

2. Rheumatoid arthritis: 1000-2000 mg po daily or bid

Off-Label Uses.

1. Soft tissue injury: 1000-2000 mg po daily or bid

MOA. Nabumetone is a prodrug, biotransformed into 6-methoxy-2-naphthylacetic acid (6MNA), a nonselective inhibitor of cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2), and reversibly alters platelet function and prolongs bleeding time.

Drug Characteristics: Nabumetone


Medication Safety Issues: Nabumetone


Drug Interactions: Nabumetone


Adverse Reactions: Nabumetone


Efficacy Monitoring Parameters. Decreased pain and improved range of motion.

Toxicity Monitoring Parameters. Severe skin rash, black tarry stools, chest pains, yellowing of eyes or skin, change in urination; monitor CBC, LFTs, SCr, fecal occult blood tests if chronic use.

Key Patient Counseling Points. Take with food or milk to decrease GI upset.

Clinical Pearls. Elderly patients are at increased risk of GI ulceration. Patients with underlying cardiac dysfunction are at increased risk of cardiovascular effects. Use lowest dose for shortest period of time to minimize toxicity.

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