Top 300 Pharmacy Drug Cards

OLOPATADINE: Patanol

Class: Ophthalmic Antihistamine

Dosage Forms. Ophthalmic Solution: 0.1%, 0.2%

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Common FDA Label Indication, Dosing, and Titration.

1. Allergic conjunctivitis: 1 drop of 0.1% solution in affected eye bid or 1 drop of 0.2% solution in affected eyes daily

Off-Label Uses. None

MOA. Olopatadine hydrochloride is a relatively selective histamine H1-antagonist that exerts its effect by inhibiting the release of histamine from mast cells. It also blocks the type 1 immediate hypersensitivity reactions including prevention of histamine-mediated effects on human conjunctival epithelial cells. It has no activity on dopamine, alpha-adrenergic, and muscarinic type 1 and type 2 receptors.

Drug Characteristics: Olopatadine

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Medication Safety Issues: Olopatadine

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Drug Interactions: Olopatadine. None known

Adverse Reactions: Olopatadine

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Efficacy Monitoring Parameters. Reduction in ocular redness, itching, and irritation.

Toxicity Monitoring Parameters. Signs of hypersensitivity.

Key Patient Counseling Points. Wash hands and remove contact lenses before using the medicine. For administration, lie down or tilt head back. With index finger, pull down the lower lid of eye to form a pocket. Hold the dropper close to eye with the other hand. Drop the correct number of drops into the pocket made between lower lid and eyeball. Gently close eyes. Place index finger over the inner corner of your eye for 1 min. Do not rinse or wipe the dropper or allow it to touch anything, including eye. Put the cap on the bottle right away.

Clinical Pearls. Efficacy and safety established for patients 3 y of age and older. Also available in nasal formulation.