Top 300 Pharmacy Drug Cards

PAROXETINE: Paxil, Paxil CR, Various

Class: SSRI Antidepressant

Dosage Forms. Tablet: 10 mg, 20 mg, 30 mg, 40 mg; Tablet (Controlled Release): 12.5 mg, 25 mg, 37.5 mg; Solution, Syrup: 10 mg/5 mL; Suspension: 10 mg/5mL


Common FDA Label Indication, Dosing, and Titration.

1. Depression: Adults, immediate release, 20 mg po daily, titrate to 50 mg po daily; Adults, controlled release, 12.5 mg po daily, titrate to 62.5 mg po daily; Children 8 y and older, 10-20 mg po daily

2. OCD: Adults, 20 mg po daily, titrate to 60 mg po daily; Children, 8 y of age and older, 10 mg po daily, titrate to 30 mg daily

3. Panic disorder: Immediate release, 10 mg po daily, titrate to 60 mg po daily; Controlled release, 12.5 mg po daily, titrate to 75 mg po daily

4. Premenstrual dysphoric disorder: 12.5 mg po daily or for 14 d prior to expected start of menses, titrate to 25 mg po daily

Off-Label Uses. None

MOA. Paroxetine is a highly selective and potent inhibitor of serotonin reuptake (an SSRI) similar to fluoxetine.

Drug Characteristics: Paroxetine


Medication Safety Issues: Paroxetine


Drug Interactions: Paroxetine


Adverse Reactions: Paroxetine


Efficacy Monitoring Parameters. Improvement in symptoms of depression, panic disorder, OCD, premenstrual syndrome.

Toxicity Monitoring Parameters. Worsening of depression, suicidality, or unusual changes in behavior, especially at the initiation of therapy or with dosage increases or decreases; signs/symptoms of abnormal bleeding.

Key Patient Counseling Points. Do not chew or crush controlled-release tablet. Shake suspension well before using. Avoid activities requiring mental alertness or coordination until drug effects are realized. Symptomatic improvement may not be seen for several weeks. Avoid abrupt discontinuation. Do not drink alcohol or use NSAIDs or aspirin while taking this drug.

Clinical Pearls. If intolerable withdrawal symptoms occur following a decrease in dose or therapy discontinuation, may need to resume the previous dose and taper at a more gradual rate.

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