Top 300 Pharmacy Drug Cards


Class: Urinary Analgesic

Dosage Forms: Capsule: 100 mg


Common FDA Label Indication, Dosing, and Titration.

1. Pain relief from interstitial nephritis: 100 mg po tid

Off-Label Uses. None

MOA. Pentosan is a low-molecular-weight heparin-like compound. It has anticoagulant and fibrinolytic effects. The mechanism of action of pentosan in relieving pain associated with interstitial cystitis is not known, but it has been found to adhere to the mucosal membrane of the bladder wall and may act as a buffer to control cell permeability, which prevents irritating solutes in urine from reaching the cells.

Drug Characteristics: Pentosan


Medication Safety Issues: Pentosan


Drug Interactions: Pentosan


Adverse Reactions: Pentosan


Efficacy Monitoring Parameters. Resolution of signs and symptoms of interstitial nephritis, including nocturia, urinary pain, urinary frequency, or urinary urgency.

Toxicity Monitoring Parameters. Pentosan is a low-molecular-weight heparin-like product, so monitor for bleeding complications.

Key Patient Counseling Points. Take 1 h before or 2 h after meals. Avoid NSAIDs or aspirin-containing products.

Clinical Pearls. Patients should be evaluated after 3 mo, and if treatment has not provided benefit a second 3-mo trial may be attempted (provided no adverse effects have occurred). If the patient does not respond after 6 mo, the product is not likely to provide benefit.

If you find an error or have any questions, please email us at Thank you!