Class: Calcium Channel Blocker
Dosage Forms. Tablet: 2.5 mg, 5 mg, 10 mg
Common FDA Label Indication, Dosing, and Titration.
1. Hypertension: Children 6-17 y of age, 2.5-5 mg po daily; Adults, 5-10 mg po daily
2. Stable angina: 5-10 mg po daily
3. Variant angina: 5-10 mg po daily
1. Diabetic nephropathy: 5-15 mg po daily
2. Left ventricular hypertrophy: 5-10 mg po daily
3. Raynaud phenomenon: 10 mg po daily
MOA. Amlodipine is a dihydropyridine calcium-channel-blocking drug with potent arterial and coronary vasodilating properties.
Drug Characteristics: Amlodipine
Medication Safety Issues: Amlodipine
Drug Interactions: Amlodipine
Adverse Reactions: Amlodipine
Efficacy Monitoring Parameters. Decreased blood pressure, reduction of chest pain, decreased number of weekly angina attacks, reduction in use of prophylactic nitroglycerin to relieve chest pain, improvement in signs/symptoms of CHF.
Toxicity Monitoring Parameters. Signs/symptoms of peripheral edema, increased heart rate, LFTs.
Key Patient Counseling Points. Instruct patient to report signs/symptoms of hypotension or exacerbation of angina with initial dosing and dose changes. Avoid alcohol while taking drug. Report signs/symptoms of peripheral edema, fatigue, hypotension, or hepatic dysfunction. Do not discontinue drug suddenly as this may cause rebound hypertension. This medicine may cause dizziness. Avoid activities that could be dangerous if not alert. Dizziness may be worse if too much water is lost from the body due to excessive sweating, diarrhea, or vomiting.
Clinical Pearls. Safety and efficacy not established in pediatric patients younger than 6 y of age. Elderly, small, or frail patients, or when adding to other antihypertensive therapy, decrease initial dose, 2.5 mg po daily.