Top 300 Pharmacy Drug Cards


Class: β-Lactam Antibiotic

Dosage Forms. Tablet: 250 mg amoxicillin/125 mg clavulanic acid, 500 mg amoxicillin/125 mg clavulanic acid; 875 mg amoxicillin/125 mg clavulanic acid; Tablet, Extended Release: 1000 mg amoxicillin/62.5 mg clavulanic acid; Chewable Tablet: 125 mg amoxicillin/31.25 mg clavulanic acid, 250 mg amoxicillin/62.5 mg clavulanic acid; 200 mg amoxicillin/28.5 mg clavulanic acid, 400 mg amoxicillin/57 mg clavulanic acid; Suspension: 25 mg amoxicillin/6.25 mg clavulanic acid/mL, 50 mg amoxicillin/12.5 mg clavulanic acid/mL; 40 mg amoxicillin/5.7 mg clavulanic acid/mL, 80 mg amoxicillin/11.4 mg clavulanic acid/mL

Common FDA Label Indication, Dosing, and Titration.

1. Acute otitis media: Adults, 500-875 mg po q12h × 10 d; Children, 80-90 mg/kg/d po in 2-3 divided doses

2. Community acquired pneumonia: Adults, 2000 mg po bid × 7-10 d

3. Lower respiratory tract infection: Adults, 1000 mg po tid × 10 d; Children, 45 mg/kg/d po divided q12h

4. Sinusitis, infection of skin or subcutaneous tissue, infectious disease of genitourinary system: Adults, 500-875 mg po q12h × 10 d; Children, 25-45 mg/kg/d po divided q12h


Other Uses.

1. Streptococcal pharyngitis: Adults, 875 mg po q12h or 500 mg po q8h; Children, 45 mg/kg/d divided q12h

MOA. Amoxicillin is a semisynthetic penicillin derivative. Typically active against Streptococcus, Enterococcus, Staphylococcus, and Enterobacteriaceae. Amoxicillin is not effective against β-lactamase-producing bacteria. Clavulanic acid has weak antibacterial activity but is a potent inhibitor of plasmid-mediated β-lactamases.

Drug Characteristics: Amoxicillin/Potassium Clavulanate


Medication Safety Issues: Amoxicillin/Potassium Clavulanate


Drug Interactions: Amoxicillin/Potassium Clavulanate


Adverse Reactions: Amoxicillin/Potassium Clavulanate


Efficacy Monitoring Parameters. Resolution of clinical signs of infection.

Toxicity Monitoring Parameters. Severe diarrhea, dark urine, yellowing of skin or eye, unusual bruising or bleeding, blistering skin rash, or shortness of breath.

Key Patient Counseling Points. Complete full course of therapy. For the suspension, shake well and store in the refrigerator. Note short expiration after reconstitution. Avoid mixing suspension with food or beverages, but food can be taken afterward. Symptoms should improve within 2-3 d; if they worsen, seek follow-up with healthcare practitioner.

Clinical Pearls. There is cross hypersensitivity between penicillin and cephalosporin; use with caution in cephalosporin allergic patients. Incidence of diarrhea is higher than with amoxicillin alone.

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