Class: Benzodiazepine. C-IV
Dosage Forms. Capsule: 7.5 mg, 15 mg, 22.5 mg, 30 mg
Common FDA Label Indication, Dosing, and Titration.
1. Insomnia: 7.5-30 mg po daily hs
Off-Label Uses. None
MOA. Temazepam is a minor metabolite of diazepam. Enhances the postsynaptic effect of the inhibitory neurotransmitter, γ-aminobutyric acid (GABA).
Drug Characteristics: Temazepam
Medication Safety Issues: Temazepam
Drug Interactions: Temazepam
Adverse Reactions: Temazepam
Efficacy Monitoring Parameters. Improved ability to fall asleep and sleep through night.
Toxicity Monitoring Parameters. Seek medical attention if severe drowsiness, thoughts of suicide, allergic reaction, or slow or irregular heartbeat. Monitor vital signs.
Key Patient Counseling Points. May cause drowsiness; avoid driving or other tasks requiring motor coordination. Avoid alcohol. Take 30 min prior to bedtime. May cause complex behaviors (driving, talking on phone, etc while not fully awake); bed partner should monitor and temazepam should be discontinued.
Clinical Pearls. Not for long-term use (usually 7-10 d only). Use caution in elderly, appear more sensitive to the effects; dose reductions of 50% have been recommended. Use CNS depressants with caution, may have additive effects. Avoid abrupt discontinuation after chronic use, may cause seizures.