Top 300 Pharmacy Drug Cards


Class: Potassium Sparing/Thiazide Diuretic Combination

Dosage Forms. Capsule: (Triamterene/Hydrochlorothiazide) 37.5 mg/25 mg, 50 mg/25 mg; Tablet: (Triamterene/Hydrochlorothiazide) 37.5 mg/25 mg, 50 mg/25 mg, 75 mg/50 mg


Common FDA Label Indication, Dosing, and Titration.

1. Edema: 37.5 mg/25 mg, 1-2 tablets or capsules po daily

2. Hypertension: 37.5 mg/25 mg, 1 tablet or capsule po daily, may titrate to 75 mg/50 mg po daily

Off-Label Uses. None

MOA. Triamterene acts directly from the distal tubular lumen on active sodium exchange for potassium and hydrogen, producing a mild diuresis that is independent of aldosterone concentration. Antihypertensive activity is inconsistent and less pronounced than with thiazides or spironolactone. Hydrochlorothiazide is a thiazide diuretic that increases sodium and chloride excretion by interfering with their reabsorption in the cortical diluting segment of the nephron; a mild diuresis of slightly concentrated urine results.

Drug Characteristics: Triamterene/Hydrochlorothiazide


Medication Safety Issues: Triamterene/Hydrochlorothiazide


Drug Interactions: Triamterene/Hydrochlorothiazide


Adverse Reactions: Triamterene/Hydrochlorothiazide


Efficacy Monitoring Parameters. Decreased blood pressure, reductions in edema.

Toxicity Monitoring Parameters. Altered serum and urine electrolytes (calcium, magnesium, potassium, sodium), decreased renal function (increased SCr or decreased urine output), increased serum uric acid or blood glucose. Seek medical attention if skin rash, yellowing of eyes or skin, or decreased urine output occurs or symptoms of gout occur.

Key Patient Counseling Points. May cause dizziness. Avoid driving, using machinery, or doing anything else that could be dangerous if not alert. Avoid alcohol and NSAIDs. May cause photosensitivity; use sunscreen. Use with caution in patients with sulfonamide allergy.

Clinical Pearls. Safety and effectiveness not established in children.

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