Top 300 Pharmacy Drug Cards

AZELASTINE: Astelin, Various

Class: Nasal Antihistamine

Dosage Forms. Nasal Spray: 137 mcg/actuation

Common FDA Label Indication, Dosing, and Titration.

1. Perennial allergic rhinitis: 2 sprays per nostril bid

2. Seasonal allergic rhinitis: 1-2 sprays per nostril bid

3. Vasomotor rhinitis: 2 sprays per nostril bid

Off-Label Uses. None

MOA. Azelastine is a selective H1-receptor antagonist that blocks release of histamine from cells involved in the allergic response. It also inhibits other mediators of allergic reactions (eg, leukotrienes, etc), and reduces chemotaxis and eosinophil activation.


Drug Characteristics: Azelastine


Medication Safety Issues: Azelastine


Drug Interactions: Azelastine


Adverse Reactions: Azelastine


Efficacy Monitoring Parameters. Decrease in rhinitis symptoms.

Toxicity Monitoring Parameters. Seek medical attention if severe allergic reactions occur.

Key Patient Counseling Points. Avoid spraying in eyes. Somnolence has been reported with nasal administration; instruct patient to avoid alcohol use and hazardous activities such as driving or operating machinery until level of sedation is known.

Clinical Pearls. Also available as ophthalmic drop for ocular rhinitis symptoms.