Top 300 Pharmacy Drug Cards

BENZTROPINE MESYLATE: Cogentin, Various

Class: Antiparkinsonian, Anticholinergic

Dosage Forms. Tablet: 0.5 mg, 1 mg, 2 mg

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Common FDA Label Indication, Dosing, and Titration.

1. Extrapyramidal disease, medication-induced movement disorder: Adults, 1-4 mg po daily or bid; Children 3 y and older, 1-2 mg/kg/d

2. Parkinsonism: 1-2 mg/d po, may titrate to range 0.5-6 mg/d po

Off-Label Uses. None

MOA. Benztropine mesylate possesses anticholinergic and antihistamine effects. May inhibit reuptake and storage of dopamine.

Drug Characteristics: Benztropine

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Medication Safety Issues: Benztropine

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Drug Interactions: Benztropine

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Adverse Reactions: Benztropine

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Efficacy Monitoring Parameters. Reduction of extrapyramidal movements, rigidity, tremor, gait disturbances.

Toxicity Monitoring Parameters. Monitor for anticholinergic effects including dry mouth and constipation.

Key Patient Counseling Points. Drug may impair heat regulation. Advise patient to use caution with activities leading to an increased core temperature, such as strenuous exercise, exposure to extreme heat, or dehydration. Patient should avoid activities requiring mental alertness or coordination until drug effects are realized. Instruct patient to report sudden muscle weakness or stiffness, and signs/symptoms of tardive dyskinesia (tongue thrusting, facial grimacing/tics, random movements of extremities). Patient should not drink alcohol while taking this drug.

Clinical Pearls. Benztropine may have more adverse effects than amantadine when used for Parkinson disease.