Class: Prostaglandin, Antiglaucoma Agent, Cosmetic Agent for Eyelash Growth
Dosage Forms. Ophthalmic Solution: 0.01%, 0.03%
Common FDA Label Indication, Dosing, and Titration.
1. Ocular hypertension and open angle glaucoma: 1 drop in affected eye(s) daily in the evening
2. Hypotrichosis of the eyelashes: Apply 1 drop nightly to clean, upper eyelid margin at base of eyelashes, blot excess, repeat with new sterile applicator to opposite eyelid, do not apply to lower eyelids
Off-Label Uses. None
MOA. Bimatoprost is a synthetic prostaglandin analog. Bimatoprost lowers intraocular pressure (IOP) by increasing the outflow of aqueous humor through both the trabecular meshwork and uveoscleral drainage systems. The exact mechanism of action for bimatoprost in stimulating eyelash growth is unknown.
Drug Characteristics: Bimatoprost
Medication Safety Issues: Bimatoprost
Drug Interactions: Bimatoprost
Adverse Reactions: Bimatoprost
Efficacy Monitoring Parameters. Reduction in IOP. Desired growth of eyelashes and resulting improvement in social life.
Toxicity Monitoring Parameters. Seek medical attention if symptoms of ocular irritation are severe.
Key Patient Counseling Points. Wash your hands and remove contact lenses before using the medicine. For administration of Lumigan, lie down or tilt head back. With index finger, pull down the lower lid of eye to form a pocket. Hold the dropper close to eye with the other hand. Drop the correct number of drops into the pocket made between lower lid and eyeball. Gently close eyes. Place index finger over the inner corner of eye for 1 min. Do not rinse or wipe the dropper or allow it to touch anything, including eye. Put the cap on the bottle right away. Separate from other eye drops by 5 min. For administration of Latisse, wash face and remove makeup before applying. Do not rinse eye if solution gets into the eye. Do not reuse supplied sterile applicators or use any other brush/applicator other than those supplied. Use a new applicator for second eye. Do not apply to lower lid, or more than once per day. Reinsert contact lens after 15 min.
Clinical Pearls. There is a risk of permanent increased iris pigmentation associated with instillation of this product, and with leakage of Latisse into the eye. The effect of Latisse on eyelash length, thickness, and darkness is not permanent and will return to baseline upon discontinuation of bimatoprost.