Top 300 Pharmacy Drug Cards

CARISOPRODOL: Soma, Various

Class: Centrally Acting Skeletal Muscle Relaxant

Dosage Forms. Tablet: 250 mg, 350 mg

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Common FDA Label Indication, Dosing, and Titration.

1. Disorder of musculoskeletal system: 250-350 mg po tid and hs

Off-Label Uses. None

MOA. Carisoprodol blocks interneuronal activity in descending reticular formation and spinal cord, resulting in muscle relaxation.

Drug Characteristics: Carisoprodol

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Medication Safety Issues: Carisoprodol

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Drug Interactions: Carisoprodol

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Adverse Reactions: Carisoprodol

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Efficacy Monitoring Parameters. Reduction in pain and muscle spasms.

Toxicity Monitoring Parameters. Seek medical attention if idiosyncratic symptoms such as extreme weakness, transient quadriplegia, dizziness, confusion occur within minutes or hours after first dose.

Key Patient Counseling Points. Patients should avoid activities requiring mental alertness or coordination until drug effects are known, as drug may cause dizziness or sedative effects. Patients withdrawing from prolonged therapy should be monitored carefully for withdrawal symptoms, including seizures.

Clinical Pearls. Carisoprodol is used for the relief of discomfort associated with acute, painful musculoskeletal conditions in adults and should be used for only short periods (up to 2 or 3 wk). The drug was approved by the FDA in 1959 and limited pharmacologic and pharmacokinetic data are available.