Class: Third-Generation Cephalosporin
Dosage Forms. Powder for Suspension: 125 mg/5 mL, 250 mg/5 mL; Capsule: 300 mg
Common FDA Label Indication, Dosing, and Titration.
1. Acute otitis media: Children 6 mo through 12 y, 7 mg/kg po bid q12h × 5-10 d
2. Bronchitis, acute, secondary bacterial infection: Adults, 300 mg po bid × 5-10 d; Children 13 y and older, 300 mg po bid × 5-10 d
3. Community acquired pneumonia, uncomplicated skin and/or subcutaneous tissue infection: 300 mg po bid × 10 d
Off-Label Uses. None
MOA. Cefdinir is a third-generation cephalosporin with activity against a number of Gram-positive and Gram-negative bacteria including β-lactamase-producing strains.
Drug Characteristics: Cefdinir
Medication Safety Issues: Cefdinir
Drug Interactions: Cefdinir
Adverse Reactions: Cefdinir
Efficacy Monitoring Parameters. Resolution of infection.
Toxicity Monitoring Parameters. Seek medical attention if severe diarrhea.
Key Patient Counseling Points. Complete full course of therapy. For the suspension, shake well and store in the refrigerator. Note short expiration after reconstitution. Avoid mixing suspension with food or beverages, but food can be taken afterward. Symptoms should improve within 2-3 d; if they worsen, seek follow-up with healthcare practitioner. Separate administration of antacids, iron, and vitamins by 2 h.
Clinical Pearls. May resume normal activities after 24 h of antibiotics and if afebrile. Ten percent of patients allergic to penicillin are also allergic to cephalosporin; use with caution in penicillin-allergic patients.