Top 300 Pharmacy Drug Cards

CETIRIZINE: Zyrtec, Various

Class: Antihistamine

Dosage Forms. Syrup: 1 mg/mL; Tablet: 5 mg, 10 mg; Tablet, Chewable: 5 mg, 10 mg; Capsule: 10 mg; Solution: 1 mg/mL

Common FDA Label Indication, Dosing, and Titration.

1. Perennial or seasonal allergic rhinitis: Children 6-23 mo, 2.5 mg po daily; Children 2-5 y, 2.5-5 mg po daily; Children 6 y and older and Adults, 5-10 mg po daily

2. Urticaria, chronic: Children 6-23 m, 2.5 mg po daily; Children 2-5 y, 2.5-5 mg po daily; Children 6 y and older and Adults, 5-10 mg po daily

Off-Label Uses.

1. Atopic dermatitis: Children 6-23 m, 2.5 mg po daily; Children 2-5 y, 2.5-5 mg po daily; Children 6 y and older and Adults, 5-10 mg po daily

MOA. Cetirizine is a low-sedating, long-acting H1-receptor antagonist that is a metabolite of hydroxyzine. Cetirizine competitively inhibits the interaction of histamine with H1 receptors, thereby preventing the allergic response.

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Drug Characteristics: Cetirizine

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Medication Safety Issues: Cetirizine

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Drug Interactions: Cetirizine

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Adverse Reactions: Cetirizine

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Efficacy Monitoring Parameters. Improvement in rhinitis or urticaria symptoms.

Toxicity Monitoring Parameters. Seek medical attention for signs of severe CNS toxicity.

Key Patient Counseling Points. Patients should avoid activities requiring mental alertness or coordination until drug effects are known, as drug may cause dizziness or sedative effects.

Clinical Pearls. Product is available over the counter in several dosage forms.