Top 300 Pharmacy Drug Cards


Class: Anticonvulsant. C-IV

Dosage Forms. Tablet: 5 mg, 10 mg, 20 mg

Common FDA Label Indication, Dosing, and Titration.

1. Lennox-Gastaut syndrome: Children 2 y and older and ≤30 kg, 5 mg po daily, may titrate to 20 mg po daily; Adults and Children 2 y and older and >30 kg, 10 mg po daily, may titrate to 40 mg po daily

Off-Label Uses.

1. Alcohol withdrawal syndrome: 0.3-0.9 mg/kg/d po × 1 wk

2. Anxiety: 20-80 mg po daily (single or divided doses) × 5-14 d

MOA. Clobazam is a benzodiazepine. The exact mechanism of action for clobazam is not known, but is thought to involve potentiation of GABAergic neurotransmission resulting from binding at the benzodiazepine site of the GABAA receptor.


Drug Characteristics: Clobazam


Medication Safety Issues: Clobazam


Drug Interactions: Clobazam


Adverse Reactions: Clobazam


Efficacy Monitoring Parameters. Decrease in the frequency of seizures. Reduction in anxiety.

Toxicity Monitoring Parameters. Signs and symptoms of CNS depression, suicidal thoughts or behaviors, unusual changes in mood or behavior.

Key Patient Counseling Points. Often causes lethargy and somnolence. Avoid alcohol while using. Avoid activities requiring mental alertness.

Clinical Pearls. Not indicated for children less than 2 y of age. Many drug-drug interactions; monitor concurrent drug use carefully. Medication guide required when dispensing.

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