Top 300 Pharmacy Drug Cards

DICYCLOMINE: Bentyl, Various

Class: Antimuscarinic

Dosage Forms. Capsule: 10 mg; Tablet: 20 mg; Syrup: 10 mg/5 mL

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Common FDA Label Indication, Dosing, and Titration.

1. Irritable bowel syndrome: Children 6 mo-2 y of age, 5 mg po tid-qid; Children 2-12 y of age, 10 mg po tid, may titrate to 40 mg/d; Adults, 20 mg po qid, may titrate to 40 mg po qid

Off-Label Uses. None

MOA. Dicyclomine relieves smooth muscle spasm of the gastrointestinal tract via a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and a direct effect on smooth muscle (musculotropic).

Drug Characteristics: Dicyclomine

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Medication Safety Issues: Dicyclomine

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Drug Interactions: Dicyclomine

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Adverse Reactions: Dicyclomine

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Efficacy Monitoring Parameters. Improved bowel function, decreased flatulence, diarrhea.

Toxicity Monitoring Parameters. Rapid heart beat, severe dizziness, unusual thoughts, shortness of breath, or severe rash.

Key Patient Counseling Points. May cause drowsiness; avoid driving, and operating heavy equipment. Heat prostration (due to decreased sweating) can occur when used in a hot environment.

Clinical Pearls. There are reports that administration of dicyclomine to infants has been followed by serious respiratory symptoms (dyspnea, shortness of breath, breathlessness, respiratory collapse, apnea, asphyxia), seizures, syncope, pulse rate fluctuations, muscular hypotonia, and coma. Death has been reported.