Top 300 Pharmacy Drug Cards

DIPYRIDAMOLE: Persantine, Various

Class: Platelet Aggregation Inhibitor

Dosage Forms. Tablet: 25 mg, 50 mg, 75 mg

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Common FDA Label Indication and Dosing.

1. Thromboprophylaxis after heart valve replacement: 75-100 mg po qid as an adjunct to warfarin therapy

Off-Label Uses. None

MOA. Inhibits the uptake of adenosine into platelets, endothelial cells, and erythrocytes resulting in an increase in local concentrations of adenosine, which is a coronary vasodilator and a platelet aggregation inhibitor.

Drug Characteristics: Dipyridamole

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Medication Safety Issues: Dipyridamole

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Drug Interactions: Dipyridamole

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Adverse Reactions: Dipyridamole

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Efficacy Monitoring Parameters. Prevention of AMI, stroke, other thrombotic complications.

Toxicity Monitoring Parameters. Signs/symptoms of dizziness, GI distress.

Key Patient Counseling Points. Rise slowly from a sitting/supine position. Avoid alcohol.

Clinical Pearls. Safety and effectiveness in pediatric patients have not been studied. Injectable product also available for radionuclide cardiac perfusion studies. Oral combination product with dipyridamole and aspirin also available. Use with caution in the elderly.