Top 300 Pharmacy Drug Cards

DOXYCYCLINE: Vibramycin, Various

Class: Tetracycline Antibiotic

Dosage Forms. Powder for Suspension: 25 mg/5 mL; Tablet: 20 mg, 50 mg, 75 mg, 100 mg, 150 mg; Tablet, Delayed Release: 75 mg, 100 mg, 150 mg; Capsule: 50 mg, 75 mg, 100 mg, 150 mg

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Common FDA Label Indication, Dosing, and Titration.

1. Acinetobacter infection: Children <8 y and <45 kg, 2.2-4.4 mg/kg po in 1-2 divided doses; Children >8 y and >45 kg and Adults, 100 mg po q12h on day 1, then 100 mg po daily

2. Acne vulgaris: Children <8 y and <45 kg, 2.2-4.4 mg/kg po in 1-2 divided doses; Children >8 y and >45 kg and Adults, 100 mg po q12h on day 1, then 100 mg po daily or bid

3. Gonorrhea, uncomplicated: 100 mg po bid × 7 d or 300-mg po single dose followed in 1 h by another 300-mg dose

4. Staphylococcal infection of skin: Children <8 y and <45 kg, 2.2-4.4 mg/kg po in 1-2 divided doses; Children > 8 y and >45 kg and Adults, 100 mg po q12h on day 1, then 100 mg po daily

Off-Label Uses.

1. Lyme disease, prophylaxis: 200 mg po as a single dose

MOA. Doxycycline is a broad-spectrum bacteriostatic compound that inhibits protein synthesis at the 30S ribosomal subunit. Activity includes Gram-positive, Gram-negative, aerobic, and anaerobic bacteria, as well as spirochetes, mycoplasmas, rickettsiae, chlamydiae, and some protozoa. Many bacteria have developed plasmid-mediated resistance.

Drug Characteristics: Doxycycline

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Medication Safety Issues: Doxycycline

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Drug Interactions: Doxycycline

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Adverse Reactions: Doxycycline

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Monitoring Parameters Efficacy. Resolution of symptoms of infection.

Monitoring Parameters Toxicity. Burning or pain in the stomach, extreme headache, bloody diarrhea, tooth darkening.

Key Patient Counseling Points. May take with food that does not contain calcium. Complete full course of therapy. Symptoms should improve within 2-3 d. Wear sunscreen. Administer with 8 ounces of water.

Clinical Pearls. May resume normal activities after 24 h of antibiotics if afebrile. Not for use in children under the age of 8 y (bone and tooth discoloration).