BMA Concise Guide to Medicine & Drugs

Naftidrofuryl

Brand name Praxilene

Used in the following combined preparations None

QUICK REFERENCE

Drug group Vasodilator

Overdose danger rating Medium

Dependence rating Low

Prescription needed Yes

Available as generic Yes

GENERAL INFORMATION

Naftidrofuryl is a vasodilator drug used in the treatment of peripheral circulatory disorders such as Raynaud’s syndrome or intermittent claudication (cramp-like pain). Most of these conditions are caused by blockage of blood vessels due to spasms or sclerosis (hardening) of the vessel walls.

Naftidrofuryl may improve symptoms and mobility in these conditions, but it is not known if it has any influence on their progress. Lifestyle changes such as giving up smoking and taking exercise (and keeping warm in the case of Raynaud’s) are often helpful.

Naftidrofuryl has also been used for treating night cramps, but it is not known how the drug works to reduce them. It has also been tried for circulatory disorders in the brain.

INFORMATION FOR USERS

Your drug prescription is tailored for you. Do not alter dosage without checking with your doctor.

How taken/used Capsules.

Frequency and timing of doses 3 x daily with meals, swallowed whole with at least one glass of water.

Adult dosage range 300–600mg daily.

Onset of effect 1 hour.

Duration of action 8 hours.

Diet advice Drink plenty of water during treatment.

Storage Keep in original container at room temperature out of the reach of children.

Missed dose Take when you remember. If your next dose is due within 2 hours, take a single dose now and skip the next.

Stopping the drug Do not stop taking the drug without consulting your doctor; symptoms may recur.

Exceeding the dose An occasional unintentional extra dose is unlikely to cause problems. Large overdoses may cause heart problems and seizures. Notify your doctor immediately.

POSSIBLE ADVERSE EFFECTS

Naftidrofuryl is generally well tolerated. Its most common side effect is nausea. Rarely, chest pain, rash, jaundice, or seizures may occur. Consult your doctor if you have any of these rarer side effects and, if you have jaundice or seizures, stop taking the drug.

INTERACTIONS

None known.

SPECIAL PRECAUTIONS

Be sure to tell your doctor if:

· You have liver or kidney problems.

· You are taking other medicines.

Pregnancy Safety not established. Discuss with your doctor.

Breast-feeding Safety not established. Discuss with your doctor.

Infants and children Not recommended.

Over 60 No special problems.

Driving and hazardous work No special problems.

Alcohol No special problems.

PROLONGED USE

Treatment should be reviewed after 3 months to see if the condition is improving, or if the drug should be stopped.