Medical Physiology, 3rd Edition

References

Books and Reviews

Abumrad NA, Davidson NO. Role of the gut in lipid homeostasis. Physiol Rev. 2012;92(3):1061–1085.

Anderson CM, Stahl A. SLC27 fatty acid transport proteins. Mol Aspects Med. 2013;34:516–528.

Carey MC, Hernell O. Digestion and absorption of fat. Semin Gastroenterol. 1992;3:189–204.

Civitelli R, Avioli LV. Calcium, phosphate and magnesium absorption. Johnson LR. Physiology of the Gastrointestinal Tract. 3rd ed. Raven Press: New York; 1994:2173–2182.

Daniel H. Molecular and integrative physiology of intestinal peptide transport. Annu Rev Physiol. 2004;66:361–384.

Debnam ES, Srai SKS. Intestinal iron absorption: Cellular mechanism and regulation. News Physiol Sci. 1997;12:184–189.

Farrell JJ. Digestion and absorption of nutrients and vitamins. 7th ed. Saunders: Philadelphia; 2002:1715–1750. Feldman M, Friedman LS, Sleisenger MH. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. vol 2.

Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: Molecular control of mammalian iron metabolism. Cell. 2004;117:285–297.

Johnson LR. Physiology of the Gastrointestinal Tract. 3rd ed. Raven Press: New York; 1994.

Marsh MN, Riley SA. Digestion and absorption of nutrients and vitamins. 6th ed. WB Saunders: Philadelphia; 1998:1471–1500. Feldman M, Scharschmidt BF, Sleisenger MH. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. vol 2.

Palacin M, Estevez R, Bertran J, Zorzano A. Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev. 1998;78:969–1054.

Su X, Abumrad NA. Cellular fatty acid uptake: A pathway under construction. Trends Endocrinol Metab. 2009;20(2):72–77.

Verrey F, Ristic Z, Romeo E, et al. Novel renal amino acid transporters. Annu Rev Physiol. 2005;67:557–572.

Wright EM. The intestinal Na+/glucose cotransporter. Annu Rev Physiol. 1993;55:575–589.

Journal Articles

Bala PA, Foster J, Carvelli L, Henry LK. SLC6 transporters: Structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 2013;34(2–3):197–219.

Clarke DC, Miskovic D, Han XX, et al. Overexpression of membrane-associated fatty acid binding protein (FABPpm) in vivo increases fatty acid sarcolemmal transport and metabolism. Physiol Genomics. 2004;17:31–37.

Faham S, Watanabe A, Besserer GM, et al. The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science. 2008;321(5890):810–814.

Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996;13:399–408.

Fei YJ, Kanai Y, Nussberger S, et al. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature. 1994;368:563–566.

Fotiadis D, Kanai Y, Palacín M. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med. 2013;34:139–158.

Gunshin H, Mackenzie B, Berger UV, et al. Cloning and characterization of a proton-coupled mammalian metal ion transporter. Nature. 1997;388:482–488.

Montalbetti N, Simonin A, Kovacs G, Hediger MA. Mammalian iron transporters: Families SLC11 and SLC40. Mol Aspects Med. 2013;34:270–287.

Pramod AB, Foster J, Carvelli L, Henry LK. SLC6 transporters: Structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 2013;34:197–219.

Shiau YF. Mechanisms of intestinal fatty acid uptake in the rat: The role of an acidic microclimate. J Physiol. 1990;421:463–474.

Smith DE, Clémençon B, Hediger MA. Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications. Mol Aspects Med. 2013;34(2–3):323–336.

Verrey F, Closs EL, Wagner CA, et al. CATs and HATs: The SLC7 family of amino acid transporters. Pflugers Arch. 2004;447(5):532–542.

 

SMALL INTESTINE

LARGE INTESTINE

Length (m)

6

2.4

Area of apical plasma membrane (m2)

~200

~25

Folds

Yes

Yes

Villi

Yes

No

Crypts or glands

Yes

Yes

Microvilli

Yes

Yes

Nutrient absorption

Yes

No

Active Na+ absorption

Yes

Yes

Active K+ secretion

No

Yes