Drugs in Pregnancy and Lactation: Tenth Edition

VACCINE, BCG

Vaccine

PREGNANCY RECOMMENDATION: Compatible—Maternal Benefit >> Embryo–Fetal Risk

BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible

PREGNANCY SUMMARY

BCG vaccine is a live, attenuated bacteria vaccine used to provide immunity to tuberculosis (1). Animal reproduction studies have not been conducted with the vaccine. The risk to the fetus from maternal vaccination is unknown. Because it is a live preparation, the CDC recommends that it not be used in pregnancy (2).

BREASTFEEDING SUMMARY

No reports describing the use of BCG vaccine in human lactation have been located. However, there does not appear to be any risk to a nursing infant if the mother receives the vaccine (2).

References

1.American Hospital Formulary Service. Drug Information 1997. Bethesda, MD: American Society of Health-System Pharmacists, 1997:2569–72.

2.CDC. Guidelines for Vaccinating Pregnant Women. Available at http://www.cdc.gov/vaccines/pubs/preg-guide.htm. Accessed May 16, 2010.