Drugs in Pregnancy and Lactation: Tenth Edition

IMMUNE GLOBULIN, HEPATITIS B

Serum

PREGNANCY RECOMMENDATION: Compatible

BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible

PREGNANCY SUMMARY

The American College of Obstetricians and Gynecologists recommends use of hepatitis B immune globulin in pregnancy for postexposure prophylaxis (1).

FETAL RISK SUMMARY

Hepatitis B immune globulin is used to provide passive immunity following exposure to hepatitis B. When hepatitis B occurs during pregnancy, an increased rate of abortion and prematurity may be observed (1). No risk to the fetus from the immune globulin has been reported (13).

BREASTFEEDING SUMMARY

No reports describing the use of hepatitis B immune globulin during human lactation have been located.

References

1.American College of Obstetricians and Gynecologists. Viral hepatitis in pregnancy. ACOG Practice Bulletin. No. 86, October 2007. Obstet Gynecol 2007;110:941–55.

2.Amstey MS. Vaccination in pregnancy. Clin Obstet Gynaecol 1983;10:13–22.

3.CDC. Guidelines for vaccinating pregnant women. Available at www.cdc.gov/vaccines/pubs/preg-guide.htm. Accessed May 16, 2010.



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