Serum
PREGNANCY RECOMMENDATION: Compatible
BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible
PREGNANCY SUMMARY
The American College of Obstetricians and Gynecologists recommends use of hepatitis B immune globulin in pregnancy for postexposure prophylaxis (1).
FETAL RISK SUMMARY
Hepatitis B immune globulin is used to provide passive immunity following exposure to hepatitis B. When hepatitis B occurs during pregnancy, an increased rate of abortion and prematurity may be observed (1). No risk to the fetus from the immune globulin has been reported (1–3).
BREASTFEEDING SUMMARY
No reports describing the use of hepatitis B immune globulin during human lactation have been located.
References
1.American College of Obstetricians and Gynecologists. Viral hepatitis in pregnancy. ACOG Practice Bulletin. No. 86, October 2007. Obstet Gynecol 2007;110:941–55.
2.Amstey MS. Vaccination in pregnancy. Clin Obstet Gynaecol 1983;10:13–22.
3.CDC. Guidelines for vaccinating pregnant women. Available at www.cdc.gov/vaccines/pubs/preg-guide.htm. Accessed May 16, 2010.