PREGNANCY RECOMMENDATION: Compatible—Maternal Benefit >> Embryo–Fetal Risk
BREASTFEEDING RECOMMENDATION: No Human Data—Probably Compatible
Protamine is used to neutralize the anticoagulant effect of heparin. No reports of its use in pregnancy have been located. Reproduction studies in animals have not been conducted (1).
No reports describing the use of protamine during human lactation have been located. Such reports are unlikely due to its indication.
1.Product information. Protamine sulfate. Eli Lilly, 1993.