Neck Surgery. Brendan C. Stack, Jr., Mauricio A. Moreno, MD

1. Clinical Assessment of Neck Lymphadenopathies

M. Kürşat Gökcan and Emre A. Vural Abstract

Cervical lymphadenopathy is a common cause of clinic visits, which necessitates rapid and efficient diagnosis. The key requirement for this practice is the combination of the recognition of various risk factors in patients’ history with the understanding of neck anatomy and appropriate usage of diagnostic tools such as imaging and biopsies. This chapter aims to provide necessary information for clinicians in obtaining a thorough history and head and neck examination, as well as employing the correct imaging algorithm and the differential diagnosis in patients with cervical lymphadenopathy.

Keywords: neck mass, lymphadenopathy, differential diagnosis, diagnostic imaging, pediatric lymphadenopathy, congenital lesions, neoplasms of the neck, carcinoma of unknown primary

1.1 Introduction

Neck is the bridge between the head and the trunk. Besides conveying spinal cord in a chamber made of vertebrae and muscles, neck contains important vasculature, nerves, fat and lymphatics, and elements of upper aerodigestive tract, as well as salivary, thyroid, and parathyroid glands. Seeing a lump or a swelling in the neck is a very common clinical finding in all age groups, which can be related to the structures in the neck or can be part of an infectious, inflammatory, or a neoplastic process. Therefore, diagnostic workup may pose a major challenge in the daily practice of any physician.

The scope of this chapter is to provide a systematical approach for the evaluation of neck masses, specifically cervical lymphadenopathies, which entails obtaining a thorough history from the patient, performing a complete physical examination including endoscopy, utilizing relevant imaging modalities, and performing biopsies in the form of needle aspiration or excision as necessary. Many characteristics of the patient and the findings in the history are invaluable in presumptive diagnosis, and may help direct the subsequent physical examination and in selecting the appropriate laboratory and imaging studies. Detailed head and neck physical examination is the crucial step for proper diagnosis and management. Imaging should be directed for better delineation of pathology and/or involved nodal groups.

1.2 History and Physical Examination

A mass in the neck is a very common finding in patients of all age groups. Despite significant progress in clinical diagnostic and imaging modalities, history and physical examination of a patient with neck mass still remains the mainstay of diagnosis. A rapidly growing, tender mass in a child usually consists of reactive lymph nodes that are caused by inflammation after infections. On the other hand, a slow-growing, firm mass in a heavy drinker and smoker elderly male could be metastatic lymph node from a primary malignancy in the upper aerodigestive tract. More than 90% of all neck masses were estimated to be benign in pediatric age group, while—excluding thyroid masses —80% of adult neck masses are neoplastic and 80% of those are malignant.1 Therefore, every piece of information gathered from history of the patient and the present illness is not only important for obtaining a proper diagnosis, but may also save time by preventing unnecessary tests.

History taking should be concentrated on the history of the present illness, onset and duration of the neck mass, and any associated symptoms such as pain, fever, anorexia, weight loss, night sweats, fatigue, otalgia, throat pain, dysphonia, dysphagia, odynophagia, hoarseness, and/or dyspnea. Past medical, surgical, social, and family histories are important parts of patient’s evaluation. Patient’s tobacco and/or alcohol consumption, its duration and intensity, and occupational exposures to environmental toxins, recent travels especially to exotic regions, exposure to animals and sexually transmitted diseases such as human papillomavirus (HPV), and any history of radiation to the head and neck should also be noted.

After obtaining a detailed history, a careful head and neck physical examination should be carried out for evaluation of craniofacial skin, eyes, oral cavity, oropharynx, larynx, hypo- pharynx, ears, nasal cavity, and nasopharynx. Palpation of neck nodal basins, salivary glands, and thyroid, and bimanual palpation of tongue, tonsil, and floor of mouth should be part of the physical examination. A key adjunct to visual inspection is the fiberoptic endoscopy, which not only allows a thorough examination of the upper aerodigestive tract with illumination and magnification, but also provides a dynamic evaluation of swallowing and airway.

Features of a palpable mass include mobility, tenderness, location in the neck, firmness, fluctuance, overlying erythema, pulsation, and palpable bruits.1 Several features may help in differentiating a benign reactive lymphadenopathy from a lymph node harboring malignancy. Cervical lymphadenopathy associated with viral infections is often soft, small, bilateral, mobile, nontender, and without overlying skin changes, although this general rule may not be true with some of the more subacute and chronic viral infections, such as Epstein-Barr virus (EBV) and cytomegalovirus.23 Cervical lymphadenopathy associated with bacterial infections is usually of acute onset and unilateral. Bacterial lymphadenitis develops more commonly in submandibular (50-60%) or upper cervical (25-30%) regions compared with other cervical lymph node subsites.3 Up to 25% of patients with acute bacterial lymphadenitis will demonstrate fluctuance on physical examination, and this is especially true with Staphylococcus aureus lymphadenitis.3 Concerning findings that may suggest malignancy include nodes that are rapidly enlarging, firm, nontender, and fixed-to-the-skin or underlying structures. Also, generalized lymphadenopathy, supraclavicular nodes regardless of size, lower cervical nodes, lymph nodes greater than 2 to 3 cm, and accompanying hepatosplenomegaly are associated with increased risk of malignancy.4

One should always keep in mind that a neck mass is maybe part of a systemic illness, especially in the absence of an obvious etiology within the head and neck.1

1.3 Relevant Anatomy and Nodal Classification

Although detailed surgical anatomy and patterns of nodal spread are given elsewhere in this book, it is crucial to review anatomy of the neck for proper documentation of the findings and differential diagnosis. Localization of cervical lymphaden- opathy is closely associated with the origin of the pathology, and allows for a focused clinical examination with efficient use of diagnostic tools. It is also very important to organize physical examination findings in an order and understanding of the neck’s triangles and nodal levels. Therefore, relevant anatomy and nodal classification will be touched upon for these purposes.

1.3.1 Triangles of the Neck

Most physicians find it helpful to define the neck in terms of triangles when communicating the location of physical find- ings.5 Each side of the neck is bordered by the inferior edge of the mandible superiorly, trapezius muscle posteriorly, clavicle inferiorly, and midline medially. The sternocleidomastoid muscle (SCM) divides the neck into a posterior and an anterior triangle. The posterior triangle is then subdivided by the inferior belly of omohyoid muscle into the supraclavicular triangle inferiorly and the occipital triangle superiorly. The anterior triangle is further divided into four smaller triangles, which are submandibular, submental, muscular, and carotid triangles. The submandibular triangle is formed by the two bellies of digastric muscle and the inferior border of the mandible. The submental triangle lies between the anterior bellies of digastric muscles and the hyoid bone. The muscular triangle is bordered by the SCM, superior belly of the omohyoid muscle, and the midline. The carotid triangle is the area between the anterior border of SCM, superior belly of the omohyoid, and posterior belly of the digastric muscles.

1.3.2 Lymph Node Regions

Lymph nodes tend to be organized into groups or chains that drain discrete anatomic regions.6 Several classifications have been proposed to organize cervical lymph nodes into nodal regions that enable reliable localization of pathologic lymph nodes, effective communication among clinicians, and accurate cancer staging. The most widely used schemes historically have been those, such as that of Rouviere, describing nodal groups based on proximity to adjacent structures.7 This system was based on palpation and inspection of lymph nodes. With the development of cross-sectional imaging systems, a “level’’-based classification was proposed8 and adopted by the American Joint Committee on Cancer for both radiologists and clinicians involved in the care of head and neck cancer patients in order to reliably communicate the location of pathologic lymph nodes and for cancer staging.6 Nodal basins of the neck will be discussed in detail in another chapter of this book.

1.4 Diagnostic Testing

After acquiring a detailed history and necessary evidence from physical examination, it may be necessary to run additional diagnostic testing and/or imaging for accurate diagnosis. It is usually unnecessary and inefficient to run all imaging and diagnostic tests in every patient; the practitioner should have the knowledge on the indications, advantages, and pitfalls of each modality.

1.5 Laboratory Testing

Laboratory testing can usually be an adjunct to other findings in the differential diagnosis. Complete blood cell count can be useful to identify markers of infection, as elevated white blood cell count with neutrophil predominance. Elevated erythrocyte sedimentation rate and C-reactive protein (CRP) levels not only are useful in supporting the clinical suspicion of an infectious or an inflammatory mass, but also are used to monitor the response to treatment. Serologic testing can be necessary in the diagnosis or differential diagnosis of certain infectious diseases, such as tuberculosis, infectious mononucleosis, and brucellosis.

1.5.1 Imaging

Evaluation of a neck mass usually involves an imaging modality that confirms the presumed diagnosis or provides a differential diagnosis. The preferred imaging modality in the workup of a neck mass may differ mainly based on physical examination findings and associated conditions that may exclude utilization of certain modalities such as kidney failure that may exclude administration of iodine contrast in computed tomography (CT) or an implanted pacemaker that eliminates the option of performing a magnetic resonance imaging (MRI). Details ofana- tomic imaging and imaging criteria for characterization of metastatic lymph nodes are given elsewhere in this book. However, brief description of advantages and disadvantages of frequently used imaging modalities in differential diagnosis of neck masses are provided in this chapter (Table 1.1).

Table 1.1 Brief description of frequently used imaging modalities in differential diagnosis of cervical masses


Basic indication




First-line imaging in the evaluation of thyroid nodules and pediatric neck masses. Useful in salivary gland imaging

Inexpensive and quick. No ionizing radiation. Can be utilized without sedation. Can readily distinguish between a solid and a fluid-filled mass. Can be used in conjunction with fine-needle aspiration biopsy

Operator dependent. Limited use in imaging of deep structures and parapharyngeal space due to acoustic shadowing. Cannot provide anatomic details as a cross-sectional imaging modality

Computed tomography

Most frequently utilized imaging in adult neck masses. Iodinated contrast enhancement is usually necessary for better delineation of anatomic characteristics of bone, airway, soft tissues, and vasculature of the neck

Provides three-dimensional relationships of lymph nodes with other structures. Best for discretion of bone invasion or evaluation of bony lesions

May pose significant risk of radiation exposure, especially in pediatric population or in repeated utilization. Iodine contrast may cause allergic reaction or nephrotoxicity

Magnetic resonance imaging

Important part of treatment planning in salivary gland and oral cavity neoplasms

Provides best soft-tissue delineation. Good for depicting soft-tissue invasion and vascular invasion. Only imaging modality to show perineural invasion.

No ionizing radiation

Expensive and time-consuming. May require sedation or anesthesia in pediatric population. May not be tolerated by claustrophobics

Positron emission tomography

Useful for staging and follow-up of malignant diseases. Can be used in the search of unknown primary in neck metastases

Provides whole-body scanning

Narrow indication. Cost


Evaluation and preoperative assessment of vascular lesions or malignant lesions invading vascular structures

Digital subtraction angiography may be used for embolization of feeding vessels in paragangliomas

Narrow indication

Ultrasound (US) is typically the initial imaging performed for evaluation of a palpable neck mass as it utilizes no radiation, requires no sedation or intravenous contrast, is easily accessible, and is relatively low in cost. Advances in technology allowed clinicians to access more compact US devices with higher resolution at lower cost and helped popularizing clinician performed US examinations at office. US can provide information about the size and location of the lesion as well as its cystic or solid nature. Doppler feature can be utilized to identify vascularity of the mass.9 Certain findings in the US examination may provide clues in differentiating a normal or reactive lymph node from a malignant one, and also guide the examiner in performing needle biopsies for cytological evaluation. Normal lymph nodes are typically ovoid to kidney shaped in shape and are slightly hypoechoic when compared to the surrounding soft tissues with a hyperechoic region that represents the fatty hi- lum of the lymph node. On color Doppler examination, there is flow in normal lymph nodes, which is relatively increased near the hilum.9 Reactive lymph nodes are typically less than 1 to 1.5 cm in greatest diameter, and usually keep the fusiform shape with a short-to-long axis ratio of less than 0.5. Malignant lymph nodes are usually rounded in shape and increased in size, and have lost their characteristic architecture with lack of an echogenic fatty hilum, and distortion or displacement of normal vascularization.10

Despite being an excellent screening tool, US examination has several limitations and flaws in evaluation of neck masses. Penetration of high-frequency linear probe may be reduced at deep neck structures, especially at short and/or thick necks. Also, acoustic shadowing hinders evaluation of retrosternal, retropharyngeal lymph nodes, and parapharyngeal lesions. Proper US evaluation is also highly dependent on the skills and the proficiency of the examiner, especially in the pediatric age group.

For the adult population, the diagnostic algorithm usually continues with a cross-sectional imaging modality such as CT and/or MRI. CT continues to be the most frequently utilized modality. Discrimination of fine anatomic characteristics of bone and of the soft tissues of the neck is particularly facilitated by the use of iodinated contrast studies (Fig. 1.1). On the one hand, CT scans may provide excellent details about the head and neck mucosal sites, locate masses within or outside of glands or nodal chains, and give relation of the mass to lymph nodes, major blood vessels, airway, and bony structures such as the mandible and vertebral column.1 On the other hand, CT scans may expose the individual to radiation, which can be an important issue in pediatric cases or with repeated scans. Also, iodine contrast may cause allergic/anaphylactic reaction in susceptible individuals and may cause nephrotoxicity, particularly if utilized in a dehydrated patient.

MRI provides better soft-tissue delineation, with better appreciation of vascular and/or perineural invasion. MRI carries no risk of radiation; it can be safely used in pregnant or pediatric patients. On the other hand, MRI is less readily available and more expensive than the aforementioned studies.

CT and MRI are not substitutes for each other, but are complementary to each other in the evaluation of malignant neck masses. Physician chooses one or both, depending on the suspected pathology. CT and MRI are usually ordered together in the evaluation of masses involving oral cavity, skull base, pharynx, and parapharyngeal space.

Fig.1.1 Discretization of cervical lymphadenopathies can be difficult in short and thick necks (a). Computed tomography with iodine contrast provides detailed information of lymph nodes regarding their size, location, and relationship to other structures (b).

Positron emission tomography (PET) is another important imaging modality in evaluation of cervical lymphadenopathy, especially in the presence of a primary tumor in the head and neck. PET provides important information in head and neck oncology, especially in initial staging and in evaluation of the treatment response.

1.5.2 Fine-Needle Aspiration Biopsy and Cytological Analysis

Fine-needle aspiration biopsy (FNAB) has become an essential tool in the diagnosis of neck masses. Imaging can be highly suggestive in the diagnosis of certain neck masses with vascular, infectious, or congenital origin (i.e., thyroglossal duct cyst [TDC] or branchial cleft cyst), but cytopathological evaluation is usually necessary for most neck masses in adult patients. The procedure is quick and safe. Generally, a 22- to 25-gauge needle with 10-mL syringe is inserted into the mass, and multiple passes through the lesion are made with or without the suction of the syringe plunger. The aspirate is transferred on a microscope slide and dried on air, or inserted to a liquid medium and transferred to the laboratory depending on the practice of the institution. This can also allow staining of the tissue block obtained during the aspiration process. FNAB cytology is highly sensitive and specific in differentiating cystic masses from solid, benign masses from malignant, and epithelial metastases from lymphoid infiltration. Analysis of tissue architecture with immunohistochemistry and/ or flow cytometry is usually required for the diagnosis of lymphoma and other pathologies of lymphoid origin. Therefore, core needle biopsy or open biopsy may be warranted for further identification of such lesions. Occasionally, CT- or MRI-guided FNAB may be necessary where US guidance is not adequate for targeting masses in locations with difficult access such as retropharyngeal space or the pterygopalatine fossa.

1.6 Differential Diagnosis of Neck Masses

The differential diagnosis of the neck masses can be listed under three main categories:

• Infectious and inflammatory lesions.

 Congenital lesions.

 Neoplasms of the neck.

1.6.1 Infectious and Inflammatory Lesions

Infectious and inflammatory lesions are the most frequently encountered neck masses in both adults and children. The neck has an extensive capillary lymphatic network that drains skin, upper aerodigestive tract, salivary glands, and thyroid gland. Approximately 40% of all the lymph nodes in the body are located in the head and neck.6 Thus, it is quite common to encounter enlarged submandibular masses as reactive lym- phadenopathy in the neck, after a viral or bacterial upper respiratory tract infection or a dental infection. Often, these reactive nodes will manifest as palpable, mobile, and tender masses, and the patient may report fever, upper respiratory infection symptoms, tooth pain, or dysphagia.1 Occasionally, these lymph nodes will become necrotic in the course of a bacterial infection, and an abscess forms. US is usually the preferred imaging modality in such case, which will readily show the necrotic area in the lymph node, and enable aspiration of fluid for culture and cytology. CT scan with iodine contrast is best for delineating diffuse lymphadenopathy or an abscess formation in parapharyngeal, retropharyngeal, or masticatory spaces.

Granulomatous diseases include a wide variety of pathologies, which may occasionally present as a neck mass. These include infectious or autoimmune diseases such as sarcoidosis, tuberculosis, atypical mycobacterial infections, cat-scratch disease, or Kawasaki’s disease. US-guided FNAB cytology may reveal important features of the disease or exclude a malignant process. Exci- sional or incisional biopsies are a last resort because of the concern for creation of a chronically draining wound.1

Infection or inflammation of the salivary or thyroid glands is not uncommon. Obstruction of Wharton’s or Stensen’s ducts by sialolithiasis or mucus plugs causes tender and swollen glands with warmth and hyperemia. The symptoms are usually unilateral and confined to one gland, and are usually exacerbated with ingestion of food or drinks. Infection may ensue behind the obstruction, and thus, examiner can see purulent discharge from the orifice of the salivary duct upon massage to the respective salivary gland. US shows signs of inflamed parenchyma and often dilated duct with calculi in it. CT scan may better show the place of calculi deposits, and often ordered if surgical treatment is anticipated.

Inflammatory diseases of thyroid gland can be encountered in the differential diagnosis of anterior neck masses. Three broad categories of thyroiditis are defined: (1) acute suppurative thyroiditis, which is due to bacterial infection; (2) subacute thyroiditis, which results from a viral infection of the gland; and (3) chronic thyroiditis, which is usually autoimmune in nature. Acute thyroiditis is characterized with painful palpable thyroid gland with signs of infection. The pain worsens with extension of the neck. Subacute thyroiditis can also cause a tender and palpable thyroid gland, with systemic symptoms as fatigue, malaise, and low-grade fever. Chronic autoimmune thyroiditis has a slower course and results in a diffuse, nontender goiter. Diagnosis is usually done on clinical and laboratory findings. US is the preferred imaging modality for diagnosis and follow-up.

1.6.2 Congenital Lesions

Congenital lesions are an important cause of neck masses in childhood or early adulthood period. Detailed description of em-bryological development of the neck is beyond the scope of this chapter, but understanding certain features of congenital lesions is usually required for differential diagnosis and treatment.

Thyroglossal Duct Cyst

TDC is the most common congenital neck mass in children, which presents as a midline cystic mass. It represents 70% of all congenital neck masses.1 TDCs are formed due to a congenital defect in the closure of embryonic descent route of the thyroid gland. This route originates from foramen cecum, in the base of tongue, and courses in the anterior neck, close to the midline, usually deep to the hyoid bone and the strap muscles, to the isthmus of the thyroid gland. Remnants of the thyroglossal duct are actually found in approximately 7% of the population, but only a small number of these ever become symptomatic.11 TDCs usually become evident in childhood as a midline cystic neck mass that elevates in the neck with tongue protrusion or swallowing. Occasionally, cyst fluid gets infected, and presents as a painful and inflamed midline mass.

Evaluation of thyroid function and US imaging is necessary to rule out lingual ectopic thyroid tissue. Acute infection of TDC is treated with aspiration of cyst contents and antibiotics. Complete removal of descent route by the Sistrunk procedure is recommended for definitive treatment.

Branchial Cleft Anomalies

Branchial cleft anomalies are also common both in pediatric and in young adult populations. One-third of all congenital neck masses are the result of incompletely obliterated embryonic branchial tissue, which may be in the form of a cyst, sinus, or a fistula.1.11 Evaluation of their location and course requires understanding the branchial cleft embryonic development. First-arch anomalies represent about 1% of all branchial arch anomalies and are classified as type 1 or type 2. Type 1 anomalies are duplications of the external auditory canal, and they can have attachments to the skin of the external auditory canal. Type 2 anomalies are found within the parotid gland deep to the facial nerve. Their relation with the facial nerve makes the management difficult.1

Anomalies of the second arch are by far the most common (representing 95% of all branchial cleft anomalies) and typically manifest as a submandibular cystic mass, anterior to the SCM (Fig. 1.2). The course runs always lateral to the internal carotid artery. If it is in the form of sinus or fistula, it enters the pharynx at the tonsillar fossa. It may get infected during the course of an upper respiratory tract infection. Differential diagnosis may be required from cystic metastatic lymph nodes, especially in the young adults.

Third- and fourth-arch anomalies are extremely rare. Third- arch anomalies run deep to the internal carotid artery and open into the piriform sinus through the thyrohyoid membrane. They are superior to the superior laryngeal nerve. Fourth-arch anomalies are side dependent: on the right, they lie deep to the subclavian artery, whereas on the left they course under the aortic arch. Ultimately, they can enter the piriform sinus, inferior to the superior laryngeal nerve, and can be intimately associated with the thyroid gland.1

Evaluation of branchial cleft anomalies usually requires CT scan and US. US shows the cyst structure and enables aspiration and drainage, if required. CT scan with contrast shows the anatomic relations in the neck including the carotid artery.

Fig. 1.2 (a) Second branchial arch cyst represents as a mass in lateral neck compartment (thick arrow). (b) Contrast-enhanced computed tomography shows the location of the cyst and its relation to internal carotid artery. Arrow indicates the cyst structure displacing the carotid sheath and its components, posteriorly.

Teratoma and Dermoid Cysts

Teratomas are developed from embryonic remnants of all three germ layers. Head and neck teratomas comprise approximately 2% of all teratomas.12 They start to form in utero, during the second trimester, and present at birth as firm, midline neck masses. Occasionally, they can be diagnosed prenatally as cystic soft-tissue masses containing calcifications on imaging. The presence of calcifications within a neck mass is strongly suggestive of a teratoma. In neonates, a teratoma can present as a rapidly expanding neck mass that may compromise airway or deglutition. Surgical excision is the treatment of choice.

Dermoid cysts are the result of trapped rests of epithelial elements along natural lines of embryonic fusion, and are usually found in the midline or just lateral of midline. These cysts contain both ectodermal and endodermal elements. They are lined by epithelium but contain endodermal elements as hair follicles and sebaceous glands, which grow slowly due to accumulation of the sebaceous content. Infection of the cyst content is rare. They are usually diagnosed prior to 3 years of age.12

Hemangiomas and Lymphangiomas

Hemangiomas are bluish-purple colored, soft, compressible lesions, commonly presented within the first few months of life. These lesions are caused by the proliferation of vascular endothelial cells, and commonly encountered in the head and neck. Clinically, they show three phases of growth: a rapid, proliferative phase is followed by a stable phase, and then involution. Complete involution can be seen in half of patients before the age of 5, and nearly all tumors regress by ages 10 to 12.11

Vascular malformations are classified according to dominant type of vascular flow. Arteriovenous fistula and arteriovenous malformation are high-flow lesions with aberrant arterial and venous connections that lack parenchyma. Besides causing a mass with poor cosmetic appearance, they may result in ischemic ulcers or even congestive heart failure.11 Doppler US and MRI angiography are excellent modalities for visualization of these lesions. Low-flow vascular malformations encompass venous malformations and lymphatic malformations. Venous malformations are made from dysplastic venous channels that present as blue or purple masses that feel spongy to palpation. Often, they will enlarge with Valsalva’s maneuvers, and they are easily differentiated from lymphatic malformations with MRI angiography.

Lymphangiomas are also soft, compressible masses of benign hamartomatous lymphatic vessels and channels. They are commonly seen at birth or before age 2 years, and located most commonly in the posterior triangle of the neck.11 They can often enlarge within the course of upper respiratory infections, but do not increase in size with Valsalva’s maneuvers. Bleeding can be seen into the cystic spaces, which may result in dense phleboliths. Diagnosis is usually done with history and clinical examination findings. Evaluation is usually done by MRI and US.

1.6.3 Neoplasms of the Neck


Paraganglia are collections of cells of neuroectodermal origin that secrete catecholamines. They have an important functional role during embryogenesis, when they serve as the major source of catecholamines. After birth, most paraganglia nests disappear, with the exception of the adrenal medulla and the sites around the autonomic nervous system. In the adult, the function of the paraganglia is to help the autonomic nervous system respond to stressors such as hypercapnia, hypoxia, or decreased pH.11

Paragangliomas are highly vascular, slow-growing, mostly benign lesions originating from the nests of paraganglia, with less than 10% thought to be malignant. In the head and neck, they occur in three main locations and their presentations differ accordingly: carotid body, jugulotympanic region, and vagus nerve paragangliomas. Carotid body tumors are located in bifurcation of the carotid, and typically present as a painless, slowly enlarging neck mass (Fig. 1.3). The classic diagnostic features are a nontender mass at the carotid triangle that is mobile horizontally, but fixed vertically, which has an associated bruit or vascular thrill. As these lesions enlarge, they may also cause cranial nerve or sympathetic chain neuropathies. Vagal paragangliomas will have a similar presentation but may have an increased incidence of hoarseness, pharyngeal fullness, or dysphagia at presentation. Proper evaluation and differential diagnosis is done with angiography, CT angiography, and MRI angiography. These lesions should be diagnosed by physical examination and imaging, and FNAB should be avoided.11

Fig.1.3 (a) Carotid body tumor is a slow-growing, pulsatile mass in the lateral neck, located within the carotid triangle (thick arrow). (b) Magnetic resonance imaging with angiography shows typical location at the carotid bifurcation. (c) Arrows indicate the characteristic displacement of carotid arteries due to tumor structure (Lyre’s sign).

Neurogenic Neoplasms

Neurogenic neoplasms of the neck can be schwannomas, neurofibromas, malignant peripheral nerve sheath tumors, or tumors of neuroblastic origin such as neuroblastoma or ganglioneuroblastoma. Schwannomas are the benign tumors of Schwann cell origin, and are the most common solitary neurogenic tumors of the neck. These lesions occur in patients who are 20 to 50 years old, and 25 to 45% of extracranial schwannomas occur in the neck.11 Schwannomas can originate from the cranial nerves, sympathetic chain, or spinal nerve roots, and therefore can commonly be encountered as a parapharyngeal masses. Clinical course can be asymptomatic, until compressive symptoms occur. Radiological differential diagnosis from other parapharyngeal masses can be best done with MRI, since cervical schwannomas—like paragangliomas of the neck—typically develop in the poststyloid parapharyngeal space, displacing carotid sheath contents anteriorly.

Neuromas typically result from traumatized nerve endings of sensory nerves. They are commonly encountered after neck dissection or parotidectomy, from the scarified nerve endings of greater auricular nerve or cervical plexus. Patients usually present with a painful neck mass, radiating to shoulder or temporal area.


Lipomas represent the most common subcutaneous soft-tissue tumor of adults.11 They are slow-growing, benign tumors composed of adipocytes, which commonly occur in the posterior triangle but can occur throughout the neck and face. Lipomas are most often asymptomatic. When they arise from subcutaneous fat, palpation yields a sliding, lobulated mass with normal skin on it, which helps differentiate it from a sebaceous cyst or abscess. Deep lipomas have a firm to rubbery consistency on palpation. Differentiation of deep lipomas from low-grade liposarcomas is difficult; therefore, serial imaging with MRI or CT or complete surgical excision of enlarged lipomas is recommended.

Neoplasms of Salivary Glands

Salivary gland tumors represent a small percentage (about 1%) of all head and neck masses, but are the source of diverse group of pathologies, and, thus, are important to review. Besides major salivary glands (parotid, submandibular, and sublingual), there are numerous minor salivary glands found throughout the upper aerodigestive tract. However, the majority of salivary gland neoplasms occur in parotid gland, and among those, the majority are benign neoplasms. In adults, 80% of parotid lesions are benign; the majority of these are pleomorphic adenomas.

Only 15 to 20% of salivary gland tumors arise in submandibular and sublingual glands, but up to 50 to 75% of those are malignant. Although it is also uncommon to diagnose a salivary gland tumor in pediatric age group, a greater percentage of those are malignant. Hemangiomas represent the most common benign lesions of the parotid glands in children. Mucoepidermoid carcinomas are the most common salivary gland malignancies in all groups.111 Parotid or minor salivary gland tumors may also present as parapharyngeal space masses and are typically located at the prestyloid compartment displacing the carotid artery posteriorly.

US imaging and US-guided FNAB cytology are the preferred diagnostic utilities in salivary gland tumors. CT or MRI may be useful in surgical planning and showing invasion into surrounding structures and/or lymph node metastasis, in the treatment of malignant salivary gland tumors.

Thyroid Neoplasms

Neoplasms of the thyroid gland are an important cause of neck mass among all age groups. The thyroid gland may host pathologies differing from a benign goiter to a thyroid carcinoma. Thyroid carcinoma is also an important cause of metastatic lymphadenop-athy in the neck. US-guided FNAB is the gold standard diagnostic modality in the evaluation of a thyroid nodule.

Malignancy Harboring Lymph Nodes in the Neck

Malignancy harboring lymph nodes in the neck can represent as primary lymph node malignancies such as various types of lymphoma, regional metastatic disease from a primary source in the head and neck, or distant metastatic disease from a primary outside of the head and neck region.


Both types of lymphoma (Hodgkin’s and non-Hodgkin’s) present commonly as a neck mass; therefore, the otolaryngologist is often the first physician to evaluate a patient with lymphoma. Lymphoma represents the most common type of head and neck malignancy in the pediatric population and is the second most common type in adults.11 Being a highly curable ma- lignancy—if treated properly—differentiation of a benign, reactive lymphadenopathy from a lymphoma is an important task, especially in the pediatric age group.

Eighty percent of patients with Hodgkin’s disease (HD) have cervical nodal disease, whereas only about 33% of those with non-Hodgkin lymphoma (NHL) have involved cervical lymph nodes. NHL, however, is approximately five times more common than HD in the head and neck.11 The majority of lymph nodes associated with lymphoma presents as a nontender mass of greater than 2 weeks’ duration, usually at supraclavicular area or posterior neck triangle. HD is primarily a disease confined to lymph nodes, but NHL may present at extra nodal sites as Waldeyer’s ring, salivary glands, or thyroid, in 25 to 40% of patients at initial diagnosis.13

Diagnosis of lymphoma involves combination of history, physical examination, imaging, and biopsy. Lymphoma usually shows systemic involvement with multiple lymph nodes in other areas (axilla, mediastinum, abdomen, or groin) and/or hepatosplenomegaly. Thus, systemic involvement should be questioned and examined. Systemic symptoms (also known as B symptoms) include fever greater than 38 °C, night sweats, and unintentional weight loss; these may also exist during presentation of the patient. Indirect mirror or flexible endoscopic examination should be employed to rule out Waldeyer’s ring involvement in NHL. A complete blood count with differential and peripheral smear is usually warranted. Bone marrow aspiration biopsy is usually performed by oncologists. Serum lactate dehydrogenase level may be found elevated in both types of lymphomas, and is an important prognostic factor for indicating treatment response.14

US is usually the preferred first-line imaging modality in evaluation of lymph nodes in pediatric age group. US shows rounded lymph nodes in HD and enlarged lymph node masses, often conglomerated lymph nodes with ill-defined borders in NHL. Contrast-enhanced CT is the gold standard in evaluation of lymphoma. US-guided FNAB or core needle biopsy may be ordered before an open biopsy, which may direct clinicians to a neoplasm of lymphoid lineage. However, an incisional or excisional open biopsy is often required for definitive histopathological diagnosis and classification. Whole-body scan with 18-fluorodeoxyglucose (18-FDG) PET-CT or cranial-neck-thorax-abdomen-pelvic CT with contrast is ordered for staging of the disease.

Regional and Distant Metastasis of the Neck, Carcinoma of Unknown Primary

Regional metastasis to the neck is a common finding in squamous cell carcinoma (SCC) of the upper aerodigestive tract in smokers and elderly males. However, its incidence is increasing in the younger, nonsmoker population, mostly due to HPV infection. Additionally, malignant thyroid and salivary gland adenocarcinomas are also commonly encountered with metastatic lymph nodes in the neck. Distant metastasis as a neck mass is a relatively rare condition, although hundreds of neoplasms have been described that can metastasize to the neck. The most common distant sites include the lung, esophagus, kidney, ovary, cervix, and prostate.15 Each condition is managed in accordance with the oncologic principles for treating the given malignancy. However, metastasis in the lymphatic structures of the neck without a given primary site is a challenge for the clinician in the management.

Principles of management of metastatic lymph nodes with unknown primary involves the same steps with any other mass in the neck; biopsy follows history, physical examination, and imaging. This examination should consist of careful inspection and palpation of all mucosal subsites of the oral cavity and oropharynx, as well as fiberoptic flexible and/or rigid endoscopy. During endoscopy, particular attention should be paid to the common sites of occult primary origin such as nasopharynx, palatine tonsils, tongue base, supraglottic larynx, hypopharynx, and the floor of the mouth (Fig. 1.4).

Contrast-enhanced CT from cranium to abdomen and US of the neck are the first-line imaging modalities both for defining the characteristics of metastatic mass and for revealing the site of primary. Gadolinium-enhanced MRI may be preferred for better definition of soft tissues. 18-FDG PET-CT is popularized in determining the site of origin and directing biopsies.

Diagnosis of a metastatic carcinoma in the neck is typically performed by cytopathological evaluation of an FNAB specimen obtained with or without US or CT guidance. Occasionally, the diagnosis is obtained by performing an incisional or excisional biopsy. Cytopathological or histopathological findings in the metastatic node may assist in determining the primary site. A diagnosis of adenocarcinoma usually reveals its primary in lung, bronchi, stomach, prostate, or intestines. Metastasis from a thyroid carcinoma is usually a straightforward diagnosis with typical US, cytological, and immunohis- tochemistry findings. SCC is the most common type of histology among the metastasis with unknown primary. Upper aerodigestive tract sites should be examined thoroughly, with special emphasis on the common sites of occult origin, especially with fiberoptic endoscopy. Molecular and/or genetic demonstration of HPV or EBV genomes in metastatic lymph node aspirates provide important clues in the subsite of origin of the primary.

The location of the metastatic lymph node also offers important diagnostic information on the location of the primary site. Regional metastases from primary lesions of the oral cavity are typically found in levels I, II, and III, while primary malignancies of oropharynx, hypopharynx, and larynx are found at levels II, III, and IV. Nasopharyngeal cancer typically metastasizes to level V.15 When the mass presents in the supraclavicular region, esophageal and pulmonary primary sites should be considered in addition to abdominal and pelvic locations.15

Fig. 1.4 Detailed head and neck examination in the evaluation of bilaterally enlarged cervical lymph nodes (a) may provide vital information regarding the source of the problem. An otoscopic examination revealing otitis media with effusion (b) may lead the clinician directly to perform a directed fiberoptic examination of the nasopharynx revealing a lesion (thick arrow) (c).

If no primary site can be revealed with physical examination and imaging, a diagnostic panendoscopy and biopsy is required under general anesthesia. The physician examines the whole upper aerodigestive tract, under the illumination and magnification of endoscope and/or operating microscope, and palpates carefully the floor of mouth and oropharyngeal subsites including the tongue base, palatine tonsils, and glossotonsillar sulcus. Any mucosal or submucosal lesions should be biopsied, as well as blind biopsies from common occult primary sites such as Rosenmüller fossae of nasopharynx, ipsilateral palatine tonsil, tongue base, piriform sinus, and postcricoid region. The ipsilat- eral tonsil has been reported to harbor the occult primary in 20 to 40% of cases. The next most common subsite is the tongue base. PET-CT maybe helpful in the diagnosis of an occult primary malignancy in the head and neck; however, the clinician should keep in mind that this modality should be employed before performing any biopsies, since biopsy-related inflammatory response may cause false-positives.

1.7 Conclusion

Neck masses are common in the general population and represent a wide array of pathologies including enlarged lymph nodes. Both benign and malignant lesions can present as a mass in the neck, which makes a careful approach to these lesions important. The likelihood of malignancy increases in an elderly, male patient who consumes alcohol and tobacco products. On the other hand, inflammatory neck masses are the most common neck masses in pediatric and young adult age groups. A thorough head and neck examination (with flexible endoscopy, where indicated) is the crucial step for diagnosis. Neck imaging in the form of US, CT, MRI, or PET-CT is usually employed as additional diagnostic tools depending on differential diagnoses. FNAB is the key step toward tissue diagnosis. There is a wide variety of neck masses that may mimic an enlarged lymph node, and every clinician should be knowledgeable in the process of differential diagnosis for a mass in the neck.


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